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  1. Plants-based natural compounds are well-identified and recognized chemoprotective agents that can be used for primary and secondary cancer prevention, as they have proven efficacy and fewer side effects. In to...

    Authors: Praveen Dhyani, Priyanka Sati, Eshita Sharma, Dharam Chand Attri, Amit Bahukhandi, Bekzat Tynybekov, Agnieszka Szopa, Javad Sharifi-Rad, Daniela Calina, Hafiz A. R. Suleria and William C. Cho
    Citation: Cancer Cell International 2022 22:305
  2. Mitophagy is a type of selective autophagy for dysfunctional mitochondria and plays a key role in tumorigenesis and cancer progression. However, whether mitophagy plays a role in colon cancer remains unclear. ...

    Authors: Tao Jiang, Lulu Peng, Qian Wang, Bingyu Huang, Dewei Peng, Lintong Men, Yue Jiang, Mengying Zhu, Moran Wang, Li Lin, Jiagao Lv and Sheng Li
    Citation: Cancer Cell International 2022 22:304
  3. Long non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various processes in humans. Recently, there is more and more interest i...

    Authors: Xuyu Chen, Qian Luo, Yanan Xiao, Jing Zhu, Yirao Zhang, Jie Ding and Juan Li
    Citation: Cancer Cell International 2022 22:303
  4. Single-nucleotide polymorphisms (SNPs) in N6-methyladenosine (m6A) related genetic locus play significant roles in tumorigenesis and development. The expression level of many oncogenes and tumour suppressor ge...

    Authors: Jiancheng Lv, Qiang Song, Kexin Bai, Jie Han, Hao Yu, Kai Li, Juntao Zhuang, Xiao Yang, Haiwei Yang and Qiang Lu
    Citation: Cancer Cell International 2022 22:301
  5. The incidence of non-virus-related hepatocellular carcinoma (NV-HCC) in hepatocellular carcinoma (HCC) is steadily increasing. The aim of this study was to establish a prognostic model to evaluate the overall ...

    Authors: Yu Jiang, Shulin Chen, Yaxian Wu, Yuanye Qu, Lina Jia, Qingxia Xu, Shuqin Dai and Ning Xue
    Citation: Cancer Cell International 2022 22:300
  6. Clear cell renal carcinoma is commonly known for its metastasis propensity to outspread to other organs and is asymptomatic in the early stage. Recent studies have shown that deficiencies in CYP11A1 expression...

    Authors: Hien Thi My Ong, Tae-Hun Kim, Eda Ates, Jae-Chul Pyun and Min-Jung Kang
    Citation: Cancer Cell International 2022 22:299
  7. Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural phenol that is present in the skin of the grape, blueberry, raspberry, mulberry, and peanut. This substance is synthesized in these plants following inj...

    Authors: Soudeh Ghafouri-Fard, Zahra Bahroudi, Hamed Shoorei, Bashdar Mahmud Hussen, Seyedeh Fahimeh Talebi, Sadia Ghousia Baig, Mohammad Taheri and Seyed Abdulmajid Ayatollahi
    Citation: Cancer Cell International 2022 22:298
  8. Mucosal-associated invariant T (MAIT) cells are innate-like T cells, some studies have reported that the number of circulating MAIT cells reduced in patients with acute graft-versus-host-disease (aGVHD) develo...

    Authors: Zhao Wang, Sudong Zhang, Xiaoyu Zhang, Li Liu, Lukun Zhou, Yuyan Shen, Rongli Zhang, Yi He, Donglin Yang, Erlie Jiang, Xiaoming Feng, Jiaxi Zhou, Tao Cheng, Mingzhe Han and Sizhou Feng
    Citation: Cancer Cell International 2022 22:297
  9. Thyroid carcinoma (THCA) is the most common endocrine-related malignant tumor. Despite the good prognosis, some THCA patients may deteriorate into more aggressive diseases, leading to poor survival. This may b...

    Authors: Yuan Qin, Dai Zhang, Huan Zhang, Lan Hou, Zhe Wang, Liu Yang, Mingkun Zhang, Ge Zhao, Qing Yao, Rui Ling and Juliang Zhang
    Citation: Cancer Cell International 2022 22:296
  10. N6-methyladenosine (m6A) is an abundant nucleotide modification in mRNA, but there were few studies on its role in cancer drug sensitivity and resistance. Anlotinib has been proved to have effective antitumor eff...

    Authors: Jie Chen, Shuai Li, Zhexun Huang, Congyuan Cao, Anxun Wang and Qianting He
    Citation: Cancer Cell International 2022 22:295
  11. Thymosin family genes (TMSs), biologically important peptides with diverse intracellular and extracellular functions, have been shown to promote the progression of multiple cancers. However, multiomics charact...

    Authors: Ye Xiong, Yanhua Qi, Ziwen Pan, Shaobo Wang, Boyan Li, Bowen Feng, Hao Xue, Rongrong Zhao and Gang Li
    Citation: Cancer Cell International 2022 22:294
  12. Ultrasound-targeted microbubble destruction (UTMD) technology is a new drug and gene delivery strategy. This study investigates novel ultrasound (US) sensitive siRNA-loaded nanobubbles (siRNA-NBs) to explore t...

    Authors: Yao Zhang, Wenhao Lv, Hui Li, Tiantian Dong, Hao Wu, Chunhong Su, Hong Shu and Fang Nie
    Citation: Cancer Cell International 2022 22:293
  13. Lung adenocarcinoma (LUAD) is a leading cause of cancer-related death worldwide. Ferroptosis, a form of cell death characterized by iron-dependent lipid peroxidation. However, the involvement of ferroptosis in...

    Authors: Biao Deng, Jing Xiang, Zhu Liang and Lianxiang Luo
    Citation: Cancer Cell International 2022 22:292
  14. Perinatal blood including umbilical cord blood and placental blood are splendid sources for allogeneic NK cell generation with high cytotoxicity of combating pathogenic microorganism and malignant tumor. Despi...

    Authors: Haibo Gao, Min Liu, Yawei Zhang, Leisheng Zhang and Baoguo Xie
    Citation: Cancer Cell International 2022 22:291
  15. 5-fluorouracil (5-FU)-based chemotherapy regimen has been widely used for the treatment of gastric cancer, but meanwhile the development of chemotherapeutic resistance remains a major clinical challenge. Tumor...

    Authors: Pengfei Su, Lin Jiang, Yingjing Zhang, Tian Yu, Weiming Kang, Yuqin Liu and Jianchun Yu
    Citation: Cancer Cell International 2022 22:290
  16. The emergence of de novo or intrinsic trastuzumab resistance is exceedingly high in breast cancer that is HER2 positive and correlates with an abundant cancer stem cell (CSC)-like population. We sought to exam...

    Authors: Soeun Park, Jung Min Park, Minsu Park, Dongmi Ko, Seongjae Kim, Juyeon Seo, Kee Dal Nam, Eunsun Jung, Lee Farrand, Yoon-Jae Kim, Ji Young Kim and Jae Hong Seo
    Citation: Cancer Cell International 2022 22:289
  17. Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor for the Wnt5a ligand that was shown to play a dual role in cancer. ROR2 was shown to either suppress or promote tumor progression in differe...

    Authors: Pablo Lopez-Bergami
    Citation: Cancer Cell International 2022 22:288
  18. KRAS-driven metabolic reprogramming is a known peculiarity features of pancreatic ductal adenocarcinoma (PDAC) cells. However, the metabolic roles of other oncogenic genes, such as YY1, in PDAC development are st...

    Authors: Bin Li, Junyi Wang, Jing Liao, Minghui Wu, Xiangshu Yuan, Hezhi Fang, Lijun Shen and Minghua Jiang
    Citation: Cancer Cell International 2022 22:287
  19. Intratumoral (IT) delivery of toll-like receptor (TLR) agonists has shown encouraging anti-tumor benefit in preclinical and early clinical studies. However, IT delivery of TLR agonists may lead to rapid effusi...

    Authors: Luis Alejandro Zúñiga, Torben Leßmann, Karan Uppal, Nicola Bisek, Enping Hong, Caroline E. Rasmussen, Jens-Jakob Karlsson, Joachim Zettler, Lars Holten-Andersen, Kathy Bang, Dhruv Thakar, Yu-Chi Lee, Salomon Martinez, Simran Singh Sabharwal, Sebastian Stark, Frank Faltinger…
    Citation: Cancer Cell International 2022 22:286
  20. Maternally expressed 8 (MEG8) is a long non-coding RNA which is expressed in the nucleus. It is highly expressed in adrenal, placenta and brain. Recent studies have shown contribution of MEG8 in different diso...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Seyedpouzhia Shojaei
    Citation: Cancer Cell International 2022 22:285
  21. The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autoph...

    Authors: Eunus S. Ali, Kangkana Mitra, Shamima Akter, Sarker Ramproshad, Banani Mondal, Ishaq N. Khan, Muhammad Torequl Islam, Javad Sharifi-Rad, Daniela Calina and William C. Cho
    Citation: Cancer Cell International 2022 22:284
  22. Clear cell renal cell carcinoma (ccRCC) is characterized by the accumulation of lipid-reactive oxygen species. Ferroptosis, due to the lipid peroxidation, has been reported to be strongly correlated with tumor...

    Authors: Zhenpeng Zhu, Cuijian Zhang, Jinqin Qian, Ninghan Feng, Weijie Zhu, Yang Wang, Yanqing Gong, Xuesong Li, Jian Lin and Liqun Zhou
    Citation: Cancer Cell International 2022 22:283
  23. Sonic Hedgehog (Shh) signaling cascade is one of the complex signaling pathways that control the accurately organized developmental processes in multicellular organisms. This pathway has fundamental roles in t...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Majid Samsami
    Citation: Cancer Cell International 2022 22:282
  24. MicroRNAs (miRNAs) are small-sized transcripts with about 22 nucleotide length. They have been shown to influence almost every aspect of cellular functions through regulation of expression of target genes. miR...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Majid Samsami
    Citation: Cancer Cell International 2022 22:281
  25. Long non-coding RNA (LncRNA) is a novel and diverse class of regulatory transcripts that are frequently dysregulated in numerous tumor types. LncRNAs are involved in a complicated molecular network, regulating...

    Authors: Muhammad Irfan, Zeeshan Javed, Khushbukhat Khan, Naila Khan, Anca Oana Docea, Daniela Calina, Javad Sharifi-Rad and William C. Cho
    Citation: Cancer Cell International 2022 22:280
  26. Cancer is a major health concern and accounts for one of the main causes of death worldwide. Innovative strategies are needed to aid in the diagnosis and treatment of different types of cancers. Recently, ther...

    Authors: Nouf S. Al-Numair, Abdulrahman Theyab, Faisal Alzahrani, Anwar M. Shams, Ibrahim O. Al-Anazi, Atif Abdulwahab A. Oyouni, Osama M. Al-Amer, Charalampos Mavromatis, Islam M. Saadeldin, Wed A. Abdali and Yousef M. Hawsawi
    Citation: Cancer Cell International 2022 22:279
  27. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has an extremely poor prognosis. We aimed to determine the latent relationships between TRIM36 regulation of apoptosis and the...

    Authors: Qing Tong, Mingyu Yi, Panpan Kong, Lin Xu, Wukui Huang, Yue Niu, Xiaojing Gan, Huan Zhan, Rui Tian and Dong Yan
    Citation: Cancer Cell International 2022 22:278
  28. Circular RNAs (circRNAs) represent a class of newly identified transcripts that act as competing endogenous RNAs (ceRNAs) to modulate gene expression by competing for the shared microRNAs (miRNAs) in humans. I...

    Authors: Qian Fei, Yuhe Lin, Mi Zhang, Jinshuai Guo and Yuan Liang
    Citation: Cancer Cell International 2022 22:277
  29. Molecular heterogeneity is one of the most important concerns in colorectal cancer (CRC), which results in a wide range of therapy responses and patient prognosis. We aimed to identify the genes with high hete...

    Authors: Ebrahim Salehitabar, Mohammad Mahdevar, Ali Valipour Motlagh, Farzad Seyed Forootan, Sara Feizbakhshan, Dina Zohrabi and Maryam Peymani
    Citation: Cancer Cell International 2022 22:276
  30. The p21-activated kinase (PAK) family (PAKs) plays a key role in the formation and development of human tumors. However, a systematic analysis of PAKs in human cancers is lacking and the potential role of PAKs...

    Authors: Kunjian Lei, Min Luo, Zewei Tu, Shigang Lv, Junzhe Liu, Chuandong Gong, Minhua Ye, Miaojing Wu, Yilei Sheng, Xiaoyan Long, Jingying Li, Xingen Zhu and Kai Huang
    Citation: Cancer Cell International 2022 22:275
  31. Recent advances in omics technology have prompted extraordinary attempts to define the molecular changes underlying the onset and progression of a variety of complex human diseases, including cancer. Since the...

    Authors: Nasrin Gholami, Amin Haghparast, Iraj Alipourfard and Majid Nazari
    Citation: Cancer Cell International 2022 22:274
  32. ING genes belong to family of tumor suppressor genes with regulatory functions on cell proliferation, apoptosis, and cellular senescence. These include a family of proteins with 5 members (ING1-5), which are down...

    Authors: Mohammad Taheri, Bashdar Mahmud Hussen, Sajad Najafi, Atefe Abak, Soudeh Ghafouri-Fard, Majid Samsami and Aria Baniahmad
    Citation: Cancer Cell International 2022 22:272
  33. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer and is susceptible to develop gemcitabine (GEM) resistance. Decreased expression of human equilibrative nucleoside transporter 1 (...

    Authors: Yue Xi, Ting Li, Yun Xi, Xinyi Zeng, Ying Miao, Rui Guo, Min Zhang and Biao Li
    Citation: Cancer Cell International 2022 22:271
  34. Long Intergenic Non-Protein Coding RNA 1133 (LINC01133) is a long non-coding RNA (lncRNA) which interacts with miR-106a-3p, miR-576-5p, miR-495-3p, miR-205, miR-199a-5p, miR-4784, miR-30a-5p, miR-199a, miR-30b...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Majid Mokhtari
    Citation: Cancer Cell International 2022 22:270
  35. A pharmacological class known as immune checkpoint inhibitors (ICIs) has been developed as a potential treatment option for various malignancies, including HCC. In HCC, ICIs have demonstrated clinically signif...

    Authors: Faezeh Sharafi, Sadegh Abaei Hasani, Samira Alesaeidi, Mohammad Saeed Kahrizi, Ali Adili, Shadi Ghoreishizadeh, Navid Shomali, Rozita Tamjidifar, Ramin Aslaminabad and Morteza Akbari
    Citation: Cancer Cell International 2022 22:269
  36. Marine seaweeds are important sources of drugs with several pharmacological characteristics. The present study aims to evaluate the antitumor and antitumor immunological potentials of the extracts from the bro...

    Authors: Mostafa M. El-Sheekh, Mohamed Nassef, Eman Bases, Shimaa El Shafay and Rania El-shenody
    Citation: Cancer Cell International 2022 22:267
  37. Esophageal cancer is one of the most common cancers with high mortality rate around the world. Although the treatment strategy of this disease has made great progress, the prognosis of advanced patients is not...

    Authors: Zimin Wang, Sikai Wu, Chengchu Zhu and Jianfei Shen
    Citation: Cancer Cell International 2022 22:266
  38. Interaction between tumor cells and tumor microenvironment (TME) is critical to promote tumor progression and metastasis. As the most abundant immune cells in TME, macrophages can be polarized into M2-like tum...

    Authors: Yang Zheng, Shuguang Ren, Yu Zhang, Sihua Liu, Lingjiao Meng, Fei Liu, Lina Gu, Ning Ai and Meixiang Sang
    Citation: Cancer Cell International 2022 22:264
  39. Intra-tumor heterogeneity (ITH) results from the continuous accumulation of mutations during disease progression, thus impacting patients’ clinical outcome. How the ITH evolves across papillary thyroid carcinoma ...

    Authors: Ornella Affinito, Francesca Maria Orlandella, Neila Luciano, Marco Salvatore, Giuliana Salvatore and Monica Franzese
    Citation: Cancer Cell International 2022 22:263
  40. Glioblastoma belongs to the most aggressive type of cancer with a low survival rate that is characterized by the ability in forming a highly immunosuppressive tumor microenvironment. Intercellular communicatio...

    Authors: Mohsen Karami Fath, Jalil Azami, Alireza Masoudi, Reza Mosaddeghi Heris, Elnaz Rahmani, Fatemeh Alavi, Armina Alagheband Bahrami, Zahra Payandeh, Bahman Khalesi, Masoomeh Dadkhah, Navid Pourzardosht and Vahideh Tarhriz
    Citation: Cancer Cell International 2022 22:262
  41. With the combination therapy of PD-1/PD-L1 antibody and antiangiogenic drugs used widely in clinic, a novel method to estimate the prognosis of patients is needed. We aimed to develop a nomogram to examine pro...

    Authors: Hao Huang, Yao Chen, Xuezi Weng, Sirou Li, Lin Zhang and Peisong Chen
    Citation: Cancer Cell International 2022 22:261
  42. As an intelligent disease, tumors apply several pathways to evade the immune system. It can use alternative routes to bypass intracellular signaling pathways, such as nuclear factor-κB (NF-κB), Wnt, and mitoge...

    Authors: Khadijeh Barzaman, Rana Vafaei, Mitra Samadi, Mohammad Hossein Kazemi, Aysooda Hosseinzadeh, Parnaz Merikhian, Shima Moradi-Kalbolandi, Mohammad Reza Eisavand, Houra Dinvari and Leila Farahmand
    Citation: Cancer Cell International 2022 22:259
  43. Naturally, in somatic cells chromosome ends (telomeres) shorten during each cell division. This process ensures to limit proliferation of somatic cells to avoid malignant proliferation; however, it leads to pr...

    Authors: Mohammad Taheri, Soudeh Ghafouri-Fard, Sajad Najafi, Julia Kallenbach, Elmira Keramatfar, Golnaz Atri Roozbahani, Mehdi Heidari Horestani, Bashdar Mahmud Hussen and Aria Baniahmad
    Citation: Cancer Cell International 2022 22:258
  44. Over the past few years, the cancer-related disease has had a high mortality rate and incidence worldwide, despite clinical advances in cancer treatment. The drugs used for cancer therapy, have high side effec...

    Authors: Parina Asgharian, Abbas Pirpour Tazekand, Kamran Hosseini, Haleh Forouhandeh, Tohid Ghasemnejad, Maryam Ranjbar, Muzaffar Hasan, Manoj Kumar, Sohrab Minaei Beirami, Vahideh Tarhriz, Saiedeh Razi Soofiyani, Latipa Kozhamzharova, Javad Sharifi-Rad, Daniela Calina and William C. Cho
    Citation: Cancer Cell International 2022 22:257
  45. Authors: Zeeshan Javed, Khushbukhat Khan, Jesús Herrera-Bravo, Sajid Naeem, Muhammad Javed Iqbal, Haleema Sadia, Qamar Raza Qadri, Shahid Raza, Asma Irshad, Ali Akbar, Željko Reiner, Ahmed Al-Harrasi, Ahmed Al-Rawahi, Dinara Satmbekova, Monica Butnariu, Iulia Cristina Bagiu…
    Citation: Cancer Cell International 2022 22:256

    The original article was published in Cancer Cell International 2021 21:388

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