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  1. Content type: Primary Research

    Forty years ago the actin cytoskeleton was determined to be disrupted in fibroblasts from persons with DNA repair-defective, hereditary colon cancer, with no clear connection between the cytoskeleton and DNA r...

    Authors: Nicolette M. Clark, Carlos A. Garcia Galindo, Vandan K. Patel, Michele L. Parry, Rebecca J. Stoll, John M. Yavorski, Elizabeth P. Pinkason, Edna M. Johnson, Chelsea M. Walker, Joseph Johnson, Wade J. Sexton, Domenico Coppola and George Blanck

    Citation: Cancer Cell International 2017 17:121

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  2. Content type: Primary Research

    Erythropoietin (EPO) is a hypoxia-inducible stimulator of erythropoiesis. Besides its traditional application in anemia therapy, it offers an effective treatment in the cancer patients, especially those who re...

    Authors: Shuo Miao, Su-Mei Wang, Xue Cheng, Yao-Feng Li, Qing-Song Zhang, Gang Li, Song-Qing He, Xiao-Ping Chen and Ping Wu

    Citation: Cancer Cell International 2017 17:119

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  3. Content type: Primary Research

    Pemetrexed (PEM) is an anti-cancer agent targeting DNA and RNA synthesis, and clinically in use for mesothelioma and non-small cell lung carcinoma. A mechanism of resistance to PEM is associated with elevated ...

    Authors: Yiyang Qin, Ikuo Sekine, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Michiko Hanazono, Naoto Yamaguchi and Masatoshi Tagawa

    Citation: Cancer Cell International 2017 17:120

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  4. Content type: Primary Research

    Hepatocellular carcinoma (HCC) remains one of the most lethal cancers. MicroRNA-155 (miR-155) and collagen triple helix repeat containing 1 (CTHRC1) were found to be involved in hepatocarcinogenesis, but thei...

    Authors: Gang Chen, Dongdong Wang, Xiongqi Zhao, Jun Cao, Yingpeng Zhao, Fan Wang, Jianhua Bai, Ding Luo and Li Li

    Citation: Cancer Cell International 2017 17:118

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  5. Content type: Primary Research

    Chemoresistance of glioblastoma (GBM) is a feature of this devastating disease. This study is to determine the relationship between Hedgehog (HH)/Gli1 signaling pathway and chemoresistance to temozolomide (TMZ...

    Authors: Ke Wang, Dongjiang Chen, Zhouqi Qian, Daming Cui, Liang Gao and Meiqing Lou

    Citation: Cancer Cell International 2017 17:117

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  6. Content type: Primary Research

    Herein, for the first time, we report aberrant expression of membrane-associated RING-CH8 (MARCH8) in human esophageal squamous cell carcinoma. MARCH8 is a member of the recently discovered MARCH family of rea...

    Authors: Shivam Singh, Anoop Saraya, Prasenjit Das and Rinu Sharma

    Citation: Cancer Cell International 2017 17:116

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  7. Content type: Primary Research

    We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-κB) activity during the development of diabetic nephropathy in mice. NF-κB plays important roles in genesi...

    Authors: Chao-Yan Wu, Yuan Ke, Yi-Fei Zeng, Ying-Wen Zhang and Hai-Jun Yu

    Citation: Cancer Cell International 2017 17:115

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  8. Content type: Primary Research

    T lymphocytes play an indispensably important role in clearing virus and tumor antigen. There is little knowledge about impacts of inhibitory molecules with cytokine on tumor-infiltrating CD4+ T-cells in the pres...

    Authors: Long Yuan, Benling Xu, Peng Yuan, Jinxue Zhou, Peng Qin, Lu Han, Guangyu Chen, Zhenlei Wang, Zengci Run, Peng Zhao and Quanli Gao

    Citation: Cancer Cell International 2017 17:114

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  9. Content type: Primary Research

    Human chemokine like factor (CKLF)-like MAL and related proteins for vesicle trafficking transmembrane, domain-containing member 5 (CMTM5) has been shown to involved and may function as a tumour suppressor in ...

    Authors: Gang Xu and Chengxue Dang

    Citation: Cancer Cell International 2017 17:113

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  10. Content type: Primary Research

    RAC3 coactivator overexpression has been implicated in tumorigenesis, contributing to inhibition of apoptosis and autophagy. Both mechanisms are involved in resistance to treatment with chemotherapeutic agents...

    Authors: María Fernanda Rubio, María Cecilia Lira, Francisco Damián Rosa, Adrían Dario Sambresqui, María Cecilia Salazar Güemes and Mónica Alejandra Costas

    Citation: Cancer Cell International 2017 17:111

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  11. Content type: Review

    Recent studies suggested that natural compounds are important in finding targets for cancer treatments. Autophagy (“self-eating”) plays important roles in multiple diseases and acts as a tumor suppressor in ca...

    Authors: Eun Jung Sohn and Hwan Tae Park

    Citation: Cancer Cell International 2017 17:110

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  12. Content type: Primary Research

    Bmi1 (B lymphoma Mo-MLV insertion region 1 homolog) contributes to human tumorigenesis via epigenetic transcriptional silencing and represents a novel therapeutic target with great potentials. Here we sought t...

    Authors: Qiong Wang, Zhongwu Li, Yaping Wu, Rong Huang, Yumin Zhu, Wei Zhang, Yanling Wang and Jie Cheng

    Citation: Cancer Cell International 2017 17:107

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  13. Content type: Primary Research

    Human mucoepidermoid carcinoma (MEC) is regarded as the most common primary salivary malignancy. High-grade MEC has a high risk of recurrence and poor prognosis. Tumor angiogenesis, induced by poorly different...

    Authors: Sen Yang and Li-Juan Guo

    Citation: Cancer Cell International 2017 17:106

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  14. Content type: Primary Research

    Gastric cancer ranks 4th among the most common cancers worldwide, and the mortality caused by gastric cancer is 2nd only to lung cancer. Gastric cancer shows a lack of specific symptoms in its early stages. In...

    Authors: Hongshuang Tong, Yue Wang, Yue Li, Shujuan Liu, Chunjie Chi, Desheng Liu, Lei Guo, Enyou Li and Changsong Wang

    Citation: Cancer Cell International 2017 17:108

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  15. Content type: Primary Research

    Recent studies showed that long non-coding RNA (lncRNA) plays an important role in many life activities. RPPH1 is one of the lncRNA genes that are expressed differently between breast cancer and normal tissues by...

    Authors: Yi Zhang and Lili Tang

    Citation: Cancer Cell International 2017 17:109

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  16. Content type: Primary Research

    Glioblastoma multiforme (GBM) is known as one of the most fatal forms of cancer. MicroRNAs have been widely implicated in the regulation of mammalian development and pathogenesis. The brain-enriched miR-29 sub...

    Authors: Jaekyung Shin, Hyun Geun Shim, Taeyoung Hwang, Hyungsin Kim, Shin-Hyuk Kang, Yun-Sik Dho, Sung-Hye Park, Sang Jeong Kim and Chul-Kee Park

    Citation: Cancer Cell International 2017 17:104

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  17. Content type: Primary Research

    MiRNAs are vital in functioning as either oncogenes or tumor suppressors in the cell cycle. Target transcripts for immune checkpoint molecules such as PD-1/PD-L1 and (programmed cell death-1/its ligand and cyt...

    Authors: Laura Boldrini, Mirella Giordano, Cristina Niccoli, Franca Melfi, Marco Lucchi, Alfredo Mussi and Gabriella Fontanini

    Citation: Cancer Cell International 2017 17:105

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  18. Content type: Primary research

    Renal cell carcinoma (RCC) is the most common kidney cancer, accounting for approximately 80–90% of all primary kidney cancer. Treatment for patients with advanced RCC remains unsatisfactory. Rare cancer stem ...

    Authors: Du-Chu Chen, You-De Liang, Liang Peng, Yi-Ze Wang, Chun-Zhi Ai, Xin-Xing Zhu, Ya-Wei Yan, Yasmeen Saeed, Bin Yu, Jingying Huang, Yuxin Gao, Jiaqi Liu, Yi-Zhou Jiang, Min Liu and Demeng Chen

    Citation: Cancer Cell International 2017 17:103

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  19. Content type: Primary Research

    MicroRNAs are considered as potential regulators in various biological pathways and contribute to the diagnosis and prognosis of cancers. MicroRNA-214-3p (miR-214-3p) was proved to be correlated with various c...

    Authors: Yue Li, You Li, Yao Chen, Qian Xie, Ningning Dong, Yanjun Gao, Huan Deng, Chunhua Lu and Suihai Wang

    Citation: Cancer Cell International 2017 17:102

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  20. Content type: Review

    Cancer stem cells (CSCs) are rare but accounted for tumor initiation, progression, metastasis, relapse and therapeutic resistance. Ubiquitination and deubiquitination of stemness-related proteins are essential...

    Authors: Hu Lei, Huizhuang Shan and Yingli Wu

    Citation: Cancer Cell International 2017 17:101

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  21. Content type: Primary Research

    As one of the hallmarks of cancer, chemoresistance hinders curative cancer chemotherapy in osteosarcoma (OS). MicroRNAs (miRNAs) act as key regulators of gene expression in diverse biological processes includi...

    Authors: Fangfang Zhao, Youguang Pu, Mingda Cui, Haiyan Wang and Shanbao Cai

    Citation: Cancer Cell International 2017 17:100

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  22. Content type: Correction

    Upon publication of the original article [1], it was noticed that corresponding author status has been erroneously attributed to José Antonio Fagundes Assumpção. The corresponding author of this manuscript should...

    Authors: José Antonio Fagundes Assumpção, Kelly Grace Magalhães and José Raimundo Corrêa

    Citation: Cancer Cell International 2017 17:99

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    The original article was published in Cancer Cell International 2017 17:82

  23. Content type: Review

    Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-re...

    Authors: Lisa Repsold, Roger Pool, Mohammed Karodia, Gregory Tintinger and Annie Margaretha Joubert

    Citation: Cancer Cell International 2017 17:89

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  24. Content type: Primary Research

    More than 400,000 patients die from esophageal cancer annually. Considerable efforts have been made to develop new and effective treatments, one of which is directed toward herbal medication. Crocetin is a nat...

    Authors: Sheng Li, Xiu-Yin Shen, Ting Ouyang, Yuhua Qu, Tao Luo and Hua-Qiao Wang

    Citation: Cancer Cell International 2017 17:98

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