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  1. Content type: Primary research

    Monoclonal antibodies targeting programmed death-1 receptor (PD-1) and its ligand (PD-L1) have been developed to treat cancers including lung cancer. In this study, we aimed to investigate whether lycopene cou...

    Authors: Xiufeng Jiang, Hui Wu, Wei Zhao, Xiao Ding, Qian You, Feng Zhu, Meifang Qian and Ping Yu

    Citation: Cancer Cell International 2019 19:68

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  2. Content type: Primary research

    Low molecular weight protein tyrosine phosphatase (LMW-PTP) is overexpressed in different cancer types and its expression is related to more aggressive disease, reduced survival rate and drug resistance. Morin...

    Authors: Nagaja Capitani, Giulia Lori, Paolo Paoli, Laura Patrussi, Arianna Troilo, Cosima T. Baldari, Giovanni Raugei and Mario Milco D’Elios

    Citation: Cancer Cell International 2019 19:67

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  3. Content type: Primary research

    The ovarian cancer microenvironment is responsible for cancer cell growth and disease relapse. Bone marrow mesenchymal stem cells (BM-MSCs) play important roles in ovarian cancer, however, the mechanism of BM-...

    Authors: Jinghui Hu, Wei Zhao, Yujie Huang, Zhe Wang, Tingting Jiang and Li Wang

    Citation: Cancer Cell International 2019 19:66

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  4. Content type: Primary research

    Xinjiang is one of the areas with the highest incidence of cervical cancer in China. Genetic variation in Human papillomavirus type 16 (HPV16) may increase the ability of the virus to mediate carcinogenesis an...

    Authors: Xiangyi Zhe, Huizhen Xin, Zhenzhen Pan, Fuyuan Jin, Weinan Zheng, Hongtao Li, Dongmei Li, Dongdong Cao, Ying Li, Chunhe Zhang, Shaowei Fu, Renfu Shao and Zemin Pan

    Citation: Cancer Cell International 2019 19:65

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  5. Content type: Primary research

    Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful comp...

    Authors: Jia-Jie Tan, Lu Wang, Ting-Ting Mo, Jie Wang, Mei-Gui Wang and Xiang-Ping Li

    Citation: Cancer Cell International 2019 19:64

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  6. Content type: Primary research

    Mitogen-activated protein kinase phosphatases-4 (MKP-4) is reported to exert a prognostic merit in hepatocarcinogenesis. However, the underlying molecular mechanisms have not been clearly defined.

    Authors: Zhongyi Shen, Chengliang Zhang, Lishuai Qu, Cuihua Lu, Mingbing Xiao, Runzhou Ni and Jinxia Liu

    Citation: Cancer Cell International 2019 19:61

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  7. Content type: Primary research

    Effective therapy for hepatocellular carcinoma (HCC) is currently an imperative issue, and sorafenib is a first-line drug for the treatment of HCC. However, the clinical benefit of sorafenib is often impaired ...

    Authors: Jie Song, Wei Zhao, Chang Lu and Xue Shao

    Citation: Cancer Cell International 2019 19:60

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  8. Content type: Primary research

    Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) de...

    Authors: Qinghe Zhao, Wuliang Wang and Jinquan Cui

    Citation: Cancer Cell International 2019 19:58

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  9. Content type: Primary research

    The tripartite motif (TRIM) family proteins are implicated in the pathogenesis of various human malignancies. The up-regulation and oncogenic roles of TRIM52 have been reported in hepatocellular carcinoma. In ...

    Authors: Shengli Pan, Yingying Deng, Jun Fu, Yuhao Zhang, Zhijin Zhang, Xiaokun Ru and Xianju Qin

    Citation: Cancer Cell International 2019 19:57

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  10. Content type: Primary research

    T-cell acute lymphoblastic leukemia (T-ALL) is a lymphoid malignancy caused by the oncogenic transformation of immature T-cell progenitors with poor outcomes. WP1130 has shown potent activity against a variety...

    Authors: Hao Luo, Bo Jing, Yu Xia, Yugen Zhang, Meng Hu, Haiyan Cai, Yin Tong, Li Zhou, Li Yang, Junmei Yang, Hu Lei, Hanzhang Xu, Chuanxu Liu and Yingli Wu

    Citation: Cancer Cell International 2019 19:56

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  11. Content type: Primary research

    Dishevelled-associated activator of morphogenesis 1 (DAAM1) is a member of microfilament-related formins and mediates cell motility in breast cancer (BrCa). However, the genetic mutation status of DAAM1 mRNA and ...

    Authors: Jie Mei, Ting Yan, Yifu Huang, Tiansong Xia, Fei Chang, Shuning Shen, Leiyu Hao, Yin Chen, Zhongyuan Wang, Xiaozheng Jiang, Bujie Xu and Yichao Zhu

    Citation: Cancer Cell International 2019 19:55

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  12. Content type: Primary research

    Current chemotherapy for castration-resistant prostate cancer is established on taxane-based compounds like docetaxel. However, eventually, the development of toxic side effects and resistance limits the thera...

    Authors: Belén G. Sánchez, Alicia Bort, Pedro A. Mateos-Gómez, Nieves Rodríguez-Henche and Inés Díaz-Laviada

    Citation: Cancer Cell International 2019 19:54

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  13. Content type: Primary research

    Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with target...

    Authors: Chiao-En Wu, Tsin Shue Koay, Yi-Hsuan Ho, Penny Lovat and John Lunec

    Citation: Cancer Cell International 2019 19:53

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  14. Content type: Primary research

    Aberrant DNA methylations are significantly associated with esophageal squamous cell carcinoma (ESCC). In this study, we aimed to investigate the DNA methylation-driven genes in ESCC by integrative bioinformat...

    Authors: Tong Lu, Di Chen, Yuanyong Wang, Xiao Sun, Shicheng Li, Shuncheng Miao, Yang Wo, Yanting Dong, Xiaoliang Leng, Wenxing Du and Wenjie Jiao

    Citation: Cancer Cell International 2019 19:52

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  15. Content type: Primary research

    Methylation plays a key role in the aetiology and pathogenesis of prostate cancer (PCa). This study aimed to identify aberrantly methylated differentially expressed genes (DEGs) and pathways in PCa and explore...

    Authors: Kai Wu, Xiaotao Yin, Yipeng Jin, Fangfang Liu and Jiangping Gao

    Citation: Cancer Cell International 2019 19:51

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  16. Content type: Primary research

    Prostate cancer (PCa) is a malignancy cause of cancer deaths and frequently diagnosed in male. This study aimed to identify tumor suppressor genes, hub genes and their pathways by combined bioinformatics analy...

    Authors: Yanqiu Tong, Yang Song and Shixiong Deng

    Citation: Cancer Cell International 2019 19:50

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  17. Content type: Primary research

    Hepatocyte nuclear factor 4α (HNF4α) is a tissue-specific transcription factor that regulates the expression of numerous genes in hepatocytes and pancreatic β cells. HNF4α has been reported to affect cell prol...

    Authors: Qiqing Sun, Wenyan Xu, Shunrong Ji, Yi Qin, Wensheng Liu, Qiangsheng Hu, Zheng Zhang, Mengqi Liu, Xianjun Yu and Xiaowu Xu

    Citation: Cancer Cell International 2019 19:49

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  18. Content type: Primary research

    Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck region with poorly understood progression and prognosis. The present study aims at exploring whether the expression of β-catenin,...

    Authors: Pei-Ying Jin, Zi-Hui Zheng, Hong-Jie Lu, Jing Yan, Gui-Hong Zheng, Yuan-Lin Zheng, Dong-Mei Wu and Jun Lu

    Citation: Cancer Cell International 2019 19:48

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  19. Content type: Primary research

    Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense R...

    Authors: Dawei Jiang, Liu Xu, Jianqi Ni, Jie Zhang, Min Cai and Lan Shen

    Citation: Cancer Cell International 2019 19:47

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  20. Content type: Primary research

    Among breast cancer (BC) patients the outcomes of anticancer therapy vary dramatically due to the highly heterogeneous molecular characteristics of BC. Therefore, an extended panel of BC cell lines are require...

    Authors: Anna A. Nushtaeva, Anastasia A. Karpushina, Mikhail S. Ermakov, Ludmila F. Gulyaeva, Alexey V. Gerasimov, Sergey V. Sidorov, Tatyana A. Gayner, Anastasia Y. Yunusova, Anastasia V. Tkachenko, Vladimir A. Richter and Olga A. Koval

    Citation: Cancer Cell International 2019 19:46

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  21. Content type: Primary research

    The study purpose was to make investigation into the influence of XIST on cervical cancer progression and what’s more its potential mechanism.

    Authors: Xing Chen, Dongsheng Xiong, Liya Ye, Kai Wang, Lingfei Huang, Shuangshuang Mei, Jinhong Wu, Shanshan Chen, Xiaoli Lai, Lingzhi Zheng and Meifen Wang

    Citation: Cancer Cell International 2019 19:45

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  22. Content type: Primary research

    FOXD3 is aberrantly regulated in several tumors, but its underlying mechanisms in ovarian cancer (OC) remains largely unknown. The present study aimed to explore the role and associated mechanisms of FOXD3 in OC.

    Authors: Gui-fang Luo, Chang-ye Chen, Juan Wang, Hai-yan Yue, Yong Tian, Ping Yang, Yu-kun Li and Yan Li

    Citation: Cancer Cell International 2019 19:44

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  23. Content type: Primary research

    Thyroid cancer is the most common type of endocrine malignancy and the incidence rate is rapidly increasing worldwide. Epigallocatechin-3-gallate (EGCG) could suppress cancer growth and induce apoptosis in man...

    Authors: Dongdong Wu, Zhengguo Liu, Jianmei Li, Qianqian Zhang, Peiyu Zhong, Tieshan Teng, Mingliang Chen, Zhongwen Xie, Ailing Ji and Yanzhang Li

    Citation: Cancer Cell International 2019 19:43

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  24. Content type: Primary research

    Human bladder cancer is one of the common malignant tumors, and it mainly occurs in men. miR-182-5p, a member of miR-183 family, acts as tumor suppressor or oncogene in various kinds of tumors. In this study, ...

    Authors: Fei Wang, Dinglan Wu, Zhanping Xu, Jianxiang Chen, Jiye Zhang, Xiaojuan Li, Shiliang Chen, Fengrong He, Jianbing Xu, Liangju Su, Defan Luo, Shufang Zhang and Weifu Wang

    Citation: Cancer Cell International 2019 19:42

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  25. Content type: Primary research

    Angiogenic factor with G-patch and FHA domain 1 (AGGF1), as a newly identified human angiogenic factor, is overexpressed in some types of malignant tumors and closely associated with patient’s prognosis. Howev...

    Authors: Han-Hui Yao, Ya-Jun Zhao, Yi-Fu He, Da-Bing Huang and Wei Wang

    Citation: Cancer Cell International 2019 19:41

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  26. Content type: Primary research

    The abnormal expression of many long non-coding RNAs (lncRNAs) has been reported in the progression of various tumors. However, the potential biological roles and regulatory mechanisms of long non-coding RNAs ...

    Authors: Qingmei Wang, Rongzhang He, Tan Tan, Jia Li, Zheng Hu, Weihao Luo, Lili Duan, Wenna Luo and Dixian Luo

    Citation: Cancer Cell International 2019 19:40

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  27. Content type: Primary research

    Accumulating studies have focused on the oncogenic roles of the newly identified lncRNAs in human cancers. The aim of this study was to examine the expression pattern of Linc00959 in BC and to evaluate its bio...

    Authors: Weiru Chi, Sheng Huang, Bingqiu Xiu, Qi Zhang, Zhiming Shao, Jiong Wu and Yayun Chi

    Citation: Cancer Cell International 2019 19:39

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  28. Content type: Primary research

    The staging system of nasopharyngeal carcinoma (NPC) has close relationship with the degree of cell differentiation, but most NPC patients remain undiagnosed until advanced phases. Novel metabolic markers need...

    Authors: Yang Chen, Zhong Chen, Ying Su, Donghong Lin, Min Chen, Shangyuan Feng and Changyan Zou

    Citation: Cancer Cell International 2019 19:37

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  29. Content type: Primary research

    Radiation therapy remains an important therapeutic modality, especially for those patients who are not candidates for radical resection. Many strategies have been developed to increase the radiosensitivity of ...

    Authors: Wen-Xiu Ding, Shu Liu, Jian-Xin Ma, Juan Pu, Hai-Jing Wang, Shu Zhang and Xin-chen Sun

    Citation: Cancer Cell International 2019 19:36

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  30. Content type: Primary research

    Voltage-gated sodium (NaV) channels are heteromeric proteins consisting of a single pore forming α-subunit associated with one or two auxiliary β-subunits. These channels are classically known for being responsib...

    Authors: Ana Laura Sanchez-Sandoval and Juan Carlos Gomora

    Citation: Cancer Cell International 2019 19:35

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  31. Content type: Primary research

    SLC25A22, a member of mitochondrial carrier system (MCS) family encoding a mitochondrial glutamate transporter, has been reported to have vital roles in promoting proliferation and migration in cancer. Gallbla...

    Authors: Pengcheng Du, Haibin Liang, Xiaowei Fu, Peng Wu, Chao Wang, Haimin Chen, Bingbing Zheng, Jun Zhang, Shuanghui Hu, Rengui Zeng, Bo Liang and Lu Fang

    Citation: Cancer Cell International 2019 19:33

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  32. Content type: Primary research

    Angioimmunoblastic T cell lymphoma (AITL) is a distinct subtype of peripheral T cell lymphoma and associated with poor outcomes. The activation status of T cell receptor (TCR) signaling has recently become a f...

    Authors: Yalu Liu, Xiaogan Wang, Lijuan Deng, Lingyan Ping, Yunfei Shi, Wen Zheng, Ningjing Lin, Xiaopei Wang, Meifeng Tu, Yan Xie, Weiping Liu, Zhitao Ying, Chen Zhang, Zhengying Pan, Xi Wang, Ning Ding…

    Citation: Cancer Cell International 2019 19:32

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  33. Content type: Primary research

    This study aims to investigate the role of microRNA-92a (miR-92a) in metastasis of osteosarcoma (OS) cells in vivo and in vitro by regulatingTCF21 with the transmission of bone marrow derived mesenchymal stem ...

    Authors: Shuai Cao, Liangde Jiang, Lulu Shen and Zhizheng Xiong

    Citation: Cancer Cell International 2019 19:31

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  34. Content type: Correction

    Following publication of the original article [1], the authors notified us of an error in the spelling of second author’s name. The correct name spelling is Suad A. Telity.

    Authors: Abdel-Moneim M. Osman, Suad A. Telity, Zoheir A. Damanhouri, Sameer E. Al-Harthy, Huda M. Al-Kreathy, Wafaa S. Ramadan, Mohamed F. Elshal, Lateef M. Khan and Fatemah Kamel

    Citation: Cancer Cell International 2019 19:30

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    The original article was published in Cancer Cell International 2015 15:6

  35. Content type: Correction

    Following publication of the original article [1], the authors would like to make an amendment to the Acknowledgements section.

    Authors: Evita G. Weagel, Weston Burrup, Roman Kovtun, Edwin J. Velazquez, Abigail M. Felsted, Michelle H. Townsend, Zachary E. Ence, Erica Suh, Stephen R. Piccolo, K. Scott Weber, Richard A. Robison and Kim L. O’Neill

    Citation: Cancer Cell International 2019 19:29

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    The original article was published in Cancer Cell International 2018 18:135

  36. Content type: Primary research

    Bisphosphonates (BPs) including zoledronate (zol) have become standard care for bone metastases as they effectively inhibit tumor-induced osteolysis and associated pain. Several studies have also suggested tha...

    Authors: Elie Akoury, Pouyan Ahangar, Antone Nour, Jacques Lapointe, Karl-Philippe Guérard, Lisbet Haglund, Derek H. Rosenzweig and Michael H. Weber

    Citation: Cancer Cell International 2019 19:28

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  37. Content type: Primary research

    Currently, cancer-related competing endogenous RNA (ceRNA) networks are attracting significant interest. As long noncoding RNA ZEB1-AS1 has been reported to function as an oncogene due to sponging microRNAs (m...

    Authors: Ming-Hui Ma, Jia-Xiang An, Cheng Zhang, Jie Liu, Yu Liang, Chun-Dong Zhang, Zhen Zhang and Dong-Qiu Dai

    Citation: Cancer Cell International 2019 19:27

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  38. Content type: Primary research

    Patients diagnosed with triple negative breast cancer (TNBC) have limited treatment options and often suffer from resistance and toxicity due to chemotherapy. We previously found that depleting calcium and int...

    Authors: Alexander H. Chung, Tina M. Leisner, Gabrielle J. Dardis, Marissa M. Bivins, Alana L. Keller and Leslie V. Parise

    Citation: Cancer Cell International 2019 19:26

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  39. Content type: Primary research

    Increasing studies indicated that circRNAs play critical roles in tumor progression. However, the roles and underlying mechanisms of circRNAs in gastric cancer (GC) remain largely unclear.

    Authors: Minghui Xue, Guangyan Li, Xiangjie Fang, Lili Wang, Yuhong Jin and Qinglan Zhou

    Citation: Cancer Cell International 2019 19:25

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  40. Content type: Primary research

    Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer. Both animal and clinical studies have revealed that bile acid reflux and subsequent chronic inflammation are key causal facto...

    Authors: Ting Yuan, Zhen Ni, Chuan Han, Yali Min, Nina Sun, Caifang Liu, Miao Shi, Wenquan Lu, Na Wang, Feng Du, Qiong Wu, Ning Xie and Yongquan Shi

    Citation: Cancer Cell International 2019 19:24

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  41. Content type: Review

    Inflammatory breast cancer (IBC) is an infrequent but aggressive manifestation of breast cancer, which accounts for 2–4% of all breast cancer cases but responsible for 7–10% of breast cancer-related deaths, an...

    Authors: Yihang Qi, Xiangyu Wang, Xiangyi Kong, Jie Zhai, Yi Fang, Xiaoxiang Guan and Jing Wang

    Citation: Cancer Cell International 2019 19:23

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  42. Content type: Primary research

    Circulating tumor cells (CTCs) have been described as a population of cells that may seed metastasis, which is a reliable target for the prevention of metastases in lung cancer patients at the early stage. The...

    Authors: Zujun Que, Bin Luo, Zhiyi Zhou, Changsheng Dong, Yi Jiang, Lin Wang, Qihui Shi and Jianhui Tian

    Citation: Cancer Cell International 2019 19:21

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  43. Content type: Primary research

    Increasingly evidences suggest that long noncoding RNAs (lncRNAs) play important roles in various cancers. LncRNA PXN-AS1-L is recently revealed to act as on oncogene in liver cancer. However, the expression, ...

    Authors: Zhifa Zhang, Zhaohui Peng, Junying Cao, Jiaqi Wang, Yongyu Hao, Kai Song, Yan Wang, Wei Hu and Xuesong Zhang

    Citation: Cancer Cell International 2019 19:20

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