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  1. Content type: Primary research

    Rhabdoid tumors (RTs) are aggressive tumors that occur most frequently in children under 2 years old, which often invade kidney (KRTs) and Center Nervous System, named Atypical teratoid/rhabdoid tumors (AT/RTs...

    Authors: Yanming Ren, Chuanyuan Tao, Xiliang Wang and Yan Ju

    Citation: Cancer Cell International 2018 18:190

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  2. Content type: Primary research

    Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune respons...

    Authors: Bangshun He, Tao Xu, Bei Pan, Yuqin Pan, Xuhong Wang, Jingwu Dong, Huiling Sun, Xueni Xu, Xiangxiang Liu and Shukui Wang

    Citation: Cancer Cell International 2018 18:191

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  3. Content type: Primary research

    2-Methoxyestradiol (2ME2) is an estradiol metabolite with well documented antiproliferative properties in many cancer cell lines. However, it is rapidly metabolised in vivo which limits its clinical applicatio...

    Authors: Mandie Botes, Tamarin Jurgens, Zohreh Riahi, Michelle Visagie, Rustelle Janse van Vuuren, Anna Margaretha Joubert and Iman van den Bout

    Citation: Cancer Cell International 2018 18:188

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  4. Content type: Primary research

    Accumulating evidence have indicated that regulatory T cells (Tregs) play an essential role in T cell-mediated immune response and development of multiple myeloma (MM). CD4+FoxP3+ T cells are composed of three ph...

    Authors: Ji-nuo Wang, Xin-xin Cao, Ai-lin Zhao, Hao Cai, Xuan Wang and Jian Li

    Citation: Cancer Cell International 2018 18:187

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  5. Content type: Primary research

    MiRNAs was recognized as vital regulators involved in cancer development. Radioresistance remains a major obstacle for effective treatment of cancers. The mechanisms on the miRNA-mediated radioresistance of ca...

    Authors: Chunbao Zang, Fangfang Zhao, Lei Hua and Youguang Pu

    Citation: Cancer Cell International 2018 18:186

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  6. Content type: Primary research

    Lung cancer is the leading cause of cancer deaths in the world. The major histopathological subtype of lung cancer is non-small cell lung cancer (NSCLC). Platinum-based therapy is the standard of care for pati...

    Authors: Heather E. Kapperman, Alicia A. Goyeneche and Carlos M. Telleria

    Citation: Cancer Cell International 2018 18:185

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  7. Content type: Primary research

    miRNA clusters are widely expressed across species, accumulating evidence has illustrated that miRNA cluster functioned more efficiently than single miRNA in cancer oncogenesis. It is likely that miRNA cluster...

    Authors: Zhikui Gao, Peng Zhang, Ming Xie, Han Gao, Lihong Yin and Ran Liu

    Citation: Cancer Cell International 2018 18:184

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  8. Content type: Primary research

    Cervical cancer (CC) is one of the most common cancers among females worldwide. Spindle and kinetochore-associated complex subunit 3 (SKA3), located on chromosome 13q, was identified as a novel gene involved i...

    Authors: Rong Hu, Ming-qing Wang, Wen-bo Niu, Yan-jing Wang, Yang-yang Liu, Ling-yu Liu, Ming Wang, Juan Zhong, Hai-yan You, Xiao-hui Wu, Ning Deng, Lu Lu and Lian-bo Wei

    Citation: Cancer Cell International 2018 18:183

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  9. Content type: Primary research

    Nuclear transcription factor kappa B (NF-κB) subunits exhibit crucial roles in tumorigenesis and chemo-sensitivity. Recent studies suggest that RelB, the key subunit of the alternative NF-κB pathway, plays a c...

    Authors: Xiaojun Zhou, Zhili Shan, Hengying Yang, Jingjing Xu, Wenjing Li and Feng Guo

    Citation: Cancer Cell International 2018 18:181

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  10. Content type: Primary research

    With the increasing popularity of water-pipe smoking (WPS), it is critical to comprehend how WPS may affect women’s health. The main goal of this study is to identify the potential outcome of WPS on human brea...

    Authors: Khaled W. Sadek, Mahmoud Y. Haik, Anas A. Ashour, Tahira Baloch, Tahar Aboulkassim, Amber Yasmeen, Semir Vranic, Asad Zeidan and Ala-Eddin Al Moustafa

    Citation: Cancer Cell International 2018 18:180

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  11. Content type: Review

    Some progresses have been made in research of long non-coding RNA (hereunder referred to as LncRNA) related to breast cancer. Lots of data about LncRNA transcription concerning breast cancer have been obtained...

    Authors: Xu Bin, Yang Hongjian, Zhang Xiping, Chen Bo, Yang Shifeng and Tang Binbin

    Citation: Cancer Cell International 2018 18:179

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  12. Content type: Primary research

    Deregulated Hippo signaling has been uncovered to be intricately involved in tumorigenesis. Transcriptional factor TEADs serve as key mediators of Hippo signaling and have been increasingly appreciated as puta...

    Authors: Wei Zhang, Jin Li, Yaping Wu, Han Ge, Yue Song, Dongmiao Wang, Hua Yuan, Hongbing Jiang, Yanling Wang and Jie Cheng

    Citation: Cancer Cell International 2018 18:178

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  13. Content type: Primary research

    Sorafenib is the standard targeted drug used to treat hepatocellular carcinoma (HCC), but the therapeutic response between individuals varies markedly. Recently, cytokine-based immunotherapy has been a topic o...

    Authors: Xiaoyan Ding, Wei Sun and Jinglong Chen

    Citation: Cancer Cell International 2018 18:176

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  14. Content type: Commentary

    Gao-Min Liu and Yao-Ming Zhang recently published a review entitled «Targeting FBPase is an emerging novel approach for cancer therapy» (Liu and Zhang in Cancer Cell Int 18:36, 2018). In this paper, the authors h...

    Authors: Philippe Icard, Ludovic Fournel, Antoine Coquerel, Joseph Gligorov, Marco Alifano and Hubert Lincet

    Citation: Cancer Cell International 2018 18:175

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  15. Content type: Primary research

    Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis. Unfortunately, the mechanisms underlying these pr...

    Authors: Yujie Feng, Xiao Hu, Guangwei Liu, Lianfang Lu, Wei Zhao, Fangzhen Shen, Kai Ma, Chuandong Sun, Chengzhan Zhu and Bingyuan Zhang

    Citation: Cancer Cell International 2018 18:173

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  16. Content type: Primary research

    Pancreatic cancer is characterized by its unsatisfying early detection rate, rapid disease progression and poor prognosis. Further studies on molecular mechanism and novel predictive biomarkers for pancreatic ...

    Authors: Defeng Sun, Haoyi Jin, Jun Zhang and Xiaodong Tan

    Citation: Cancer Cell International 2018 18:174

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  17. Content type: Primary research

    Galectin-3 as a β-galactoside-binding protein, has been found to be involved in tumor cell growth, anti-apoptosis, adhesion, angiogenesis, invasion, and distant metastases, indicating that it may play a pivota...

    Authors: Yi Wang, Shiwei Liu, Ye Tian, Yamin Wang, Qijie Zhang, Xiang Zhou, Xianghu Meng and Ninghong Song

    Citation: Cancer Cell International 2018 18:172

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  18. Content type: Primary research

    Cancer metastasis is the major reason for cancer related deaths, and the mechanism of cancer metastasis still unclear. RPLP1, a member of a group of proteins known as ribosomal proteins, is associated with tum...

    Authors: Zhixian He, Qian Xu, Xi Wang, Jun Wang, Xiangming Mu, Yunhui Cai, Yangyang Qian, Weiwei Shao and Zhimin Shao

    Citation: Cancer Cell International 2018 18:170

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  19. Content type: Primary research

    Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions...

    Authors: Xin-Xing Wang, Guang-Cheng Guo, Xue-Ke Qian, Dong-Wei Dou, Zhe Zhang, Xiao-Dong Xu, Xin Duan and Xin-Hong Pei

    Citation: Cancer Cell International 2018 18:171

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  20. Content type: Primary research

    Primary or acquired resistance to cetuximab often occurs during targeted therapy in metastatic colorectal cancer (mCRC) patients. In many cancers, the key role of the long noncoding RNA (lncRNA) urothelial car...

    Authors: Ying-nan Yang, Rui Zhang, Jing-wen Du, Heng-heng Yuan, Yan-jing Li, Xiao-li Wei, Xiao-xue Du, Shu-lin Jiang and Yu Han

    Citation: Cancer Cell International 2018 18:164

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  21. Content type: Primary research

    Mitochondrial fragmentation drastically regulates the viability of pancreatic cancer through a poorly understood mechanism. The present study used erlotinib to activate mitochondrial fragmentation and then inv...

    Authors: Jun Wan, Jie Cui, Lei Wang, Kunpeng Wu, Xiaoping Hong, Yulin Zou, Shuang Zhao and Hong Ke

    Citation: Cancer Cell International 2018 18:165

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  22. Content type: Primary research

    Gene knockout technologies involving programmable nucleases have been used to create knockouts in several applications. Gene editing using Zinc-finger nucleases (ZFNs), Transcription activator like effectors (...

    Authors: Sumitra Shankar, Ahalya Sreekumar, Deepti Prasad, Ani V. Das and M. Radhakrishna Pillai

    Citation: Cancer Cell International 2018 18:169

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  23. Content type: Primary research

    Inflammation is a major player in breast cancer (BC) progression. Allograft-inflammatory factor-1 (AIF1) is a crucial mediator in the inflammatory response. AIF1 reportedly plays a role in BC, but the mechanis...

    Authors: Ferial Amira Slim, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Simon Jacob, Caroline Diorio and Francine Durocher

    Citation: Cancer Cell International 2018 18:167

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  24. Content type: Primary research

    Drug resistance prevents the effective treatment of cancers. DNA methylation has been found to participate in the development of cancer drug resistance.

    Authors: Dabing Huang, Yong Wang, Yifu He, Gang Wang, Wei Wang, Xinghua Han, Yubei Sun, Lin Lin, Benjie Shan, Guodong Shen, Min Cheng, Geng Bian, Xiang Fang, Shilian Hu and Yueyin Pan

    Citation: Cancer Cell International 2018 18:168

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  25. Content type: Primary research

    Follistatin (FST), an activin-binding protein, inhibits activin action by interfering with activin binding to its receptor. The prognostic value of FST has been studied in various cancers. However, these studi...

    Authors: Pengyu Zhang, Yingxin Ruan, Jun Xiao, Fangfang Chen and Xuejun Zhang

    Citation: Cancer Cell International 2018 18:162

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  26. Content type: Primary research

    Small cell lung cancer (SCLC) is a highly malignant cancer, and over 70% of patients with SCLC present with the metastatic disease. We aimed to explore some novel differentially expressed genes (DEGs) or micro...

    Authors: Zhonghao Wang, Bei Lu, Lixin Sun, Xi Yan and Jinzhi Xu

    Citation: Cancer Cell International 2018 18:161

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  27. Content type: Primary research

    In an earlier study, we investigated the expression of tight junction protein claudins (CLDNs) in human osteosarcoma (OS) cells, and the CLDN2 was found to be down-regulated in primary tumor cells compared wit...

    Authors: Xiaowei Zhang, Haiming Wang, Qian Li and Tao Li

    Citation: Cancer Cell International 2018 18:160

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  28. Content type: Primary research

    While the somatic mutation profiles of renal cell carcinoma (RCC) have been revealed by several studies worldwide, the overwhelming majority of those were not derived from Chinese patients. The landscape of so...

    Authors: Jie Wang, Zhijun Xi, Jianzhong Xi, Hanshuo Zhang, Juan Li, Yuchao Xia and Yuanxue Yi

    Citation: Cancer Cell International 2018 18:159

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  29. Content type: Review

    Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs)...

    Authors: Babak Otoukesh, Bahram Boddouhi, Mehdi Moghtadaei, Peyman Kaghazian and Maria Kaghazian

    Citation: Cancer Cell International 2018 18:158

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  30. Content type: Primary research

    As newly identified Wnt enhancer, R-spondin gene family members have been linked to various cancers; however, their role in isocitrate dehydrogenase-wildtype subtype of human glioblastoma (GBM) cells remains u...

    Authors: Si Liu, Kin Pong U, Jieting Zhang, Lai Ling Tsang, Jiawei Huang, Shui Ping Tu and Xiaohua Jiang

    Citation: Cancer Cell International 2018 18:156

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  31. Content type: Primary research

    Increasing evidence suggests a critical role for long noncoding RNAs (LncRNAs) and pseudogenes in cancer. Renal cell carcinoma (RCC), the most common primary renal neoplasm, is highly aggressive and difficult ...

    Authors: Binghai Chen, Chengyue Wang, Jin Zhang, Yang Zhou, Wei Hu and Tao Guo

    Citation: Cancer Cell International 2018 18:157

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  32. Content type: Primary research

    Although mounting non-hereditary colorectal cancer (NHCRC) associated single nucleotide polymorphisms (SNPs) have been observed, no field synopsis and meta-analysis has been conducted through systematically as...

    Authors: Jing Wen, Qian Xu and Yuan Yuan

    Citation: Cancer Cell International 2018 18:155

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  33. Content type: Review

    BORIS (CTCFL) is a DNA binding protein which is involved in tumorigenesis. Although, there are different opinions on the level of gene expression and function of BORIS in normal and cancer tissues, the results...

    Authors: Sara Soltanian and Hesam Dehghani

    Citation: Cancer Cell International 2018 18:154

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  34. Content type: Primary research

    Chronic inflammation is deemed to play a significant effect on initiation and progression of esophageal squamous cell carcinoma (ESCC). In current study, we investigated the prognostic and predictive role of a...

    Authors: Qiu-Fang Gao, Jia-Cong Qiu, Xiao-Hong Huang, Yan-Mei Xu, Shu-Qi Li, Fan Sun, Jing Zhang, Wei-Ming Yang, Qing-Hua Min, Yu-Huan Jiang, Qing-Gen Chen, Lei Zhang, Xiao-Zhong Wang and Hou-Qun Ying

    Citation: Cancer Cell International 2018 18:153

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  35. Content type: Review

    Several epidemiological researches have indicated that microvessel density (MVD), reflecting angiogenesis, was a negatively prognostic factor of cervical cancer. However, the results were inconsistent. Therefo...

    Authors: Xiaoli Hu, Hailing Liu, Miaomiao Ye and Xueqiong Zhu

    Citation: Cancer Cell International 2018 18:152

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  36. Content type: Primary research

    Extranodal NK/T-cell lymphoma, nasal type (ENKL) is a distinct clinicopathological entity and EBV-associated disease that is highly aggressive. Many patients had failed to respond to conventional chemotherapy ...

    Authors: Xudong Zhang, Xiaorui Fu, Meng Dong, Zhenzhen Yang, Shaoxuan Wu, Mijing Ma, Zhaoming Li, Xinhua Wang, Ling Li, Xin Li, Zhenchang Sun, Yu Chang, Feifei Nan, Jiaqin Yan, Yun Mao, Mingzhi Zhang…

    Citation: Cancer Cell International 2018 18:150

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  37. Content type: Primary research

    Marsdenia tenacissima is an herb medicine which has been utilized to treat malignant diseases for decades. The M. tenacissima extract (MTE) shows significant anti-proliferation activity against non-small cell lun...

    Authors: Yan-Na Jiao, Li-Na Wu, Dong Xue, Xi-Juan Liu, Zhi-Hua Tian, Shan-Tong Jiang, Shu-Yan Han and Ping-Ping Li

    Citation: Cancer Cell International 2018 18:149

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  38. Content type: Primary research

    Arterialized vein flap is a kind of unphysiological flap. Unphysiological reconstruction of blood circulation leads to higher load than that supported by physiological flap and is the culprit of flap swelling,...

    Authors: Zheng Li, Zhen-wei Zhang, Shao-xiao Yu, Jia-chuan Zhuang, Yu-hai Ke, Yi Xiong, Hui-xin Lin and Wen-feng Chen

    Citation: Cancer Cell International 2018 18:148

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  39. Content type: Primary research

    Drug screening for the identification of compounds with anticancer activity is commonly performed using cell lines cultured under normal oxygen pressure and physiological pH. However, solid tumors are characte...

    Authors: Paola Pellegrini, Jason T. Serviss, Thomas Lundbäck, Nicolo Bancaro, Magdalena Mazurkiewicz, Iryna Kolosenko, Di Yu, Martin Haraldsson, Padraig D’Arcy, Stig Linder and Angelo De Milito

    Citation: Cancer Cell International 2018 18:147

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  40. Content type: Primary research

    The molecular mechanism of Epstein–Barr virus (EBV)-associated gastric cancer (EBVaGC) remains elusive. A collection of molecular regulators including transcription factor and noncoding RNA (ncRNAs) may affect...

    Authors: Jing-jing Jing, Ze-yang Wang, Hao Li, Li-ping Sun and Yuan Yuan

    Citation: Cancer Cell International 2018 18:146

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  41. Content type: Primary research

    Ovarian cancer is the fifth leading cause of cancer deaths in women worldwide. LncRNACCAT1 was reported to play a critical role in cell metastasis of ovarian cancer. However, little is known about the detailed me...

    Authors: Yang Mu, Na Li and Yu-Lan Cui

    Citation: Cancer Cell International 2018 18:145

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  42. Content type: Primary research

    Retinoic acid-induced protein I (RIG-I), known as a cytoplastic pattern recognition receptor, can recognize exogenous viral RNAs, and then initiate immune response. Recently, numerous studies also showed that ...

    Authors: Lujun Chen, Jun Feng, Shaoxian Wu, Bin Xu, You Zhou, Changping Wu and Jingting Jiang

    Citation: Cancer Cell International 2018 18:144

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  43. Content type: Primary research

    Pancreatic cancer, one of the most aggressive malignancies, ranks the fourth cause of cancer-related death worldwide. Aberrantly expressed long non-coding RNAs (lncRNAs) functioned as oncogenes or tumor suppre...

    Authors: Yong An, Xue-min Chen, Yong Yang, Feng Mo, Yong Jiang, Dong-lin Sun and Hui-hua Cai

    Citation: Cancer Cell International 2018 18:143

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  44. Content type: Primary research

    Breast cancer is the leading cause of oncological mortality among women. Efficient detection of cancer cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to imp...

    Authors: LingLi Hou, Jiancheng Tu, Fangxiong Cheng, Hongwei Yang, Fei Yu, Minghua Wang, Jiubo Liu, Jinbo Fan and Guojun Zhou

    Citation: Cancer Cell International 2018 18:142

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