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  1. Metastatic prostate cancer (PCa) is a lethal tumor. However, the molecular mechanisms underlying PCa progression have not been fully elucidated.

    Authors: Feifeng Song, Yiwen Zhang, Zongfu Pan, Xiaoping Hu, Yaodong Yi, Xiaochun Zheng, Haibin Wei and Ping Huang

    Citation: Cancer Cell International 2021 21:559

    Content type: Primary research

    Published on:

  2. Squamous cell carcinoma of the head and neck (SCCHN) is one of the most common types of cancer that cause a substantial number of cancer-related deaths. Our previous study has revealed that makorin ring finger...

    Authors: Shuiting Zhang, Chao Liu, Guo Li, Yong Liu, Xingwei Wang and Yuanzheng Qiu

    Citation: Cancer Cell International 2021 21:557

    Content type: Primary research

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  3. Brain metastasis is an important cause of increased mortality in patients with non-small cell lung cancer (NSCLC). In brain metastasis, the blood–brain barrier (BBB) is frequently impaired, forming blood–tumor...

    Authors: Ling-yun Ye, Li-xiang Sun, Xiu-hua Zhong, Xue-song Chen, Song Hu, Rong-rong Xu, Xiao-ning Zeng, Wei-ping Xie and Hui Kong

    Citation: Cancer Cell International 2021 21:556

    Content type: Primary research

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  4. Wilms tumor (WT) is the most common renal tumor in childhood. Among others, MYCN copy number gain and MYCN P44L and MAX R60Q mutations have been identified in WT. MYCN encodes a transcription factor that requires...

    Authors: Ovidio Jiménez Martín, Andreas Schlosser, Rhoikos Furtwängler, Jenny Wegert and Manfred Gessler

    Citation: Cancer Cell International 2021 21:555

    Content type: Primary research

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  5. Colorectal cancer liver metastases (CRLM) has not been identified as a unified disease entity due to the differences in the severity of metastatic disease and tumor aggressiveness. A screen for specific progno...

    Authors: Jianhong Peng, Weihao Li, Wenhua Fan, Rongxin Zhang, Xinyue Li, Binyi Xiao, Yuejin Dong, Desen Wan, Zhizhong Pan, Junzhong Lin and Xiaojun Wu

    Citation: Cancer Cell International 2021 21:554

    Content type: Primary research

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  6. Oral squamous cell carcinoma (OSCC) is one of malignant tumors in oral and maxillofacial region with high fatality. Huanglianjiedu Decoction (HLJDD) is a well-known traditional Chinese medicinal prescription, ...

    Authors: Lejun Zhang, Zhaoting Ling, Zhengqiang Hu, Guanmin Meng, Xinqiang Zhu and Huifang Tang

    Citation: Cancer Cell International 2021 21:553

    Content type: Primary research

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  7. Cancer-associated fibroblasts (CAFs) contribute notably to colorectal cancer (CRC) tumorigenesis, stiffness, angiogenesis, immunosuppression and metastasis, and could serve as a promising therapeutic target. O...

    Authors: Hang Zheng, Heshu Liu, Yang Ge and Xin Wang

    Citation: Cancer Cell International 2021 21:552

    Content type: Primary research

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  8. Emerging studies have shown that long noncoding RNAs (lncRNAs) predominantly function in the carcinogenesis of multiple developing human tumors. The current study aimed to investigate the underlying mechanisms...

    Authors: Ru-nan Zhang, Dong-mei Wu, Li-ping Wu and Guo-wei Gao

    Citation: Cancer Cell International 2021 21:550

    Content type: Primary research

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  9. The cause and underlying molecular mechanisms of head and neck squamous cell carcinoma (HNSCC) are unclear. Our study aims to identify the key genes associated with HNSCC and reveal potential biomarkers.

    Authors: Yuchu Ye, Jingyi Wang, Faya Liang, Pan Song, Xiaoqing Yan, Sangqing Wu, Xiaoming Huang and Ping Han

    Citation: Cancer Cell International 2021 21:549

    Content type: Primary research

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  10. Immune thrombocytopenia (ITP) is an autoimmune haemorrhagic disease whose pathogenesis is associated with bone marrow megakaryocyte maturation disorder and destruction of the haematopoietic stem cell microenvi...

    Authors: Rui-Jie Sun, Dong-mei Yin, Dai Yuan, Shu-yan Liu, Jing-jing Zhu and Ning-ning Shan

    Citation: Cancer Cell International 2021 21:548

    Content type: Primary research

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  11. Colorectal cancer (CRC) is one of the most highly malignant tumors and has a complicated pathogenesis. A preliminary study identified syntrophin beta 1 (SNTB1) as a potential oncogene in CRC. However, the clin...

    Authors: Liya Liu, Youqin Chen, Xiaoying Lin, Meizhu Wu, Jiapeng Li, Qiurong Xie, Thomas J. Sferra, Yuying Han, Huixin Liu, Liujing Cao, Mengying Yao, Jun Peng and Aling Shen

    Citation: Cancer Cell International 2021 21:547

    Content type: Primary research

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  12. Malignant mesothelioma (MM) is a very aggressive tumor that develops from mesothelial cells, mainly due to asbestos exposure. MM is categorized into three major histological subtypes: epithelioid, sarcomatoid,...

    Authors: Tatsuhiro Sato, Hayao Nakanishi, Ken Akao, Maho Okuda, Satomi Mukai, Tohru Kiyono and Yoshitaka Sekido

    Citation: Cancer Cell International 2021 21:546

    Content type: Primary research

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  13. Leukemia is a lethal cancer in which white blood cells undergo proliferation and immature white blood cells are seen in the bloodstream. Without diagnosis and management in early stages, this type of cancer ca...

    Authors: Parinaz Zivarpour, Jamal Hallajzadeh, Zatollah Asemi, Fatemeh Sadoughi and Mehran Sharifi

    Citation: Cancer Cell International 2021 21:544

    Content type: Review

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  14. UBTF is an HMGB-box DNA binding protein and a necessary Pol I/Pol II basal transcription factor. It has been found that UBTF involves in carcinogenesis and progression of a few cancers. Nevertheless, the the b...

    Authors: Jian Zhang, Jiaojiao Zhang, Wenli Liu, Rui Ge, Tianyuan Gao, Qiong Tian, Xin Mu, Lingyu Zhao and Xu Li

    Citation: Cancer Cell International 2021 21:543

    Content type: Primary research

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  15. Chemoresistance is a critical risk problem for breast cancer treatment. However, mechanisms by which chemoresistance arises remains to be elucidated. The expression of T-box transcription factor 15 (TBX-15) wa...

    Authors: Cheng-Fei Jiang, Yun-Xia Xie, Ying-Chen Qian, Min Wang, Ling-Zhi Liu, Yong-Qian Shu, Xiao-Ming Bai and Bing-Hua Jiang

    Citation: Cancer Cell International 2021 21:542

    Content type: Primary research

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  16. Osteosarcoma (OS) is a malignant tumor originating from mesenchymal stem cells, and has an extremely high fatality rate and ability to metastasize. Although mounting evidence suggests that miR-769-5p is strong...

    Authors: Wanshun Liu, Binyu Wang, Ao Duan, Kai Shen, Qi Zhang, Xiaolu Tang, Yongzhong Wei, Jian Tang and Sheng Zhang

    Citation: Cancer Cell International 2021 21:541

    Content type: Primary research

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  17. Cumulative CT radiation damage was positively correlated with increased tumor risks. Although it has recently been known that non-radiation MRI is alternative for pulmonary imaging. There is little known about...

    Authors: Qinqin Yan, Yinqiao Yi, Jie Shen, Fei Shan, Zhiyong Zhang, Guang Yang and Yuxin Shi

    Citation: Cancer Cell International 2021 21:539

    Content type: Primary research

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  18. Increased tryptophan (Trp) metabolism by indoleamine 2,3-dioxygenase (IDO)/tryptophan 2,3-dioxygenase (TDO) represents one of the most studied pathways for immunosuppression in tumor tissues. However, the pro-...

    Authors: Zhengzhong Wu, Leye Yan, Junqing Lin, Kun Ke and Weizhu Yang

    Citation: Cancer Cell International 2021 21:538

    Content type: Primary research

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  19. Gastric cancer (GC) is a malignant tumor and microRNAs (miRNAs) are closely connected to GC development. The purpose of this study is to investigate the effect of miR-140-3p on the occurrence and metastasis of...

    Authors: Zhengguang Wang, Ke Chen, Dongchang Li, Mengding Chen, Angqing Li and Jian Wang

    Citation: Cancer Cell International 2021 21:537

    Content type: Primary research

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  20. Tertiary lymphoid structures (TLSs), organizationally resemble lymph nodes, are frequently present in breast cancer (BCa). It is usually, but not always, associated with a positive prognosis or immunotherapy r...

    Authors: Na-Na Zhang, Feng-Jin Qu, Hao Liu, Zhu-Jun Li, Yu-Chi Zhang, Xuan Han, Zi-Yu Zhu and Yi Lv

    Citation: Cancer Cell International 2021 21:536

    Content type: Review

    Published on:

  21. Ephrin receptors (Eph) and their ligands, called ephrins, function in various disease processes. However, the expression level and prognostic value of Eph/ephrins in lung adenocarcinoma (LUAD) are still unclear.

    Authors: Mingming Deng, Run Tong, Zhe Zhang, Tao Wang, Chaonan Liang, Xiaoming Zhou and Gang Hou

    Citation: Cancer Cell International 2021 21:535

    Content type: Primary research

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  22. Breast cancer (BC) is one of the most common cancers and the leading cause of death in women. Previous studies have demonstrated that FAM49B is implicated in several tumor progression, however, the role and me...

    Authors: Yanhui Li, Yue Xiong, Zhen Wang, Jianjun Han, Sufang Shi, Jinglan He, Na Shen, Wenjuan Wu, Rui Wang, Weiwei Lv, Yajun Deng and Weiguang Liu

    Citation: Cancer Cell International 2021 21:534

    Content type: Primary research

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  23. Increasing evidence indicates that the aberrant expression of circular RNAs (circRNAs) is involved in the pathogenesis and progression of lung adenocarcinoma (LUAC). However, the function and molecular mechani...

    Authors: Jun Wan, Guanggui Ding, Min Zhou, Xiean Ling and Zhanpeng Rao

    Citation: Cancer Cell International 2021 21:533

    Content type: Primary research

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  24. Cervical cancer (CC) is one of the most common malignant tumors in women. In order to identify the functional roles and the interaction between mRNA and non-coding RNA (ncRNA, including lncRNA, circRNA and miR...

    Authors: Huimin Lv, Shanshan Jin, Binbin Zou, Yuxiang Liang, Jun Xie and Suhui Wu

    Citation: Cancer Cell International 2021 21:532

    Content type: Primary research

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  25. The role of Diphenyldifluoroketone (EF24), a synthetic analogue of curcumin with noteworthy antitumor potential, remains unclear in non-small cell lung cancer (NSCLC). Herein, the inhibitory effect of EF24 on ...

    Authors: Minghui Chang, Ming Shang, Fang Yuan, Wei Guo and Cuijuan Wang

    Citation: Cancer Cell International 2021 21:531

    Content type: Primary research

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  26. The transcription factor cyclic-AMP response element-binding protein 1 (CREB1) responds to cAMP level and controls the expression of target genes, which regulates nutrition partitioning. The promoters of CREB1...

    Authors: Tianyu Zheng, Jinrong Huang, Xi Xiang, Siyuan Li, Jiaying Yu, Kunli Qu, Zhe Xu, Peng Han, Zhanying Dong, Yang Liu, Fengping Xu, Huanming Yang, Marja Jäättelä, Yonglun Luo and Bin Liu

    Citation: Cancer Cell International 2021 21:530

    Content type: Primary research

    Published on:

  27. Targeting tumor microenvironment (TME) may provide therapeutic activity and selectivity in treating cancers. Therefore, an improved understanding of the mechanism by which drug targeting TME would enable more ...

    Authors: Jinglin Zhu, Ruifei Huang, Ruijie Yang, Yue Xiao, Jiangna Yan, Chunli Zheng, Wei Xiao, Chao Huang and Yonghua Wang

    Citation: Cancer Cell International 2021 21:529

    Content type: Primary research

    Published on:

  28. Exosome-mediated crosstalk between cancer cells and immune cells contributes to tumor growth. In this study, we investigated the mechanism underlying the exosome-mediated immune escape of colorectal cancer (CR...

    Authors: Yiwen Huang, Yanbo Luo, Wentao Ou, Yuanyuan Wang, Dong Dong, Xiaowen Peng and Yuqi Luo

    Citation: Cancer Cell International 2021 21:528

    Content type: Primary research

    Published on:

  29. Migration is one of the five major behaviors of cells. Although RhoC—a classic member of the Rho gene family—was first identified in 1985, functional RhoC data have only been widely reported in recent years. C...

    Authors: Yingyue Lou, Yuhan Jiang, Zhen Liang, Bingzhang Liu, Tian Li and Duo Zhang

    Citation: Cancer Cell International 2021 21:527

    Content type: Review

    Published on:

  30. The epigenetic regulator additional sex combs-like 1 (ASXL1) is an adverse prognostic factor in acute myeloid leukemia (AML). However, the mutational spectrum and prognostic factors of ASXL1-mutated (ASXL1+) AML ...

    Authors: Yi Fan, Linxiao Liao, Yajun Liu, Zhenzhen Wu, Chong Wang, Zhongxing Jiang, Shujuan Wang and Yanfang Liu

    Citation: Cancer Cell International 2021 21:526

    Content type: Primary research

    Published on:

  31. Non-small cell lung cancer (NSCLC) is a malignancy with considerable morbidity and mortality. Abnormal metabolism is a hallmark of cancer; however, the mechanism of glycolysis regulation in NSCLC progression i...

    Authors: Qian Hua, Dongliang Wang, Lin Zhao, Zhihui Hong, Kairu Ni, Yizhen Shi, Zengli Liu and Baoming Mi

    Citation: Cancer Cell International 2021 21:525

    Content type: Primary research

    Published on:

  32. Increasing evidence suggests that hepatitis C virus (HCV) infection is associated with non-Hodgkin’s lymphoma (NHL). However, no clear consensus has been reached about the clinical features and effective treat...

    Authors: Minyue Zhang, Fei Gao, Ling Peng, Lijing Shen, Peng Zhao, Beiwen Ni, Jian Hou and Honghui Huang

    Citation: Cancer Cell International 2021 21:524

    Content type: Review

    Published on:

  33. Hepatocellular carcinoma (HCC) has become a global health issue of wide concern due to its high prevalence and poor therapeutic efficacy. Both tumor doubling time (TDT) and immune status are closely related to...

    Authors: Genhao Zhang, Lisa Su, Xianping Lv and Qiankun Yang

    Citation: Cancer Cell International 2021 21:522

    Content type: Primary research

    Published on:

  34. Patient-derived organoids (PDO) have been proposed as a novel in vitro method of drug screening for different types of cancer. However, to date, extrahepatic biliary tract carcinoma (eBTC) PDOs have not yet be...

    Authors: Zhiwei Wang, Yinghao Guo, Yun Jin, Xiaoxiao Zhang, Hao Geng, Guangyuan Xie, Dan Ye, Yuanquan Yu, Daren Liu, Donger Zhou, Baizhou Li, Yan Luo, Shuyou Peng and Jiangtao Li

    Citation: Cancer Cell International 2021 21:519

    Content type: Primary research

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  35. There is a lack of effective treatments for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). Furthermore, the response rate of NPC patients to programmed death 1 (PD-1) inhibitors is approximately 20...

    Authors: Ao Zhang, Guanqing Zhong, Luocan Wang, Rongzeng Cai, Runkun Han, Caixia Xu, Shulin Chen, Peng Sun and Hao Chen

    Citation: Cancer Cell International 2021 21:518

    Content type: Primary research

    Published on:

  36. The gamma-glutamyl transferase (GGT) to alanine aminotransferase (ALT) ratio has been reported as an effective predictor of the severity of hepatitis and HCC. The purpose of this study was to determine the rol...

    Authors: Zhifeng Zhao, Yiming Zhu, Xiaochun Ni, Jiayun Lin, Hongjie Li, Lei Zheng, Chihao Zhang, Xiaoliang Qi, Haizhong Huo, Xiaolou Lou, Qiang Fan, Yongyang Bao and Meng Luo

    Citation: Cancer Cell International 2021 21:517

    Content type: Primary research

    Published on:

  37. The WNT gene family plays an important role in the occurrence and development of malignant tumors, but its involvement has not been systematically analyzed in uterine corpus endometrial carcinoma (UCEC). This ...

    Authors: Yuexin Hu, Mingjun Zheng, Dandan Zhang, Rui Gou, Ouxuan Liu, Shuang Wang and Bei Lin

    Citation: Cancer Cell International 2021 21:516

    Content type: Primary research

    Published on:

  38. DNA methylation plays a crucial role in multiple cellular processes such as gene regulation, chromatin stability, and genetic imprinting. In mammals, DNA methylation is achieved by DNA methyltransferases (DNMT...

    Authors: Ramesh Elango, Radhakrishnan Vishnubalaji, Hibah Shaath and Nehad M. Alajez

    Citation: Cancer Cell International 2021 21:515

    Content type: Primary research

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  39. ALDOA is a glycolytic enzyme found mainly in developing embryos, adult muscle and various malignant tumours, including pancreatic tumours. Our previous study revealed that ALDOA, an oncogene, can promote the p...

    Authors: Haidi Chen, Zeng Ye, Xiaowu Xu, Yi Qin, Changfeng Song, Guixiong Fan, Haifeng Hu, Yuheng Hu, Xianjun Yu, Wensheng Liu, Shunrong Ji and Wenyan Xu

    Citation: Cancer Cell International 2021 21:514

    Content type: Primary research

    Published on:

  40. Unilateral breast cancer (UBC) patients with germline pathogenic BRCA1/2 variants have a higher risk of developing contralateral breast cancer (CBC) and need contralateral risk-reducing local treatments, includin...

    Authors: Ziqi Jia, Jiaxin Li, Yuelun Zhang, Xin Wang, Jiahua Xing, Zeyu Xing, Xin Huang, Gang Liu, Menglu Zhang, Kexin Feng, Jiang Wu, Wenyan Wang, Jie Wang, Jiaqi Liu and Xiang Wang

    Citation: Cancer Cell International 2021 21:512

    Content type: Review

    Published on:

  41. The development of multiple myeloma (MM) is considered to involve a multistep transformation process, but the role of cytogenetic abnormalities and molecular alterations in determining the cell fate of multipl...

    Authors: Zhiyong Zeng, Junfang Lin, Kejie Zhang, Xizhe Guo, Xiaoqiang Zheng, Apeng Yang and Junmin Chen

    Citation: Cancer Cell International 2021 21:511

    Content type: Primary research

    Published on:

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