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Cancer Cell International


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  1. Content type: Primary Research

    The abnormal expression of non-coding RNAs (ncRNAs), such as microRNAs and long ncRNAs, often contribute to the development of cancers. miR-200c functions as a tumour suppressor that impacts the growth of blad...

    Authors: Ran Xu, Xuan Zhu, Fangzhi Chen, Changkun Huang, Kai Ai, Hongtao Wu, Lei Zhang and Xiaokun Zhao

    Citation: Cancer Cell International 2018 18:41

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  2. Content type: Primary Research

    Despite new progress of chemotherapy in multiple myeloma (MM) clinical treatment, MM is still a refractory disease and new technology is needed to improve the outcomes and prolong the survival. Cold atmospheri...

    Authors: Dehui Xu, Yujing Xu, Ning Ning, Qingjie Cui, Zhijie Liu, Xiaohua Wang, Dingxin Liu, Hailan Chen and Michael G. Kong

    Citation: Cancer Cell International 2018 18:42

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  3. Content type: Primary Research

    Low expression of E2F3a and caspase 8 associated protein 2 (CASP8AP2) are associated with poor prognosis of childhood acute lymphoblastic leukemia (ALL).

    Authors: Fei-Fei Liu, Kai-Ling Wang, Li-Ping Deng, Xiao Liu, Min-yuan Wu, Tian-You Wang, Lei Cui and Zhi-Gang Li

    Citation: Cancer Cell International 2018 18:40

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  4. Content type: Primary Research

    MicroRNA-21 (miR-21) was previously reported being dysregulated in many kinds of cancer including esophageal squamous cell carcinoma (ESCC). In the present study, we aimed to investigate the role of miR-21 in ...

    Authors: Fang Li, Jia-Hua Lv, Long Liang, Jun-chao Wang, Chu-Rong Li, Lei Sun and Tao Li

    Citation: Cancer Cell International 2018 18:39

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  5. Content type: Primary Research

    Esophageal squamous cell carcinoma (ESCC) is one of the prevalent and deadly cancers worldwide, especially in China. Considering the poor prognosis of ESCC, the aim of this study is to dissect the effects of l...

    Authors: Bin Liu, Chun-Feng Pan, Guo-Liang Yao, Ke Wei, Yang Xia and Yi-Jiang Chen

    Citation: Cancer Cell International 2018 18:38

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  6. Content type: Primary Research

    MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that play important roles in multiple biological processes. Here, we show that miRNAs play an important function in the down-regulation of FAS expressio...

    Authors: Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki and Hiroshi Tsumura

    Citation: Cancer Cell International 2018 18:37

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  7. Content type: Primary Research

    Rab11 family-interacting protein 2 (Rab11-FIP2) can interact with MYO5B and plays an important role in regulating plasma membrane recycling. However, little is known about the clinical significance of DUSP2 in...

    Authors: Wenjie Dong and Xinai Wu

    Citation: Cancer Cell International 2018 18:35

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  8. Content type: Review

    The aberrant expression of long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) has been demonstrated to be involved in the tumourigenesis and the development of various cancers. Therefore, we ...

    Authors: Huihui Mao, Kai Wang, Yuehua Feng, Jun Zhang, Lili Pan, Yuxia Zhan, Haijun Sheng and Guanghua Luo

    Citation: Cancer Cell International 2018 18:34

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  9. Content type: Primary Research

    Apoptosis plays an important role in the development and homeostasis of multicellular organisms and its deregulation may result in many serious diseases, including cancer. Now it is clear that some oncogenic m...

    Authors: Andrea Vazanova, Jana Jurecekova, Tomas Balharek, Juraj Marcinek, Jan Stasko, Anton Dzian, Lukas Plank, Pavol Zubor, Peter Racay and Jozef Hatok

    Citation: Cancer Cell International 2018 18:33

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  10. Content type: Review

    Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), and is frequently accompanied by the genetic features of von Hippel–Lindau (VHL) loss. VHL loss increases the e...

    Authors: Yongchang Lai, Zhijian Zhao, Tao Zeng, Xiongfa Liang, Dong Chen, Xiaolu Duan, Guohua Zeng and Wenqi Wu

    Citation: Cancer Cell International 2018 18:31

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  11. Content type: Primary research

    Integrins play a critical role in carcinogenesis. Integrin β1 localization is regulated by the guanosine-5′-triphosphate hydrolase Rab25 and integrin β1 levels are elevated in the serum of colon cancer patient...

    Authors: Kyung Sook Hong, Eun-Young Jeon, Soon Sup Chung, Kwang Ho Kim and Ryung-Ah Lee

    Citation: Cancer Cell International 2018 18:32

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  12. Content type: Primary Research

    Store-operated Ca2+ entry (SOCE) has been implicated in the migration of some cancer cell lines. The canonical SOCE is defined as the Ca2+ entry that occurs in response to near-maximal depletion of Ca2+ within th...

    Authors: Priyodarshan Goswamee, Tamar Pounardjian and David R. Giovannucci

    Citation: Cancer Cell International 2018 18:30

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  13. Content type: Primary Research

    New drugs for adrenocortical carcinoma (ACC) are needed because most patients undergo rapid disease progression despite surgery and adjuvant therapy with mitotane. In this study, we aimed to investigate the in...

    Authors: Elaine Silveira, Isadora Pontes Cavalcante, Jean Lucas Kremer, Pedro Omori Ribeiro de Mendonça and Claudimara Ferini Pacicco Lotfi

    Citation: Cancer Cell International 2018 18:29

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  14. Content type: Primary Research

    CD44 encoded by a single gene is a cell surface transmembrane glycoprotein. Exon 2 is one of the important exons to bind CD44 protein to hyaluronan. Experimental evidences show that hyaluronan–CD44 interaction...

    Authors: Rezvan Esmaeili, Nasrin Abdoli, Fatemeh Yadegari, Mohamadreza Neishaboury, Leila Farahmand, Ahmad Kaviani and Keivan Majidzadeh-A

    Citation: Cancer Cell International 2018 18:28

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  15. Content type: Primary Research

    Lung cancer is a malignant tumor with the highest incidence and mortality around the world. Recent advances in RNA sequencing technology have enabled insights into long non-coding RNAs (lncRNAs), a previously ...

    Authors: Xuehai Wang, Gang Li, Qingsong Luo, Jiayong Xie and Chongzhi Gan

    Citation: Cancer Cell International 2018 18:27

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  16. Content type: Primary Research

    Cholangiocarcinoma (CCA) is one of the worst prognosis cancer. The survival time of CCA patients is related to serum estrogen levels and estrogen has been found to enhance the proliferation and invasiveness of...

    Authors: Ekapot Singsuksawat, Chanitra Thuwajit, Komgrid Charngkaew and Peti Thuwajit

    Citation: Cancer Cell International 2018 18:25

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  17. Content type: Primary Research

    Cholesterol in lipid raft plays crucial role on cancer cell survival during metastasis of cancer cells. Cancer cells are reported to enrich cholesterol in lipid raft which make them more susceptible to cell de...

    Authors: Mukesh Kumar, Karuna Irungbam and Meena Kataria

    Citation: Cancer Cell International 2018 18:23

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  18. Content type: Primary Research

    Increasing evidence indicates that PIM1 is a potential prognostic marker and target for cancer treatment but its precise mechanisms of action remain to be determined in salivary adenoid cystic carcinoma (SACC)...

    Authors: Jiajie Xu, Xin Zhu, Qingling Li, Chao Chen, Zhenying Guo, Zhuo Tan, Chuanming Zheng and Minghua Ge

    Citation: Cancer Cell International 2018 18:22

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  19. Content type: Primary Research

    Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm whose pathogenesis is linked to the Philadelphia chromosome presence that generates the BCRABL1 fusion oncogene. Tyrosine kinase inhibitors ...

    Authors: Doralina do Amaral Rabello, Vivian D’Afonseca da Silva Ferreira, Maria Gabriela Berzoti-Coelho, Sandra Mara Burin, Cíntia Leticia Magro, Maira da Costa Cacemiro, Belinda Pinto Simões, Felipe Saldanha-Araujo, Fabíola Attié de Castro and Fabio Pittella-Silva

    Citation: Cancer Cell International 2018 18:26

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  20. Content type: Primary Research

    Pro-oxidant drugs have been proposed for treating certain cancers but the resistance developed by cancer cells to oxidative stress limits its potential use in clinics. To understand the mechanisms underlying r...

    Authors: Christophe Glorieux and Pedro Buc Calderon

    Citation: Cancer Cell International 2018 18:24

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  21. Content type: Primary Research

    We ought to explore the acquired somatic alterations, shedding light on genetic basis of somatic alterations in NB patients with chemotherapy.

    Authors: Chao Duan, Han Wang, Ying Chen, Ping Chu, Tianyu Xing, Chao Gao, Zhixia Yue, Jie Zheng, Mei Jin, Weiyue Gu and Xiaoli Ma

    Citation: Cancer Cell International 2018 18:21

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  22. Content type: Primary Research

    Papillary thyroid carcinoma (PTC) is one of the most frequent malignancies of the endocrine system, whose mechanisms of pathogenesis, progression and prognosis are still far from being clearly elucidated. Desp...

    Authors: Feng Chen, Yaqiong Jin, Lin Feng, Jie Zhang, Jun Tai, Jin Shi, Yongbo Yu, Jie Lu, Shengcai Wang, Xin Li, Ping Chu, Shujing Han, Shujun Cheng, Yongli Guo and Xin Ni

    Citation: Cancer Cell International 2018 18:20

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