Skip to main content

Articles

Page 1 of 67

  1. While positive social-behavioral factors predict longer survival in cancer patients, the underlying mechanisms are unknown. Since tumor metastasis are the major cancer mortality factor, we investigated how an ...

    Authors: María Magdalena Canali, Mélanie Guyot, Thomas Simon, Douglas Daoudlarian, Joelle Chabry, Clara Panzolini, Agnès Petit-Paitel, Nicolas Hypolite, Sarah Nicolas, Pierre Bourdely, Heidy Schmid-Antomarchi, Annie Schmid-Alliana, Javier Soria, Babou Karimdjee Soilihi, Paul Hofman, Armelle Prevost-Blondel…
    Citation: Cancer Cell International 2023 23:15
  2. As a prodrug of 5-fluorouracil (5-FU), orally administrated capecitabine (CAP) undergoes preliminary conversion into active metabolites in the liver and then releases 5-FU in the gut to exert the anti-tumor ac...

    Authors: Chun Ge, Xintong Huang, Sujie Zhang, Man Yuan, Zhaoyi Tan, Chen Xu, Qiong Jie, Jingjing Zhang, Jianjun Zou, Yubing Zhu, Dong Feng, Yue Zhang and Jiye Aa
    Citation: Cancer Cell International 2023 23:14
  3. Multiple perioperative inflammatory markers are considered important factors affecting the long-term survival of esophageal cancer (EC) patients. Hematological parameters, whether single or combined, have high...

    Authors: Hui-Ke Wang, Qian Wei, Ya-Lan Yang, Tai-Ying Lu, Yan Yan and Feng Wang
    Citation: Cancer Cell International 2023 23:13
  4. The NF-κB signaling pathway is overactivated in tumor cells, and the activation of the NF-κB signaling pathway releases a large number of inflammatory factors, which enhance tumor immunosuppression and promote...

    Authors: Anqi Zeng, Xinyue Yu, Bao Chen, Lu Hao, Ping Chen, Xue Chen, Yuan Tian, Jing Zeng, Hua Hua, Ying Dai and Junning Zhao
    Citation: Cancer Cell International 2023 23:12
  5. Ovarian cancer (OC) is one of the most common gynecological malignancies with high morbidity and mortality. The peritoneum is one of the most common metastatic sites in ovarian cancer, involving large amounts ...

    Authors: Shuangshuang Mei, Xing Chen, Kai Wang and Yuxin Chen
    Citation: Cancer Cell International 2023 23:11
  6. Recent reports suggested that circulating exosomal microRNAs (exomiRs) may serve as non-invasive prediction biomarkers in gastrointestinal (GI) cancers, yet their clinicopathological and prognostic values need...

    Authors: Elmira Gheytanchi, Fatemeh Tajik, Mahdieh Razmi, Sadegh Babashah, William Chi Shing Cho, Kiarash Tanha, Maryam Sahlolbei, Roya Ghods and Zahra Madjd
    Citation: Cancer Cell International 2023 23:10
  7. Profound resistance to chemotherapy remains a major challenge in achieving better clinical outcomes for patients with pancreatic ductal adenocarcinoma (PDAC). Recent studies indicate that gemcitabine (GEM) res...

    Authors: Manoj Amrutkar, Kjersti Berg, Aina Balto, Miguel G. Skilbrei, Anette V. Finstadsveen, Monica Aasrum, Ivar P. Gladhaug and Caroline S. Verbeke
    Citation: Cancer Cell International 2023 23:9
  8. Antisense oligonucleotide (ASO) medicine for clinical applications has been becoming a reality. We previously developed a gapmer ASO targeting Ser/Arg repetitive matrix 4 (SRRM4) that is abnormally expressed i...

    Authors: Misa Yoshida, Chihiro Oda, Keishiro Mishima, Itsuki Tsuji, Satoshi Obika and Masahito Shimojo
    Citation: Cancer Cell International 2023 23:8
  9. Multiple molecular subtypes with distinct clinical outcomes in pancreatic adenocarcinoma (PAAD) have been identified in recent years. Cuproptosis is a new form of cell death that likely involved in tumor progr...

    Authors: Jian Li, Jingyang Yin, Wenhua Li, Huaizhi Wang and Bing Ni
    Citation: Cancer Cell International 2023 23:7
  10. Chemotherapy resistance is an important bottleneck affecting the efficacy of chemotherapy in colon cancer. Therefore, improving the chemotherapy sensitivity of colorectal cancer cells is of great significance ...

    Authors: Jun Ying, Haiyang Zhou, Zhiguo Wang, Qing You, Junnan Chen, Hao Lu and Jian Zhang
    Citation: Cancer Cell International 2023 23:6
  11. Glioblastoma is one of the malignant tumors of the central nervous system with high lethality, high disability and low survival rate. Effective induction of its death is one of the existing challenges. In rece...

    Authors: Kai Zhang, Yue Wu, Guangliang Chen, Hao Wang, Yongsheng Liu and Youxin Zhou
    Citation: Cancer Cell International 2023 23:5
  12. The three most common gynaecologic cancers that seriously threaten female lives and health are ovarian cancer, cervical cancer, and endometrial cancer. Glycolysis plays a vital role in gynaecologic cancers. Se...

    Authors: Nengyuan Lv, Siyi Shen, Qianying Chen and Jinyi Tong
    Citation: Cancer Cell International 2023 23:4
  13. Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are devastating primary liver cancers with increasing prevalence in many parts of the world. Despite intense investigation, many aspects of their bi...

    Authors: Tomasz Gromowski, Veronika Lukacs-Kornek and Jaroslaw Cisowski
    Citation: Cancer Cell International 2023 23:3
  14. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. The molecules (proteins, metabolites) secreted by tumors affect their extracellular milieu to support cancer progression. If ...

    Authors: Piotr Poplawski, Saleh Alseekh, Urszula Jankowska, Bozena Skupien-Rabian, Roksana Iwanicka-Nowicka, Helena Kossowska, Anna Fogtman, Beata Rybicka, Joanna Bogusławska, Anna Adamiok-Ostrowska, Karolina Hanusek, Jan Hanusek, Marta Koblowska, Alisdair R. Fernie and Agnieszka Piekiełko-Witkowska
    Citation: Cancer Cell International 2023 23:2
  15. Squamous cell carcinomas are the most common head and neck malignancies. Significant progress has been made in standard therapeutic methods combining surgery, radiation, and chemotherapy. Nevertheless, the 5-y...

    Authors: Hui Dong, Mengli Li, Chen Yang, Wei Wei, Xianglei He, Gang Cheng and Shibing Wang
    Citation: Cancer Cell International 2023 23:1
  16. Breast cancer stem cells (BCSCs) have a crucial role in breast carcinogenesis, development, and progression. The aim of the current study is to characterize the BCSCs through the genetic profiling of different...

    Authors: Abdel-Rahman N. Zekri, Abeer Bahnassy, Magda Mourad, Ibrahim Malash, Ola Ahmed and Mona S. Abdellateif
    Citation: Cancer Cell International 2022 22:423
  17. The endogenous tissue inhibitor of metalloproteinase-2 (TIMP-2), through its homeostatic action on certain metalloproteinases, plays a vital role in remodelling extracellular matrix (ECM) to facilitate cancer ...

    Authors: Ruth M. Escalona, Simon Chu, Elif Kadife, Jason K. Kelly, George Kannourakis, Jock K. Findlay and Nuzhat Ahmed
    Citation: Cancer Cell International 2022 22:422
  18. Hyaluronic acid (HA) promotes cancer metastasis; however, the currently approved treatments do not target HA. Metastatic renal carcinoma (mRCC) is an incurable disease. Sorafenib (SF) is a modestly effective a...

    Authors: Jiaojiao Wang, Andre R. Jordan, Huabin Zhu, Sarrah L. Hasanali, Eric Thomas, Soum D. Lokeshwar, Daley S. Morera, Sung Alexander, Joseph McDaniels, Anuj Sharma, Karina Aguilar, Semih Sarcan, Tianyi Zhu, Mark S. Soloway, Martha K. Terris, Muthusamy Thangaraju…
    Citation: Cancer Cell International 2022 22:421
  19. Melatonin is a neuro-hormone with conserved roles in evolution. Initially synthetized as an antioxidant molecule, it has gained prominence as a key molecule in the regulation of the circadian rhythm. Melatonin...

    Authors: Ainaz Mihanfar, Bahman Yousefi, Bita Azizzadeh and Maryam Majidinia
    Citation: Cancer Cell International 2022 22:420
  20. Cancer is a heterogeneous disease with multifaceted drug resistance mechanisms (e.g., tumour microenvironment [TME], tumour heterogeneity, and immune evasion). Natural products are interesting repository of bi...

    Authors: Mohammed Moustapha Anwar, Chris Albanese, Nadia M. Hamdy and Ahmed S. Sultan
    Citation: Cancer Cell International 2022 22:419
  21. Patients with intrahepatic cholangiocarcinoma (ICC) require chemotherapy due to late detection, rapid disease progression, and low surgical resection rate. Tumor cell lines are extremely important in cancer re...

    Authors: Xin Miao, Jinjing Hu, Changpeng Chai, Huan Tang, Zhenjie Zhao, Wei Luo, Wence Zhou and Hao Xu
    Citation: Cancer Cell International 2022 22:418
  22. Pancreatic cancer is one of the most aggressive malignancies without effective targeted therapies. MUC1 has emerged as a potential common target for cancer therapy because it is overexpressed in a variety of d...

    Authors: Guang Wu, Lan Li, Mengnan Liu, Chunyan Chen, Guangze Wang, Zewei Jiang, Yaqian Qin, Licai He, Hongzhi Li, Jiawei Cao and Haihua Gu
    Citation: Cancer Cell International 2022 22:417
  23. The tumor suppressor p53 when undergoes amyloid formation confers several gain-of-function (GOF) activities that affect molecular pathways crucial for tumorigenesis and progression like some of the p53 mutants...

    Authors: Shinjinee Sengupta, Shaikh Maryam Ghufran, Aqsa Khan, Subhrajit Biswas and Susanta Roychoudhury
    Citation: Cancer Cell International 2022 22:416
  24. MicroRNAs (miRNAs), as an indispensable type of non-coding RNA (ncRNA), participate in diverse biological processes. However, the specific regulatory mechanism of certain miRNAs in pancreatic ductal adenocarci...

    Authors: Bojing Chi, Yao Zheng, Fuming Xie, Wen Fu, Xianxing Wang, Jianyou Gu, Jiali Yang, Jingyang Yin, Lei Cai, Peng Tang, Jianbo Li, Shixiang Guo and Huaizhi Wang
    Citation: Cancer Cell International 2022 22:415
  25. Mass spectrometry imaging (MSI) enables obtaining multidimensional results simultaneously in a single run, including regiospecificity and m/z values corresponding with specific proteins, peptides, lipids, etc. Th...

    Authors: Dagmara Pietkiewicz, Szymon Plewa, Mikołaj Zaborowski, Timothy J. Garrett, Eliza Matuszewska, Zenon J. Kokot and Jan Matysiak
    Citation: Cancer Cell International 2022 22:414
  26. As a member of the miR-1 family, miR-206 is located between IL-17 and PKHD1 genes in human. This miRNA has been shown to be involved in the pathogenic processes in a variety of human disorders including cancers, ...

    Authors: Sheyda Khalilian, Seyedeh Zahra Hosseini Imani and Soudeh Ghafouri-Fard
    Citation: Cancer Cell International 2022 22:412
  27. Glioblastoma (GBM) is the most malignant, aggressive and recurrent primary brain tumor. Cell senescence can cause irreversible cessation of cell division in normally proliferating cells. According to studies, ...

    Authors: Chenyang Tan, Yan Wei, Xuan Ding, Chao Han, Zhongzheng Sun and Chengwei Wang
    Citation: Cancer Cell International 2022 22:411
  28. Colorectal cancer (CRC) is the third most revalent type of cancer in the world and the second most common cause of cancer death (about 1 million per year). Historically, natural compounds and their structural ...

    Authors: Stefania Garzoli, Pedro Alarcón-Zapata, Gulnaz Seitimova, Barbara Alarcón-Zapata, Miquel Martorell, Farukh Sharopov, Patrick Valere Tsouh Fokou, Darline Dize, Lauve Rachel Tchokouaha Yamthe, Francisco Les, Guillermo Cásedas, Víctor López, Marcello Iriti, Javad Sharifi Rad, Eda Sönmez Gürer, Daniela Calina…
    Citation: Cancer Cell International 2022 22:407
  29. In-situ tumor ablation provides the immune system with the appropriate antigens to induce anti-tumor immunity. Here, we present an innovative technique for generating anti-tumor immunity by delivering exogenou...

    Authors: Hila Confino, Frederick M. Dirbas, Matan Goldshtein, Shay Yarkoni, Rinat Kalaora, Meital Hatan, Shani Puyesky, Yakir Levi, Lidor Malka, Matt Johnson, Selena Chaisson, Jedidiah M. Monson, Amir Avniel, Steve Lisi, David Greenberg and Ido Wolf
    Citation: Cancer Cell International 2022 22:405
  30. Cancer-associated fibroblasts (CAFs) coordinate the malignancy of cancer cells via secretory materials. Reprogrammed lipid metabolism and signaling play critical roles in cancer biology. Oleic acid (OA) serves...

    Authors: Sung-Hyun Hwang, Yeseul Yang, Jae-Ha Jung and Yongbaek Kim
    Citation: Cancer Cell International 2022 22:404
  31. Metabolic reprogramming is an important issue in tumor biology. A recently-identified actor in this regard is the molecular chaperone TRAP1, that is considered an oncogene in several cancers for its high expre...

    Authors: Danilo Swann Matassa, Daniela Criscuolo, Rosario Avolio, Ilenia Agliarulo, Daniela Sarnataro, Consiglia Pacelli, Rosella Scrima, Alessandra Colamatteo, Giuseppe Matarese, Nazzareno Capitanio, Matteo Landriscina and Franca Esposito
    Citation: Cancer Cell International 2022 22:402
  32. Programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockade therapy has become a game-changing therapeutic approach revolutionizing the treatment setting of human malignancies, such as renal cell carc...

    Authors: Mohammadsaleh Jahangir, Omid Yazdani, Mohammad Saeed Kahrizi, Sara Soltanzadeh, Hamidreza Javididashtbayaz, Azam Mivefroshan, Saba Ilkhani and Romina Esbati
    Citation: Cancer Cell International 2022 22:401
  33. Papillary thyroid cancer (PTC) is the most frequent thyroid tumor. The tissue inhibitor of metalloproteinase-3 (TIMP3) gene encodes a matrix metalloproteinases inhibitor that exerts a tumor suppressor role in ...

    Authors: M. Mazzoni, K. Todoerti, L. Agnelli, E. Minna, S. Pagliardini, T. Di Marco, M. G. Borrello, A. Neri and A. Greco
    Citation: Cancer Cell International 2022 22:400
  34. Incidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the development of resistance against currently available treatment strategies has contributed to the cancer-associated mortality....

    Authors: Sameen Zafar, Khushbukhat Khan, Amna Hafeez, Muhammad Irfan, Muhammad Armaghan, Anees ur Rahman, Eda Sönmez Gürer, Javad Sharifi-Rad, Monica Butnariu, Iulia-Cristina Bagiu and Radu Vasile Bagiu
    Citation: Cancer Cell International 2022 22:399
  35. Hyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic endothelial cells and specialized macrophages. Besides binding to hyaluronan, LYVE-1 can mediate adhesion of leuk...

    Authors: Anna Sophia Jauch, Sebastian A. Wohlfeil, Céline Weller, Bianca Dietsch, Verena Häfele, Ana Stojanovic, Maximilian Kittel, Hendrik Nolte, Adelheid Cerwenka, Michael Neumaier, Kai Schledzewski, Carsten Sticht, Philipp-Sebastian Reiners-Koch, Sergij Goerdt and Cyrill Géraud
    Citation: Cancer Cell International 2022 22:398
  36. Simplistic two-dimensional (2D) in vitro assays have long been the standard for studying the metastatic abilities of cancer cells. However, tri-dimensional (3D) organotypic models provide a more complex enviro...

    Authors: Sabrina J. Ritch, Abu Shadat M. Noman, Alicia A. Goyeneche and Carlos M. Telleria
    Citation: Cancer Cell International 2022 22:397
  37. Papillary thyroid cancer (PTC) is the most common endocrine malignancy with a fast-growing incidence in recent decades. HOTAIR as a long non-coding RNA has been shown to be highly expressed in papillary thyroid c...

    Authors: Feng-Chih Kuo, Yu-Ting Wang, Chia-Hsin Liu, Yao-Feng Li, Chieh-Hua Lu, Sheng-Chiang Su, Jhih-Syuan Liu, Peng-Fei Li, Chia-Luen Huang, Li-Ju Ho, Chien-Ming Lin and Chien-Hsing Lee
    Citation: Cancer Cell International 2022 22:396
  38. Dystroglycan (DG) is a glycoprotein composed of two subunits that remain non-covalently bound at the plasma membrane: α-DG, which is extracellular and heavily O-mannosyl glycosylated, and β-DG, an integral transm...

    Authors: Cristina Quereda, Àngels Pastor and José Martín-Nieto
    Citation: Cancer Cell International 2022 22:395
  39. The dysregulation of CD5L has been reported in hepatocellular carcinoma (HCC). However, its functions in HCC were controversial. In this study, we aimed to identify CD5L-associated pathways and markers and exp...

    Authors: Xiuzhi Zhang, Xiaoli Liu, Keke Zhu, Xue Zhang, Ningning Li, Tao Sun, Shasha Fan, Liping Dai and Jinzhong Zhang
    Citation: Cancer Cell International 2022 22:393
  40. The tumor microenvironment is one of the most important factors determining the efficacy of cancer immunotherapy. In particular, variability in efficacy has been linked to whether tumors are hot or cold, with ...

    Authors: Takayuki Horii, Yuki Orikawa, Yuta Ohira, Runa Eta, Nobuyoshi Kobayashi, Takanori Sato, Takeshi Watanabe and Takao Tanaka
    Citation: Cancer Cell International 2022 22:392
  41. Cervical cancer is the second most common cancer in women and causes more than 250,000 deaths worldwide. Among these, the incidence of cervical adenocarcinomas is increasing. Cervical adenocarcinoma is not onl...

    Authors: Kazumasa Sekihara, Hidetomo Himuro, Nao Saito, Yukihide Ota, Taku Kouro, Yohsuke Kusano, Shinichi Minohara, Ryoichi Hirayama, Hiroyuki Katoh, Tetsuro Sasada and Daisuke Hoshino
    Citation: Cancer Cell International 2022 22:391
  42. Anaplastic thyroid carcinoma (ATC) is the most aggressive subtype of thyroid cancer. In this study, we used a three-dimensional in vitro system to evaluate the effect of a dual MEK/Aurora kinase inhibitor, BI-...

    Authors: Hilda Samimi, Rezvan Tavakoli, Parviz Fallah, Alireza Naderi Sohi, Maryam Amini Shirkouhi, Mahmood Naderi and Vahid Haghpanah
    Citation: Cancer Cell International 2022 22:388
  43. Therapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as polyphenols. Luteolin is a flavone belonging to the flavonoid class of...

    Authors: Parteek Prasher, Mousmee Sharma, Sachin Kumar Singh, Monica Gulati, Dinesh Kumar Chellappan, Flavia Zacconi, Gabriele De Rubis, Gaurav Gupta, Javad Sharifi-Rad, William C. Cho and Kamal Dua
    Citation: Cancer Cell International 2022 22:386

Annual Journal Metrics

Institutional membership

Visit the membership page to check if your institution is a member and learn how you could save on article-processing charges (APCs).

Funding your APC

​​​​​​​Open access funding and policy support by SpringerOpen​​

​​​​We offer a free open access support service to make it easier for you to discover and apply for article-processing charge (APC) funding. Learn more here