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  1. The pathogenesis of multiple myeloma (MM) is not completely known. Uncovering the potential mechanism of MM initiation and progression is essential for identifying novel diagnostic and therapeutic targets. Her...

    Authors: Yan Wang, Quande Lin, Chunge Song, Ruojin Ma and Xiaojie Li

    Citation: Cancer Cell International 2020 20:383

    Content type: Primary research

    Published on:

  2. Pancreatic cancer is a common malignant tumor of the digestive tract. It has a high degree of malignancy and poor prognosis. Finding effective molecular markers has great significance for pancreatic cancer dia...

    Authors: Mu-jing Ke, Lian-dong Ji and Yi-xiong Li

    Citation: Cancer Cell International 2020 20:382

    Content type: Primary research

    Published on:

  3. Chemo-resistance is one of the main obstacles in the treatment of prostate cancer (PCa). Long non-coding RNA small nucleolar RNA host gene 6 (SNHG6) is involved in the chemo-resistance of various tumors. We ai...

    Authors: Chunhui Cao, Guanghai Sun and Chunlin Liu

    Citation: Cancer Cell International 2020 20:381

    Content type: Primary research

    Published on:

  4. Newcastle disease virus (NDV) has shown noticeable oncolytic properties, especially against cervical cancer. However, in order to improve the spread rate and oncotoxicity of the virus, employment of other ther...

    Authors: Seyed Mohammad Miri, Mir Saeed Ebrahimzadeh, Elahe Abdolalipour, Mahsa Yazdi, Hassan Hosseini Ravandi and Amir Ghaemi

    Citation: Cancer Cell International 2020 20:380

    Content type: Primary research

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  5. The roots of Salvia miltiorrhiza are used in traditional Chinese medicine (TCM) and have high medicinal value. Tanshinone IIA (Tan IIA) is the active ingredient of Salvia miltiorrhiza which can inhibit the growth...

    Authors: Zi-Yuan Nie, Ming-Hui Zhao, Bao-Qian Cheng, Rong-Fang Pan, Tian-Rui Wang, Yan Qin and Xue-Jun Zhang

    Citation: Cancer Cell International 2020 20:379

    Content type: Primary research

    Published on:

  6. Growing evidence has demonstrated that glutathione peroxidases (GPXs) family genes play critical roles in onset and progression of human cancer. However, a systematic study regarding expression, diagnostic and...

    Authors: Weiyang Lou, Bisha Ding, Shuqian Wang and Peifen Fu

    Citation: Cancer Cell International 2020 20:378

    Content type: Primary research

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  7. Breast cancer is a common malignancy in women. Among breast cancer types, triple-negative breast cancer (TNBC) tends to affect younger women, is prone to axillary lymph node, lung, and bone metastases; and has...

    Authors: Chengli Lu, Zhiyuan Ma, Xiaoming Cheng, Huichao Wu, Biguang Tuo, Xuemei Liu and Taolang Li

    Citation: Cancer Cell International 2020 20:377

    Content type: Review

    Published on:

  8. Numerous studies have shown that long noncoding RNAs play important roles in human cancer progression. Although zebrafish xenografts have recently become a novel in vivo model for human cancer research, whethe...

    Authors: Wenyi Shen, Juan Pu, Jing Sun, Bing Tan, Wei Wang, Lili Wang, Jianmeng Cheng and Yangsong Zuo

    Citation: Cancer Cell International 2020 20:376

    Content type: Primary research

    Published on:

  9. The aim of this study is to determine whether Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) could be used as a biomarker for the diagnosis and treatment of B cell malignancies. With 4.3% of all new can...

    Authors: Michelle H. Townsend, Zac E. Ence, Taylor P. Cox, John E. Lattin, Weston Burrup, Michael K. Boyer, Stephen R. Piccolo, Richard A. Robison and Kim L. O’Neill

    Citation: Cancer Cell International 2020 20:375

    Content type: Primary research

    Published on:

  10. Glioma is the most primary central nervous system tumor in adults. The 5 year survival rate for glioma patients remains poor, although treatment strategies had improved in the past few decades. The cumulative ...

    Authors: Niya Long, Liangzhao Chu, Jun Jia, Shuo Peng, Yuan Gao, Hua Yang, Yaoming Yang, Yan Zhao and Jian Liu

    Citation: Cancer Cell International 2020 20:374

    Content type: Primary research

    Published on:

  11. Ovarian cancer (OC) is the most malignant tumor in the female reproductive system. About 75% of OC in complete remission of clinical symptoms still develop a recurrence. Therefore, searching for new treatment ...

    Authors: Fangfang Bi, Ying Chen and Qing Yang

    Citation: Cancer Cell International 2020 20:373

    Content type: Primary research

    Published on:

  12. Long non-coding RNAs (LncRNAs) have been increasingly confirmed to be abnormally expressed in human cancer and closely related to tumorigenesis. LncRNA ACTA2-AS1 is abnormally expressed in multiple tumors and ...

    Authors: Lingli Luo, Min Wang, Xianping Li, Can Luo, Shan Tan, Sheng Yin, Lei Liu and Xiaolin Zhu

    Citation: Cancer Cell International 2020 20:372

    Content type: Primary research

    Published on:

  13. Hepatocellular carcinoma (HCC) is the most aggressive and frequently diagnosed malignancy of the liver. Despite aggressive therapy, life expectancy of many patients in these cases is extended by only a few mon...

    Authors: Yi Xiao, Qiang Gong, Wenhong Wang, Fang Liu, Qinghong Kong, Feng Pan, Xiaoke Zhang, Changyan Yu, Shanshan Hu, Fang Fan, Sanhua Li and Yun Liu

    Citation: Cancer Cell International 2020 20:371

    Content type: Primary research

    Published on:

  14. Reversible acetylation of α-tubulin has been implicated in modulating microtuble structures and functions, which may subsequently involve in cellular apoptosis and autophage. But how to trigger apoptosis or au...

    Authors: Qilin Wang and Xiangguo Liu

    Citation: Cancer Cell International 2020 20:369

    Content type: Primary research

    Published on:

  15. T cell receptor gamma locus antisense RNA 1 (TRG-AS1) has been reported to involve in the progression of glioblastoma, however the role and its underlying molecular mechanism in hepatocellular carcinoma (HCC) ...

    Authors: Xuehu Sun, Yeben Qian, Xingyu Wang, Rongge Cao, Jianlin Zhang, Weidong Chen and Maoyong Fang

    Citation: Cancer Cell International 2020 20:367

    Content type: Primary research

    Published on:

  16. Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versu...

    Authors: Zhen-xian Lew, Hui-min Zhou, Yuan-yuan Fang, Zhen Ye, Wa Zhong, Xin-yi Yang, Zhong Yu, Dan-yu Chen, Si-min Luo, Li-fei Chen and Ying Lin

    Citation: Cancer Cell International 2020 20:366

    Content type: Primary research

    Published on:

  17. Mammary Paget’s disease (MPD) is an uncommon cutaneous intraepithelial malignancy with ulceration of the nipple or areola. Its pathogenesis and genomic mutation remain largely unknown and no cell lines are est...

    Authors: Bo Pan, Dongyi Zhao, Yaqian Liu, Na Li, Chen Song, Ning Li, Xuelu Li, Man Li and Zuowei Zhao

    Citation: Cancer Cell International 2020 20:365

    Content type: Primary research

    Published on:

  18. Cisplatin resistance of ovarian yolk sac tumors (oYST) is a clinical challenge due to dismal patient prognosis, even though the disease is extremely rare. We investigated potential association between cisplati...

    Authors: Silvia Schmidtova, Lambert C. J. Dorssers, Katarina Kalavska, Ad J. M. Gillis, J. Wolter Oosterhuis, Hans Stoop, Svetlana Miklikova, Zuzana Kozovska, Monika Burikova, Katarina Gercakova, Erika Durinikova, Michal Chovanec, Michal Mego, Lucia Kucerova and Leendert H. J. Looijenga

    Citation: Cancer Cell International 2020 20:364

    Content type: Primary research

    Published on:

  19. As a new kind of RNA, circular RNA (circRNA) is a endogenous non-coding RNA with circular structure, which has the characteristics of universality, stability, conservatism and specificity. CircRNA can specific...

    Authors: Xiaoqing Zhang, Ning Lu, Li Wang, Yixuan Wang, Minna Li, Ying Zhou, Honglin Yan, Manli Cui, Mingxin Zhang and Lingmin Zhang

    Citation: Cancer Cell International 2020 20:362

    Content type: Review

    Published on:

  20. Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV), known oncoviruses, can be co-present and cooperate in the initiation and/or progression of human carcinomas, including head and neck. Based on this f...

    Authors: Hamda Al-Thawadi, Ishita Gupta, Ayesha Jabeen, Faruk Skenderi, Tahar Aboulkassim, Amber Yasmeen, Mohammed I. Malki, Gerald Batist, Semir Vranic and Ala-Eddin Al Moustafa

    Citation: Cancer Cell International 2020 20:361

    Content type: Primary research

    Published on:

  21. Hepatocellular carcinoma (HCC) is the most common malignant heterogeneous disease in primary liver tumors. Circular RNA hsa_circ_0000517 (hsa_circ_0000517) is connected with HCC prognosis. Nevertheless, there ...

    Authors: Shuwei He, Zhengwu Guo, Qian Kang, Xu Wang and Xingmin Han

    Citation: Cancer Cell International 2020 20:360

    Content type: Primary research

    Published on:

  22. Cervical cancer (CC) is the 4th most common cancer-related death in gynecological cancer worldwide. It has been reported that many lncRNAs contribute to oncogenesis although the fundamental mechanisms are basi...

    Authors: Xinghua Shi, Jinzhi Huo, Xingping Gao, Hua Cai and Weipei Zhu

    Citation: Cancer Cell International 2020 20:358

    Content type: Primary research

    Published on:

  23. Increasing researches have reported that circular RNA UBAP2 (circUBAP2) may be a potential prognosis biomarker and participate in the development of several cancers; however, the role of circUBAP2 in cervical ...

    Authors: Lingli Meng, Xiupeng Jia, Wenying Yu, Chunnian Wang, Jie Chen and Fenglei Liu

    Citation: Cancer Cell International 2020 20:357

    Content type: Primary research

    Published on:

  24. EPB41L1 gene (erythrocyte membrane protein band 4.1 like 1) encodes the protein 4.1N, a member of 4.1 family, playing a vital role in cell adhesion and migration, which is associated with the malignant progres...

    Authors: Taotao Liang, Siyao Sang, Qi Shao, Chen Chen, Zhichao Deng, Ting Wang and Qiaozhen Kang

    Citation: Cancer Cell International 2020 20:356

    Content type: Primary research

    Published on:

  25. Esophageal cancer is one of the most common cancers worldwide with poor prognosis and high mortality. The transcription factor SNAI1, encoding Snail1, is important for metastatic progression in esophageal cancer ...

    Authors: Gang Li, Hong-wei Qi, He-gui Dong, Ping Bai, Ming Sun and Hai-yan Liu

    Citation: Cancer Cell International 2020 20:355

    Content type: Primary research

    Published on:

  26. Cervical cancer (CC) is one of the most common female malignancies over the world. Microtubule-associated protein 7 (MAP7) belongs to the family of microtubule-associated proteins (MAPs) which involve in micro...

    Authors: Ning Tang, Dan Lyu, Jian-Fang Chang, Zhi-Tao Liu, Yan Zhang and Hai-Ping Liu

    Citation: Cancer Cell International 2020 20:354

    Content type: Primary research

    Published on:

  27. anaplastic thyroid cancer (ATC) is one of the most lethal and aggressive cancers. Evidence has shown that the tumorigenesis of ATC is a multistep process involving the accumulation of genetic and epigenetic ch...

    Authors: Hilda Samimi, Sayed Mahmoud Sajjadi-Jazi, Soroush Seifirad, Rasha Atlasi, Habibollah Mahmoodzadeh, Mohammad Ali Faghihi and Vahid Haghpanah

    Citation: Cancer Cell International 2020 20:352

    Content type: Review

    Published on:

  28. Gastric cancer is a serious malignant tumor associated with aberrant circular RNAs (circRNAs) expression. In this study, we aim to investigate the role and the underlying mechanism of circ_0000190, a circRNA i...

    Authors: Gui-Jun Wang, Tian-Yu Yu, Yan-Rong Li, Yang-Jun Liu and Bei-Bei Deng

    Citation: Cancer Cell International 2020 20:351

    Content type: Primary research

    Published on:

  29. Genetic and epigenetic alterations have been indicated to be closely correlated with the carcinogenesis, DNA methylation is one of most frequently occurring molecular behavior that take place early during this...

    Authors: Qixin Lian, Bo Wang, Lijun Fan, Junqiang Sun, Guilai Wang and Jidong Zhang

    Citation: Cancer Cell International 2020 20:349

    Content type: Primary research

    Published on:

  30. Long non-coding RNAs (lncRNAs) are a class of endogenous non-coding RNAs of longer than 200 bp that play crucial roles in cancer biology. Here, we assessed the tumorigenic properties of a long noncoding RNA, M...

    Authors: Zhi Zhou, Shan Zhang and Yaqiong Xiong

    Citation: Cancer Cell International 2020 20:348

    Content type: Primary research

    Published on:

  31. Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is dysregulated and acts as a biological and pharmacological role in human cancers or non-cancers. ALKBH5 plays a dual role in various cancers...

    Authors: Jinyan Wang, Jinqiu Wang, Quan Gu, Yajun Ma, Yan Yang, Jing Zhu and Quan’an Zhang

    Citation: Cancer Cell International 2020 20:347

    Content type: Review

    Published on:

  32. Colorectal cancer (CRC) is one of the most common digestive malignant tumors in the world. Ubiquitin-specific peptidase 18 (USP18) plays a regulatory role in tumorigenesis, and abnormal expression of Snail1 is...

    Authors: Fakun Huang, Chengying Zheng, Longkai Huang, Changqing Lin and Jiaxing Wang

    Citation: Cancer Cell International 2020 20:346

    Content type: Primary research

    Published on:

  33. Meningiomas are the second most common primary tumors of the central nervous system. However, there is a paucity of data on meningioma biology due to the lack of suitable preclinical in vitro and in vivo model...

    Authors: Eunhye Kim, Mirae Kim, Kyungha So, Young Seok Park, Chang Gok Woo and Sang-Hwan Hyun

    Citation: Cancer Cell International 2020 20:345

    Content type: Primary research

    Published on:

  34. Concurrent chemoradiotherapy is the common first-line treatment for patients with advanced cervical cancer. However, radioresistance remains a major clinical challenge, which results in recurrence and poor sur...

    Authors: Shan-Shan Yang, De-Yang Yu, Yu-Ting Du, Le Wang, Lina Gu, Yun-Yan Zhang and Min Xiao

    Citation: Cancer Cell International 2020 20:344

    Content type: Primary research

    Published on:

  35. Long non-coding RNAs (lncRNAs) play significant roles in tumorigenesis and can contribute to identification of novel therapeutic targets for cancers. This paper was aimed at exploring the role of CTBP1 diverge...

    Authors: Shanshan Yang, Feng Shi, Yuting Du, Zhao Wang, Yue Feng, Jiayu Song, Yunduo Liu and Min Xiao

    Citation: Cancer Cell International 2020 20:343

    Content type: Primary research

    Published on:

  36. Aberrant methylation and miRNA-target-gene regulation function as important mechanisms for gene inactivation in colon carcinogenesis. Although a serious of molecular events (such as aberrant alterations of gen...

    Authors: Jiaxin Liu, Zhao Liu, Xiaozhi Zhang, Yanli Yan, Shuai Shao, Demao Yao and Tuotuo Gong

    Citation: Cancer Cell International 2020 20:342

    Content type: Primary research

    Published on:

  37. Cervical cancer (CC) is the second leading cause of cancer deaths in women worldwide, still lacking effective biomarkers and therapies for diagnosis and treatment. CircRNAs are a class of endogenous RNAs that ...

    Authors: Shuaisai Zhang, Zhengli Chen, Jinxue Sun, Na An and Qinghua Xi

    Citation: Cancer Cell International 2020 20:287

    Content type: Primary research

    Published on:

  38. As one of the most lethal cancers, pancreatic cancer has been characterized by abundant supportive tumor-stromal cell microenvironment. Although the advent of tumor-targeted immune checkpoint blockers has brou...

    Authors: Tong Li, Qiaofei Liu, Ronghua Zhang, Quan Liao and Yupei Zhao

    Citation: Cancer Cell International 2020 20:341

    Content type: Primary research

    Published on:

  39. Long non-coding RNAs (lncRNAs) have been certified to be involved in the occurrence and growth of diverse cancers, including CRC. The purpose of the research was to explore the effects of lncRNA KCNQ1 overlapp...

    Authors: Xing Liu, Yexiang Zhang, Yan Wang, Chao Bian and Fengji Wang

    Citation: Cancer Cell International 2020 20:340

    Content type: Primary research

    Published on:

  40. GATA binding protein 3 (GATA3) and miR-29b are related to colorectal cancer (CRC). The current study explored the regulatory relationship between GATA3 and miR-29b, and the mechanism of the two in the drug res...

    Authors: Wei Wang, Mei Wang, Jing Xu, Fei Long and Xianbao Zhan

    Citation: Cancer Cell International 2020 20:339

    Content type: Primary research

    Published on:

  41. Cell autophagy has been proposed to be involved in drug resistance therapy. However, how the long non-coding RNA (lncRNA) reduces risks of drug resistance in renal cancer (RC) cells needs a thorough inquiry. T...

    Authors: Dechao Li, Changfu Li, Yongsheng Chen, Lichen Teng, Yan Cao, Wentao Wang, Hongxin Pan, Yongpeng Xu and Dan Yang

    Citation: Cancer Cell International 2020 20:338

    Content type: Primary research

    Published on:

  42. Glioblastoma multiforme (GBM) is the most common and lethal type of primary brain tumor. More than half of GBMs contain mutation(s) of PTEN/PI3K/AKT, making inhibitors targeting the PI3K pathway very attractiv...

    Authors: Zhen Chen, Chao Chen, Tingting Zhou, Chao Duan, Qianqian Wang, Xiaohui Zhou, Xia Zhang, Fangrong Wu, Yunfen Hua and Fan Lin

    Citation: Cancer Cell International 2020 20:337

    Content type: Primary research

    Published on:

  43. Accumulating data suggested that circular RNAs (circRNAs) played important roles in the development of human cancer. However, the potential mechanism of circRNAs in ovarian cancer remains unclear.

    Authors: Chunli Lin, Xiaofeng Xu, Qiumin Yang, Lu Liang and Shulin Qiao

    Citation: Cancer Cell International 2020 20:336

    Content type: Primary research

    Published on:

  44. Antisense non-coding RNA in the INK4 locus (ANRIL) is of great importance in cell biological behaviors, and ANRIL functions in many kinds of cancers including leukemia. However, the mechanism of ANRIL in the p...

    Authors: Gang Li, Lan Gao, Jing Zhao, Dejun Liu, Hui Li and Min Hu

    Citation: Cancer Cell International 2020 20:335

    Content type: Primary research

    Published on:

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