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  1. Primary Research

    The role of miR-485-5p/NUDT1 axis in gastric cancer

    Cancers can survive the oxidative conditions by upregulating nucleoside diphosphate linked moiety X-type motif 1 (NUDT1). However, the mechanisms underlying gastric carcinogenesis and the dys-regulation of NUD...

    Jingjing Duan, Haiyang Zhang, Shuang Li, Xinyi Wang, Haiou Yang, Shunchang Jiao and Yi Ba

    Cancer Cell International 2017 17:92

    Published on: 17 October 2017

  2. Primary Research

    Integrated genomic characterization of cancer genes in glioma

    Cancers are caused by the acquisition of somatic mutations. Numerous efforts have been made to characterize the key driver genes and pathways in glioma, however, the etiology of glioma is still not completely ...

    Aijun Liang, Bin Zhou and Wei Sun

    Cancer Cell International 2017 17:90

    Published on: 13 October 2017

  3. Primary Research

    Down-regulation of IFITM1 and its growth inhibitory role in cervical squamous cell carcinoma

    Cervical cancer is a major cause of death in women worldwide. Interferon-induced transmembrane protein 1 (IFITM1) is involved in antivirus defense, cell adhesion, and carcinogenesis in different tissues. Howev...

    Weinan Zheng, Zhimin Zhao, Xinan Yi, Qiangqiang Zuo, Hongtao Li, Xiaoqing Guo, Dongmei Li, Hongchang He, Zemin Pan, Peiwen Fan, Feng Li, Yanhong Liao and Renfu Shao

    Cancer Cell International 2017 17:88

    Published on: 10 October 2017

  4. Primary Research

    Identification of genes and pathways potentially related to PHF20 by gene expression profile analysis of glioblastoma U87 cell line

    Glioblastoma is the most common and aggressive brain tumor associated with a poor prognosis. Plant homeodomain finger protein 20 (PHF20) is highly expressed in primary human gliomas and its expression is assoc...

    Tianlong Liu, Tiejun Zhang, Feng Zhou, Jitao Wang, Xiaohu Zhai, Nan Mu, Jongsun Park, Minna Liu, Wenxing Liu, Peijin Shang, Yi Ding, Aidong Wen and Yuwen Li

    Cancer Cell International 2017 17:87

    Published on: 4 October 2017

  5. Primary Research

    Blocking ERK1/2 signaling impairs TGF-β1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells

    Transforming growth factor-β (TGF-β) plays a paradoxical role in cancer: it suppresses proliferation at early stages but promotes metastasis at late stages. This cytokine is upregulated in cholangiocarcinoma a...

    Phaijit Sritananuwat, Natthaporn Sueangoen, Parichut Thummarati, Kittiya Islam and Tuangporn Suthiphongchai

    Cancer Cell International 2017 17:85

    Published on: 26 September 2017

  6. Primary Research

    Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis

    Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated the efficacy of curcumin in sensitizing chemothe...

    Qian-Mei Zhou, Yang Sun, Yi-Yu Lu, Hui Zhang, Qi-Long Chen and Shi-Bing Su

    Cancer Cell International 2017 17:84

    Published on: 26 September 2017

  7. Primary Research

    The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data

    Ubiquitin-conjugating enzyme E2C (UBE2C) has been previously reported to correlate with the malignant progression of various human cancers, however, the exact molecular function of UBE2C in breast carcinoma (B...

    Chao-hua Mo, Li Gao, Xiao-fei Zhu, Kang-lai Wei, Jing-jing Zeng, Gang Chen and Zhen-bo Feng

    Cancer Cell International 2017 17:83

    Published on: 25 September 2017

  8. Primary Research

    The role of pparγ and autophagy in ros production, lipid droplets biogenesis and its involvement with colorectal cancer cells modulation

    In cancer cells, autophagy can act as both tumor suppressor, when autophagic event eliminates cellular contends which exceeds the cellular capacity of regenerate promoting cell death, and as a pro-survival age...

    José Antonio Fagundes Assumpção, Kelly Grace Magalhães and José Raimundo Corrêa

    Cancer Cell International 2017 17:82

    Published on: 15 September 2017

  9. Primary Research

    SNP rs3202538 in 3′UTR region of ErbB3 regulated by miR-204 and miR-211 promote gastric cancer development in Chinese population

    ErbB3 is an oncogene which has proliferation and metastasis promotion effects by several signaling pathways. However, the individual expression difference regulated by miRNA was almost still unknown. We focuse...

    Yaxiang Shi, Xuan Chen, Biao Xi, Xiaowen Yu, Jun Ouyang, Chunxia Han, Yucheng Qin, Defeng Wu and Hong Shen

    Cancer Cell International 2017 17:81

    Published on: 13 September 2017

  10. Primary Research

    Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway

    Cisplatin has been used in the treatment of many cancers, including laryngeal cancer; however, its efficacy can be reduced due to the development of drug resistance. This study aimed to investigate whether int...

    Qiang Fu, Pengruofeng Liu, Xiumei Sun, Shanshan Huang, Fengchan Han, Lili Zhang, Yannan Xu and Tingyan Liu

    Cancer Cell International 2017 17:79

    Published on: 5 September 2017

  11. Primary Research

    The role of REST and HDAC2 in epigenetic dysregulation of Nav1.5 and nNav1.5 expression in breast cancer

    Increased expression of voltage-gated sodium channels (VGSCs) have been implicated with strong metastatic potential of human breast cancer in vitro and in vivo where the main culprits are cardiac isoform Nav1....

    Nur Sabrina Kamarulzaman, Hemaniswarri Dewi Dewadas, Chiuan Yee Leow, Nik Soriani Yaacob and Noor Fatmawati Mokhtar

    Cancer Cell International 2017 17:74

    Published on: 1 August 2017

  12. Research

    Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines

    Meningioma tumors arise in arachnoid membranes, and are the most reported central nervous system (CNS) tumors worldwide. Up to 20% of grade I meningioma tumors reoccur and currently predictive cancer stem cell...

    Ishaq Khan, Saleh Baeesa, Mohammed Bangash, Hans-Juergen Schulten, Fahad Alghamdi, Hanadi Qashqari, Nawal Madkhali, Angel Carracedo, Mohamad Saka, Awatif Jamal, Jaudah Al-Maghrabi, Mohammed AlQahtani, Saleh Al-Karim, Ghazi Damanhouri, Kulvinder Saini, Adeel Chaudhary…

    Cancer Cell International 2017 17:72

    Published on: 21 July 2017

  13. Primary Research

    EP300 single nucleotide polymorphism rs20551 correlates with prolonged overall survival in diffuse large B cell lymphoma patients treated with R-CHOP

    Rituximab combined with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) is used as standard frontline regimen for diffuse large B-cell lymphoma (DLBCL). The landscape of somatic mutations in D...

    Jiao Li, Ning Ding, Xiaogan Wang, Lan Mi, Lingyan Ping, Xuan Jin, Yalu Liu, Zhitao Ying, Yan Xie, Weiping Liu, Yuqin Song and Jun Zhu

    Cancer Cell International 2017 17:70

    Published on: 14 July 2017

  14. Review

    Chemotherapy and tumor microenvironment of pancreatic cancer

    Pancreatic cancer is an extremely dismal malignance. Chemotherapy has been widely applied to treat this intractable tumor. It has exclusive tumor microenvironment (TME), characterized by dense desmoplasia and ...

    Qiaofei Liu, Quan Liao and Yupei Zhao

    Cancer Cell International 2017 17:68

    Published on: 5 July 2017

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