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  1. Novel chemotherapeutic drugs with good anti-tumor activity are of pressing need for bladder cancer treatment. In this study, plumbagin (PL), a natural plant-derived drug extracted from Chinese herbals, was ide...

    Authors: Renjie Zhang, Zijian Wang, Wenjie You, Fengfang Zhou, Zicheng Guo, Kaiyu Qian, Yu Xiao and Xinghuan Wang

    Citation: Cancer Cell International 2020 20:520

    Content type: Primary research

    Published on:

  2. Cytotoxic T-lymphocyte associated protein 4 (CTLA4) inhibitors have been shown to significantly prolong the overall survival (OS) in a wide range of cancers. However, its application in clear cell renal cell c...

    Authors: Shiyi Liu, Feiyan Wang, Wei Tan, Li Zhang, Fangfang Dai, Yanqing Wang, Yaqi Fan, Mengqin Yuan, Dongyong Yang, Yajing Zheng, Zhimin Deng, Yeqiang Liu and Yanxiang Cheng

    Citation: Cancer Cell International 2020 20:519

    Content type: Primary research

    Published on:

  3. Glioma is the most frequent and lethal primary brain malignancy. Amounting evidence has highlighted the importance of exosomal microRNAs (miRNAs or miRs) in this malignancy. This study aimed to investigate the...

    Authors: Meng Wang, Yi Zhao, Zhi-Yun Yu, Ren-De Zhang, Shu-Ang Li, Peng Zhang, Ti-Kun Shan, Xue-You Liu, Ze-Ming Wang, Pei-Chao Zhao and Hong-Wei Sun

    Citation: Cancer Cell International 2020 20:518

    Content type: Primary research

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  4. Ovarian cancer (OC) is a common gynecological cancer and characterized by high metastatic potential. MicroRNAs (miRNAs, miRs) have the promise to be harnessed as prognostic and therapeutic biomarkers for OC. H...

    Authors: Yang Gu and Shulan Zhang

    Citation: Cancer Cell International 2020 20:517

    Content type: Primary research

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  5. The upregulation of ADAM17 has been reported to be associated with invasion and metastasis in various tumors, however the molecular mechanism of ADAM17 in the progression of hepatocellular carcinoma (HCC) rema...

    Authors: Yuqi Xiang, Liyu Liu, Ying Wang, Bo Li, Jinwu Peng and Deyun Feng

    Citation: Cancer Cell International 2020 20:516

    Content type: Primary research

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  6. CD137 is a target for tumor immunotherapy. However, the role of CD137 in gastric cancer (GC), especially in inducing GC cell apoptosis, has not been studied.

    Authors: Ben-Shun Hu, Tian Tang, Jun-Li Jia, Bi-Chen Xie, Tie-Long Wu, Ying-Yue Sheng, Yu-Zheng Xue and Hua-Min Tang

    Citation: Cancer Cell International 2020 20:513

    Content type: Primary research

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  7. Prostate cancer (PCa) is a kind of malignancy occurring in the prostate gland. Substantial researches have proved the major role of long noncoding RNAs (lncRNAs) in PCa. However, the role of long intergenic no...

    Authors: Enhui Ma, Qianqian Wang, Jinhua Li, Xinqi Zhang, Zhenjia Guo and Xiaofeng Yang

    Citation: Cancer Cell International 2020 20:515

    Content type: Primary research

    Published on:

  8. Long noncoding RNAs (lncRNAs) are involved in the tumorigenesis and progression of human cancers, including renal cell carcinoma (RCC). Small nucleolar RNA host gene 4 (SNHG4) is reported to play an essential ...

    Authors: Jie Wu, Tingting Liu, Lulu Sun, Shaojin Zhang and Gang Dong

    Citation: Cancer Cell International 2020 20:514

    Content type: Primary research

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  9. The prognosis of colon cancer is poor for metastasis, while the mechanism, especially adipocytes related, is not yet clear. The purpose of this study is to determine the effects of fatty acid binding protein 4...

    Authors: Wenying Tian, Wenjia Zhang, Yan Zhang, Tianyue Zhu, Yuting Hua, Hui Li, Qinglin Zhang and Min Xia

    Citation: Cancer Cell International 2020 20:512

    Content type: Primary research

    Published on:

  10. Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present ...

    Authors: Zhiyan Ruan, Hongling Deng, Minhua Liang, Zhe Xu, Manxiang Lai, Hong Ren, Xiangliang Deng and Xinguo Su

    Citation: Cancer Cell International 2020 20:511

    Content type: Primary research

    Published on:

  11. Due to the high morbidity and poor clinical outcomes, early predictive and prognostic biomarker identification is desiderated in colorectal cancer (CRC). As a homologue of the Deleted in Colorectal Cancer (DCC...

    Authors: Meng Zhang, Zhou Zhou, Xue-kai Pan, Yun-jiao Zhou, Hai-ou Li, Pei-shan Qiu, Meng-na Zhang, Ru-yi Peng, Hai-zhou Wang, Lan Liu, Jing Liu and Qiu Zhao

    Citation: Cancer Cell International 2020 20:510

    Content type: Primary research

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  12. Plakophilins (PKPs) are widely involved in gene transcription, translation, and signal transduction, playing a crucial role in tumorigenesis and progression. However, the function and potential mechanism of PK...

    Authors: Lingling Gao, Xiao Li, Qian Guo, Xin Nie, Yingying Hao, Qing Liu, Juanjuan Liu, Liancheng Zhu, Limei Yan and Bei Lin

    Citation: Cancer Cell International 2020 20:509

    Content type: Primary research

    Published on:

  13. As an aggressive subtype of breast cancer with a high risk of recurrence, triple-negative breast cancer (TNBC) lacks available treatment targets. LncRNA MIR100HG promotes cell proliferation in TNBC. However, f...

    Authors: Fei-Yu Chen, Zhi-Yang Zhou, Ke-Jing Zhang, Jian Pang and Shou-Man Wang

    Citation: Cancer Cell International 2020 20:508

    Content type: Primary research

    Published on:

  14. Increasing evidence has indicated that long noncoding RNAs (lncRNAs) play various important roles in the development of cancers. The widespread applications of ribosome profiling and ribosome nascent chain com...

    Authors: Mujie Ye, Jingjing Zhang, Meng Wei, Baihui Liu and Kuiran Dong

    Citation: Cancer Cell International 2020 20:506

    Content type: Review

    Published on:

  15. Cancer stem cells (CSCs) play an important role in tumor invasion and metastasis. CD44 is the most commonly used marker of CSCs, with the potential to act as a determinant against the invasion and migration of...

    Authors: Xiaodong Yan, Dali Han, Zhiqiang Chen, Chao Han, Wei Dong, Li Han, Lei Zou, Jianbo Zhang, Yan Liu and Jie Chai

    Citation: Cancer Cell International 2020 20:505

    Content type: Primary research

    Published on:

  16. LOXL1-AS1 is a long non-coding RNA (lncRNA) that plays crucial roles in various cancers. However, the functional role of LOXL1-AS1 in laryngocarcinoma remains unclear. Thus we planned to probe into the functio...

    Authors: Guijun He, Wenfeng Yao, Liang Li, Yang Wu, Guojian Feng and Li Chen

    Citation: Cancer Cell International 2020 20:504

    Content type: Primary research

    Published on:

  17. Tumors display a high rate of glucose metabolism and the SLC2A (also known as GLUT) gene family may be central regulators of cellular glucose uptake. However, roles of SLC2A family in mechanism of metabolite c...

    Authors: Xingxing Yao, Zhanke He, Caolitao Qin, Xiangqian Deng, Lan Bai, Guoxin Li and Jiaolong Shi

    Citation: Cancer Cell International 2020 20:503

    Content type: Primary research

    Published on:

  18. Non-small cell lung cancer (NSCLC) includes lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). MicroRNA (miRNA) plays an important role in the regulation of post-transcriptional gene expressio...

    Authors: Xinyue Du, Shuangmiao Wang, Xingyan Liu, Tao He, Xiangui Lin, Simin Wu, Dan Wang, Jiao Li, Wenhua Huang and Huiling Yang

    Citation: Cancer Cell International 2020 20:502

    Content type: Primary research

    Published on:

  19. Triple-negative breast cancer (TNBC) is a highly aggressive malignancy that lacks sensitivity to chemotherapy, endocrine therapy or targeted therapy. CDK4/6 inhibitors, combined with endocrine therapy, have be...

    Authors: Yajing Huang, Hao Wu and Xingrui Li

    Citation: Cancer Cell International 2020 20:501

    Content type: Primary research

    Published on:

  20. Cervical cancer is the second leading cause of death in women 20–39 years old. Because coverage for cervical cancer screening is low, and the vaccination rate of human papillomavirus (HPV) is poor in some coun...

    Authors: Chang Yang, Zhao-Cong Zhang, Tian -Bo Liu, Ye Xu, Bai-Rong Xia and Ge Lou

    Citation: Cancer Cell International 2020 20:500

    Content type: Primary research

    Published on:

  21. Several studies have reported that the systemic immune-inflammation index (SII) is associated with the prognosis of patients with urologic cancers (UCs). The aim of this study was to systematically evaluate th...

    Authors: Yilong Huang, Yunfeng Gao, Yushen Wu and Huapeng Lin

    Citation: Cancer Cell International 2020 20:499

    Content type: Review

    Published on:

  22. Despite improvements in nasopharyngeal carcinoma (NPC) treatment, patients with recurrence and metastasis still have a poor prognosis. Thus, the identification of novel biomarkers is urgently needed to predict...

    Authors: Donglan Huang, Qianqian Liu, Weijun Zhang, Chunyue Huang, Ronghui Zheng, Guofeng Xie, Hongmei Wang, Baochang Jia, Jianjun Shi, Yawei Yuan and Min Deng

    Citation: Cancer Cell International 2020 20:498

    Content type: Primary research

    Published on:

  23. Long noncoding RNAs (LncRNAs) have been reported to critically regulate gastric cancer (GC). Recently, it was reported that LBX2 antisense RNA 1 (LBX2-AS1) is abnormally expressed in GC. However, the role of L...

    Authors: LiPan Peng, ZeZhong Chen, GuangChuan Wang, ShuBo Tian, Shuai Kong, Tao Xu, XiaoHua An and YueZhi Chen

    Citation: Cancer Cell International 2020 20:497

    Content type: Primary research

    Published on:

  24. Accumulating evidence has emerged revealing that noncoding RNAs (ncRNAs) play essential roles in the occurrence and development of hepatocellular carcinoma (HCC). However, the complicated regulatory interactio...

    Authors: Gang Xu, Wei-Yu Xu, Yao Xiao, Bao Jin, Shun-Da Du, Yi-lei Mao and Zhong-Tao Zhang

    Citation: Cancer Cell International 2020 20:496

    Content type: Review

    Published on:

  25. Myeloid-derived suppressor cells (MDSCs) are known suppressors of antitumor immunity and contribute to immunosuppressive microenvironment during tumor development including lung cancer. Accumulating evidence s...

    Authors: Guangping Meng, Jinying Wei, Yanjun Wang, Danhua Qu and Jie Zhang

    Citation: Cancer Cell International 2020 20:495

    Content type: Primary research

    Published on:

  26. Colorectal cancer (CRC) is one of the most common cancers worldwide. Circular RNAs (circRNAs), a novel class of non-coding RNAs, have been confirmed to be key regulators of many diseases. With many scholars de...

    Authors: Yahang Liang, Jingbo Shi, Qingsi He, Guorui Sun, Lei Gao, Jianhong Ye, Xiaolong Tang and Hui Qu

    Citation: Cancer Cell International 2020 20:494

    Content type: Primary research

    Published on:

  27. Pancreatic cancer (PC) is one of the most common cancers and the leading cause of cancer-related death worldwide. Exploring novel predictive biomarkers for PC patients’ prognosis is in urgent need.

    Authors: Hongkai Zhuang, Shanzhou Huang, Zixuan Zhou, Zuyi Ma, Zedan Zhang, Chuanzhao Zhang and Baohua Hou

    Citation: Cancer Cell International 2020 20:493

    Content type: Primary research

    Published on:

  28. The NF1 gene encodes neurofibromin, which is one of the primary negative regulatory factors of the Ras protein. Neurofibromin stimulates the GTPase activity of Ras to convert it from an active GTP-bound form to i...

    Authors: Junyan Tao, Dantong Sun, Lina Dong, Hua Zhu and Helei Hou

    Citation: Cancer Cell International 2020 20:492

    Content type: Review

    Published on:

  29. MiR-924 has been reported to be a tumor suppressor in hepatocellular carcinoma. However, the functions and mechanisms of miR-924 in non-small cell lung cancer (NSCLC) remain unclear.

    Authors: Huaishi Wang, Xi Chen, Baishuang Yang, Zhi Xia and Qiong Chen

    Citation: Cancer Cell International 2020 20:491

    Content type: Primary research

    Published on:

  30. Endometrial carcinoma (EC) is one of the three major malignant tumors of the female reproductive system. In recent years, the incidence and mortality rate of EC have increased. B-cell translocation gene 1 (BTG...

    Authors: Yibing Li, Jianing Huo, Junjian He, Yunzheng Zhang and Xiaoxin Ma

    Citation: Cancer Cell International 2020 20:490

    Content type: Primary research

    Published on:

  31. Cancers may be treated by selective targeting of the genes vital for their survival. A number of attempts have led to discovery of several genes essential for surviving of tumor cells of different types. In th...

    Authors: Irina A. Krivosheeva, Alexandra Yu. Filatova, Sergei A. Moshkovskii, Ancha V. Baranova and Mikhail Yu. Skoblov

    Citation: Cancer Cell International 2020 20:488

    Content type: Primary research

    Published on:

  32. Interleukin-35 (IL-35) has been reported to play an important role in the progression of cancers. The role of IL-35 in prostate cancer (PCA) is not well understood. In this study, we investigated the effects o...

    Authors: Jialin Zhu, Yan Wang, Dai Li, Haonan Zhang, Zhi Guo and Xueling Yang

    Citation: Cancer Cell International 2020 20:487

    Content type: Primary research

    Published on:

  33. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiaonian Zhu, Wei Luo, Chunhua Bei, Juan Kong, Shidong Zhang, Yuanyuan Fu, Di Li and Shengkui Tan

    Citation: Cancer Cell International 2020 20:486

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2019 19:340

  34. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-020-01586-0.

    Authors: Yu Fu, Limin Cai, Xuexue Lei and Dunwei Wang

    Citation: Cancer Cell International 2020 20:485

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2019 19:338

  35. Recently, it has been demonstrated that circular RNA (circRNA) contributes to the production and progression in human cancer. However, the specific function and underlying mechanism of circ_0028171 in osteosar...

    Authors: Feng Pan, Jun Zhang, Benseng Tang, Li Jing, Bing Qiu and Zhengang Zha

    Citation: Cancer Cell International 2020 20:484

    Content type: Primary research

    Published on:

  36. Glucose 6-phosphate dehydrogenase (G6PD) serves key roles in cancer cell metabolic reprogramming, and has been reported to be involved in certain carcinogenesis. Previous results from our laboratory demonstrat...

    Authors: Qiao Zhang, Zhe Yang, Yueli Ni, Honggang Bai, Qiaoqiao Han, Zihan Yi, Xiaojia Yi, Yannick Luther Agbana, Yingmin Kuang and Yuechun Zhu

    Citation: Cancer Cell International 2020 20:483

    Content type: Primary research

    Published on:

  37. We aim to explore association between copy number alteration (CNA) and sensitivity to common tyrosine kinase inhibitors (TKIs) used in clear-cell renal cell carcinoma (ccRCC) treatment.

    Authors: Liang Wang, Yuqing Li, Yinfeng Lyu, Hui Wen and Chenchen Feng

    Citation: Cancer Cell International 2020 20:482

    Content type: Primary research

    Published on:

  38. Circular RNAs (circRNAs) are important regulators in the pathogenesis of diseases and affects the occurrence and development of diseases. However, the role of circRNAs in osteosarcoma (OS) has not been fully e...

    Authors: Zhisheng Long, Feipeng Gong, Yuxu Li, Zhiqiang Fan and Jingtang Li

    Citation: Cancer Cell International 2020 20:481

    Content type: Primary research

    Published on:

  39. Chemoresistance reduces the 5-year survival rate of endometrial cancer patient, which is the current major obstacle for cancer therapy. Increasing evidence state that Nrf2 contributes to chemoresistance in sev...

    Authors: Hong Liao, Dan Zhu, Mingzhu Bai, Huifen Chen, Shihuan Yan, Jing Yu, Huiting Zhu, Wenxin Zheng and Guorong Fan

    Citation: Cancer Cell International 2020 20:480

    Content type: Primary research

    Published on:

  40. Luminal subtype is the most common subgroup of breast cancer (BC), accounting for more than 70% of this cancer. Long non-coding RNAs (lncRNAs) are a group of RNAs which play critical roles in diverse cellular ...

    Authors: Sepideh Mehrpour Layeghi, Maedeh Arabpour, Rezvan Esmaeili, Mohammad Mehdi Naghizadeh, Javad Tavakkoly Bazzaz and Abbas Shakoori

    Citation: Cancer Cell International 2020 20:478

    Content type: Primary research

    Published on:

  41. Exploring novel and sensitive targets is urgent due to the high morbidity of endometrial cancer (EC). The purpose of our study was to explore the transcription factors and immune-related genes in EC and furthe...

    Authors: Yiru Wang, Yunduo Liu, Yue Guan, Hao Li, Yuan Liu, Mengjun Zhang, Ping Cui, Dan Kong, Xiuwei Chen and Hang Yin

    Citation: Cancer Cell International 2020 20:477

    Content type: Primary research

    Published on:

  42. Compelling evidences reported the role of microRNAs (miRNAs) in ovarian cancer. However, little was known regarding the molecular mechanism of miR-367 in ovarian cancer. This study intended to investigate the ...

    Authors: Qingling Zheng, Xin Dai, Wei Fang, Yan Zheng, Jin Zhang, Yanxiang Liu and Donghua Gu

    Citation: Cancer Cell International 2020 20:476

    Content type: Primary research

    Published on:

  43. Colorectal cancer ranks among the most lethal diseases worldwide. Although much progress has been made in research and treatment of colorectal cancer in recent years, the underlying mechanisms related to migra...

    Authors: Weifeng Xu, Beibei Chen, Dianshan Ke and Xiaobing Chen

    Citation: Cancer Cell International 2020 20:475

    Content type: Primary research

    Published on:

  44. Recurrence remains a major obstacle to long-term survival of laryngeal squamous cell carcinoma (LSCC). We conducted a genome-wide integrated analysis of methylation and the transcriptome to establish methylati...

    Authors: Jie Cui, Liping Wang, Waisheng Zhong, Zhen Chen, Jie Chen, Hong Yang and Genglong Liu

    Citation: Cancer Cell International 2020 20:472

    Content type: Primary research

    Published on:

  45. MicroRNAs (miRNAs) are important regulators for cancer cell proliferation. miR-585 has been shown to inhibit the proliferation of several types of cancer, however, little is known about its role in human gliom...

    Authors: Wangsheng Chen, Lan Hong, Changlong Hou, Yibin Wang, Fei Wang and Jianhua Zhang

    Citation: Cancer Cell International 2020 20:469

    Content type: Primary research

    Published on:

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