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  1. Rearrangements involving the fibroblast growth factor receptor 1 (FGFR1) gene result in 8p11 myeloproliferative syndrome (EMS), which is a rare and aggressive hematological malignancy that is often initially d...

    Authors: Xuehong Zhang, Furong Wang, Fanzhi Yan, Dan Huang, Haina Wang, Beibei Gao, Yuan Gao, Zhijie Hou, Jiacheng Lou, Weiling Li and Jinsong Yan

    Citation: Cancer Cell International 2022 22:40

    Content type: Primary research

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  2. Theabrownin (TB) is a bioactive component of tea and has been reported to exert effects against many human cancers, but its efficacy and mechanism on hepatocellular carcinoma (HCC) with different p53 genotypes...

    Authors: Jiaan Xu, Xiujuan Xiao, Bo Yan, Qiang Yuan, Xiaoqiao Dong, Quan Du, Jin Zhang, Letian Shan, Zhishan Ding, Li Zhou and Thomas Efferth

    Citation: Cancer Cell International 2022 22:39

    Content type: Primary research

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  3. The tumour heterogeneous make-up of immune cell infiltrates is a key factor for the therapy response and prognosis of hepatocellular carcinoma (HCC). However, it is still a major challenge to comprehensively u...

    Authors: Juan Lu, Yanfei Chen, Xiaoqian Zhang, Jing Guo, Kaijin Xu and Lanjuan Li

    Citation: Cancer Cell International 2022 22:38

    Content type: Primary research

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  4. To determine whether concurrent chemotherapy is necessary during locoregional radiotherapy (RT) after palliative chemotherapy (PCT) in patients with de novo metastatic nasopharyngeal carcinoma (mNPC).

    Authors: Shuo-Han Zheng, Yu-Tong Wang, Song-Ran Liu, Zi-Lu Huang, Guan-Nan Wang, Jin-Tao Lin, Shi-Rong Ding, Chen Chen and Yun-Fei Xia

    Citation: Cancer Cell International 2022 22:36

    Content type: Primary research

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  5. Golgi phosphoprotein 3 (GOLPH3) has been frequently reported as an oncoprotein in a variety of tumors. However, its role in the cancer-associated intercellular signaling communication has not yet been explored...

    Authors: Ying Gao, Zheng Yin, Yunling Qi, Hong Peng, Wenbin Ma, Ruizhi Wang and Wen Li

    Citation: Cancer Cell International 2022 22:35

    Content type: Primary research

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  6. Silencing of the periostin gene (POSTN) can inhibit the biological process of several different cancers, and this inhibition may be related to down-regulation of PI3K/AKT signaling. However, the effect of POSTN o...

    Authors: Chaojian Xu, Ziyue Wang, Long Zhang, Yi Feng, Jia Lv, Zhuangzhuang Wu, Rong Yang, Taiyong Wu, Jian Li, Ruhao Zhou, Zhi Tian, Junjun Bai, Huadong Zhang, Yanping Lan and Zhi Lv

    Citation: Cancer Cell International 2022 22:34

    Content type: Primary research

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  7. Epigenetic reprogramming reportedly has a crucial role in prostate cancer (PCa) progression. RNA modification is a hot topic in epigenetics, and N6-methyladenosine (m6A) accounts for approximately 60% of RNA c...

    Authors: Yongjun Quan, Xiaodong Zhang and Hao Ping

    Citation: Cancer Cell International 2022 22:33

    Content type: Primary research

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  8. Glioblastoma is one of the most common fatal intracranial malignancies. Lysine-specific demethylase 1 (LSD1) reportedly has therapeutic effects on a variety of tumors. This study explored the therapeutic effec...

    Authors: Wei Li, Bai-sheng Huang, Yuan-yuan Xiong, Li-jian Yang and Li-xiang Wu

    Citation: Cancer Cell International 2022 22:32

    Content type: Primary research

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  9. Non-small cell lung cancer (NSCLC) is still one of the diseases with the highest mortality and morbidity, and lung adenocarcinoma (LUAD) accounts for more than half of all NSCLC cases in most countries. miRNA ...

    Authors: Zijian Ma, Ganyi Chen, Yiqian Chen, Zizhang Guo, Hao Chai, Yu Tang, Lin Zheng, Ke Wei, Chunfeng Pan, Zhifei Ma, Yang Xia and Aiping Zhang

    Citation: Cancer Cell International 2022 22:31

    Content type: Primary research

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  10. Raw areca nut (RAN) consumption induces oral, esophageal and gastric cancers, which are significantly associated with the overexpression of pituitary tumor transforming gene 1/securin and chromosomal instabili...

    Authors: Nabamita Boruah, Chongtham Sovachandra Singh, Pooja Swargiary, Hughbert Dkhar and Anupam Chatterjee

    Citation: Cancer Cell International 2022 22:30

    Content type: Primary research

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  11. Liver is the most common metastatic site of colorectal cancer (CRC) and liver metastasis (LM) determines subsequent treatment as well as prognosis of patients, especially in T1 patients. T1 CRC patients with L...

    Authors: Tenghui Han, Jun Zhu, Xiaoping Chen, Rujie Chen, Yu Jiang, Shuai Wang, Dong Xu, Gang Shen, Jianyong Zheng and Chunsheng Xu

    Citation: Cancer Cell International 2022 22:28

    Content type: Primary research

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  12. Circular RNAs (circRNAs) have emerged as vital regulators of the initiation and progression of diverse kinds of human cancers. In this study, we explored the role of hsa_circ_0000231 and its downstream pathway in...

    Authors: Wei Zhang, Bo Wang, Yilin Lin, Yang Yang, Zhen Zhang, Quan Wang, Haoran Zhang, Kewei Jiang, Yingjiang Ye, Shan Wang and Zhanlong Shen

    Citation: Cancer Cell International 2022 22:27

    Content type: Primary research

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  13. Long noncoding RNAs (lncRNAs) play a critical role in innate and adaptive immune responses. Thus, we aimed to identify ideal subtypes for head and neck squamous cell carcinoma (HNSCC) based on immune-related l...

    Authors: Ruoyan Cao, Lin Cui, Jiayu Zhang, Xianyue Ren, Bin Cheng and Juan Xia

    Citation: Cancer Cell International 2022 22:25

    Content type: Primary research

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  14. The Src homology and collagen 4 (SHC4) is an important intracellular adaptor protein that has been shown to play a pro-cancer role in melanoma and glioma. However, the biological function and detailed mechanis...

    Authors: Xin Zhang, Hongwei Zhang, Zhibin Liao, Jiacheng Zhang, Huifang Liang, Weixing Wang, Jia Yu and Keshuai Dong

    Citation: Cancer Cell International 2022 22:24

    Content type: Primary research

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  15. Krüppel‐like factors (KLFs) are zinc finger proteins which participate in transcriptional gene regulation. Although increasing evidence indicate that KLFs are involved in carcinogenesis and progression, its cl...

    Authors: Ke-Yun Zhu, Yao Tian, Ying-Xi Li, Qing-Xiang Meng, Jie Ge, Xu-Chen Cao, Ti Zhang and Yue Yu

    Citation: Cancer Cell International 2022 22:23

    Content type: Primary research

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  16. In recent years, the Fibrinogen to pre-albumin ratio (FPR) has been reported in many studies to be significantly associated with the prognosis of various cancers. This systematic review and meta-analysis aimed...

    Authors: Baibei Li, Huachu Deng, Ziyan Zhou and Bo Tang

    Citation: Cancer Cell International 2022 22:22

    Content type: Review

    Published on:

  17. Molecular markers play an important role in predicting clinical outcomes in pancreatic adenocarcinoma (PAAD) patients. Analysis of the ferroptosis-related genes may provide novel potential targets for the prog...

    Authors: Jihua Yang, XiaoHong Wei, Fang Hu, Wei Dong and Liao Sun

    Citation: Cancer Cell International 2022 22:21

    Content type: Primary research

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  18. The roles of Polypyrimidine tract-binding protein 3 (PTBP3) in regulating lung squamous cell carcinoma (LUSC) cells progression is unclear. The aim of this study was to investigate the role of PTBP3 in LUSC.

    Authors: Yingji Chen, Ying Ji, Suo Liu, Yicai Liu, Wei Feng and Longyu Jin

    Citation: Cancer Cell International 2022 22:19

    Content type: Primary research

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  19. Short-term starvation (STS) has gradually been confirmed as a treatment method that synergistically enhances the effect of chemotherapy on malignant tumours. In clinical applications, there are still some limi...

    Authors: Wang Zhi, Suting Li, Yuting Wan, Fuwen Wu and Li Hong

    Citation: Cancer Cell International 2022 22:18

    Content type: Primary research

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  20. HPV as the main cause of cervical cancer has long been revealed, but the detailed mechanism has not yet been elucidated. The role of testis/cancer antigen in cervical cancer has been revealed. However, there a...

    Authors: Yuanhang Zhu, Chenchen Ren, Li Yang, Zhenan Zhang, Meiyuan Gong and Kebing Chen

    Citation: Cancer Cell International 2022 22:17

    Content type: Primary research

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  21. Nasopharyngeal carcinoma (NPC) is a deadly cancer, mainly presenting in southeast and east Asia. Long noncoding RNAs (lncRNAs) play essential roles in cancer progression. Exosomes are critical for intercellula...

    Authors: Hongchao Yao, Linli Tian, Bingrui Yan, Like Yang and Yushan Li

    Citation: Cancer Cell International 2022 22:16

    Content type: Primary research

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  22. Accumulating evidence has revealed that aberrant microRNA (miRNA) expression can affect the development of chemotherapy drug resistance by modulating the expression of relevant target proteins. Emerging eviden...

    Authors: Yang Zhou, Chunyan Wang, Jinye Ding, Yingying Chen, Yaoqi Sun and Zhongping Cheng

    Citation: Cancer Cell International 2022 22:15

    Content type: Primary research

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  23. Mucin-1 (MUC-1) is a transmembrane glycoprotein, which bears many similarities between dogs and humans. Since the existence of animal models is essential to understand the significant factors involved in breas...

    Authors: Rana Vafaei, Mitra Samadi, Aysooda Hosseinzadeh, Khadijeh Barzaman, MohammadReza Esmailinejad, Zohreh Khaki and Leila Farahmand

    Citation: Cancer Cell International 2022 22:14

    Content type: Review

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  24. N6-methyladenosine (m6A) is a dynamic and reversible internal RNA structure of eukaryotic mRNA. YTH domain family 2 (YTHDF2), an m6A-specific reader YTH domain family, plays fundamental roles in several types ...

    Authors: Peng Xu, Kang Hu, Ping Zhang, Zhi-Gang Sun and Nan Zhang

    Citation: Cancer Cell International 2022 22:13

    Content type: Primary Research

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  25. At present, more than one cell death pathways have been found, one of which is ferroptosis. Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid peroxidation-driven regulated cell de...

    Authors: Qing Nie, Yue Hu, Xiao Yu, Xiao Li and Xuedong Fang

    Citation: Cancer Cell International 2022 22:12

    Content type: Review

    Published on:

  26. N6-methyladenosine (m6A) has emerged as a significant regulator of the progress of various cancers. However, its role in lung adenocarcinoma (LUAD) remains unclear. Here, we explored the biological function and u...

    Authors: Yiming Xu, Dandan Lv, Chao Yan, Hua Su, Xue Zhang, Yangfeng Shi and Kejing Ying

    Citation: Cancer Cell International 2022 22:11

    Content type: Primary research

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  27. Chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) are two common malignant disorders in leukemia. Although potent drugs are emerging, CML and AML may still relapse after the drug treatment is sto...

    Authors: Li-Rong Yang, Zhu-Ying Lin, Qing-Gang Hao, Tian-Tian Li, Yun Zhu, Zhao-Wei Teng and Jun Zhang

    Citation: Cancer Cell International 2022 22:10

    Content type: Primary research

    Published on:

  28. Glioblastoma multiforme (GBM) is a heterogeneous CNS neoplasm which causes significant morbidity and mortality. One reason for the poor prognostic outcome of GBM is attributed to the presence of cancer stem ce...

    Authors: Hany E. Marei, Asmaa Althani, Nahla Afifi, Anwarul Hasan, Thomas Caceci, Armando Felsani, Giuseppe Tringali, Ingrid Cifola, Giacomo Pozzoli and Carlo Cenciarelli

    Citation: Cancer Cell International 2022 22:9

    Content type: Primary research

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  29. In humans, riboflavin must be obtained through intestinal absorption because it cannot be synthesized by the body. SLC52A2 encodes a membrane protein belonging to the riboflavin transporter protein family and ...

    Authors: Lilong Zhang, Man Li, Zhoujun Cui, Dongqi Chai, Yongjun Guan, Chen Chen and Weixing Wang

    Citation: Cancer Cell International 2022 22:8

    Content type: Primary research

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  30. Bladder cancer (BLCA) is one of the most common malignancies worldwide. One of the main reasons for the unsatisfactory management of BLCA is the complex molecular biological mechanism. Annexin A1 (ANXA1), a Ca2+-...

    Authors: Piao Li, Lingling Li, Zhou Li, Shennan Wang, Ruichao Li, Weiheng Zhao, Yanqi Feng, Shanshan Huang, Lu Li, Hong Qiu and Shu Xia

    Citation: Cancer Cell International 2022 22:7

    Content type: Primary research

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  31. Ovarian cancer is the most aggressive gynecological malignancy. Transcriptional regulators impact the tumor phenotype and, consequently, clinical progression and response to therapy. PHD finger protein 20-like...

    Authors: Dulce Rosario Alberto-Aguilar, Verónica Ivonne Hernández-Ramírez, Juan Carlos Osorio-Trujillo, Dolores Gallardo-Rincón, Alfredo Toledo-Leyva and Patricia Talamás-Rohana

    Citation: Cancer Cell International 2022 22:6

    Content type: Primary research

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  32. Alternative splicing (AS) plays important roles in transcriptome and proteome diversity. Its dysregulation has a close affiliation with oncogenic processes. This study aimed to evaluate AS-based biomarkers by ...

    Authors: Boxue He, Cong Wei, Qidong Cai, Pengfei Zhang, Shuai Shi, Xiong Peng, Zhenyu Zhao, Wei Yin, Guangxu Tu, Weilin Peng, Yongguang Tao and Xiang Wang

    Citation: Cancer Cell International 2022 22:5

    Content type: Primary research

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  33. Serine/threonine protein kinase 25 (STK25) plays an important role in regulating glucose and insulin homeostasis and in ectopic lipid accumulation. It directly affects the progression and prognosis of nonalcoh...

    Authors: Yichao Zhang, Junhui Xu, Zhendong Qiu, Yongjun Guan, XiaoYi Zhang, Xin Zhang, Dongqi Chai, Chen Chen, Qinyong Hu and Weixing Wang

    Citation: Cancer Cell International 2022 22:4

    Content type: Primary research

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  34. Recently, immune checkpoint inhibitors (ICIs) therapy has become a promising therapeutic strategy with encouraging therapeutic outcomes due to their durable anti-tumor effects. Though, tumor inherent or acquir...

    Authors: Somayeh Vafaei, Angelina O. Zekiy, Ramadhan Ado Khanamir, Burhan Abdullah Zaman, Arman Ghayourvahdat, Hannaneh Azimizonuzi and Majid Zamani

    Citation: Cancer Cell International 2022 22:2

    Content type: Review

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  35. Ferroptosis is a newly identified type of programmed cell death, which preferentially targets iron-rich cancer cells such as hepatocellular carcinoma (HCC). Ferritin heavy chain (FTH) is a major iron storing n...

    Authors: Wanye Hu, Chaoting Zhou, Qiangan Jing, Yancun Li, Jing Yang, Chen Yang, Luyang Wang, Jiayu Hu, Huanjuan Li, Hairui Wang, Chen Yuan, Yi Zhou, Xueying Ren, Xiangmin Tong, Jing Du and Ying Wang

    Citation: Cancer Cell International 2021 21:709

    Content type: Primary research

    Published on:

  36. Distance metastasis is the leading cause of death for breast cancer patients, and circulating tumor cells (CTCs) play a key role in cancer metastasis. There have been few studies on CTCs at the molecular level...

    Authors: Xuan Li, Hefen Sun, Qiqi Liu, Yang Liu, Yifeng Hou and Wei Jin

    Citation: Cancer Cell International 2021 21:708

    Content type: Primary research

    Published on:

  37. Osteosarcoma is the most common primary bone tumor in children and adolescents. However, some patients with osteosarcoma develop resistance to chemotherapy, leading to a poor clinical prognosis. Hence, effecti...

    Authors: Hong-Bo Li, Jun-Kai Chen, Ze-Xin Su, Qing-Lin Jin, Li-Wen Deng, Gang Huang and Jing-Nan Shen

    Citation: Cancer Cell International 2021 21:706

    Content type: Primary research

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  38. Cancer can be considered as a communication disease between and within cells; nevertheless, there is no effective therapy for the condition, and this disease is typically identified at its late stage. Chemothe...

    Authors: Negar Noorbakhsh, Bentolhoda Hayatmoghadam, Marzieh Jamali, Maryam Golmohammadi and Maria Kavianpour

    Citation: Cancer Cell International 2021 21:705

    Content type: Review

    Published on:

  39. Fasting mimic diet is an effect approach for gastric cancer (GC) treatment. Exploring mechanisms of glucose deprivation-mediated GC suppression is required to develop novel therapeutic regimens. Farnesyltransf...

    Authors: Ruiyang Zhao, Bo Cao, Hanghang Li, Tian Li, Xingming Xu, Hao Cui, Huan Deng and Bo Wei

    Citation: Cancer Cell International 2021 21:704

    Content type: Primary research

    Published on:

  40. The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malign...

    Authors: Hany E. Marei, Asmaa Althani, Nahla Afifi, Anwarul Hasan, Thomas Caceci, Giacomo Pozzoli, Andrea Morrione, Antonio Giordano and Carlo Cenciarelli

    Citation: Cancer Cell International 2021 21:703

    Content type: Review

    Published on:

  41. Post-resistance progress in paclitaxel (PTX) treatment remains a major challenge in tumor treatment. A high dose of PTX was used for cell lines to analyze the changes in molecular expression. The miR-378d was ...

    Authors: Jie Peng, Susu Shi, Juan Yu, Jianli Liu, Haixiang Wei, Haixia Song, Shaoqiang Wang, Zhejie Li, Shujin He, Lei Li, Hongyan Zhang, Zhizhen Yan, Ran Zhao, Yukun Liu, Yanrong Liu, Junjun Li…

    Citation: Cancer Cell International 2021 21:702

    Content type: Primary research

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  42. Epigenetic alterations contribute greatly to metastasis and dissemination in hepatocellular carcinoma (HCC). SMARCC1, as a SWI/SNF chromatin remodeling factor, has been reported to play important roles in many...

    Authors: Xiaopeng Cai, Jiaming Zhou, Jingwen Deng and Zhi Chen

    Citation: Cancer Cell International 2021 21:701

    Content type: Primary research

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  43. Cholangiocarcinoma (CCA) is one of the deadliest cancers of the digestive tract. The prognosis of CCA is poor and the 5-year survival rate is low. Bioinformatic analysis showed that early mitotic inhibitor 2 (...

    Authors: Shuai Zhou, Kang Lin Qu, Jin Ang Li, Shi Lei Chen, Yi Gang Zhang, Chao Zhu, Hao Jin, Yong Wang, Qing Pang and Hui Chun Liu

    Citation: Cancer Cell International 2021 21:699

    Content type: Primary Research

    Published on:

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