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  1. Dysregulation of circular RNAs (circRNAs) has recently been found to play an important role in the progression and development of cancers such as non-small cell lung cancer (NSCLC). Yet the functions of many c...

    Authors: Mingming Jin, Xiyu Liu, Yue Wu, Yuqing Lou, Xue Li and Gang Huang
    Citation: Cancer Cell International 2022 22:219
  2. Protein disulphide isomerases (PDIs) play an important role in cancer progression. However, the relative contribution of the various isoforms of PDI in tumorigenesis is not clear.

    Authors: Anna Kurpińska, Joanna Suraj-Prażmowska, Marta Stojak, Joanna Jarosz, Łukasz Mateuszuk, Ewa Niedzielska-Andres, Magdalena Smolik, Joanna Wietrzyk, Ivars Kalvins, Maria Walczak and Stefan Chłopicki
    Citation: Cancer Cell International 2022 22:218
  3. The oncogenic role of doublecortin-like kinase 1 (DCLK1) as a putative cancer stem cell (CSC) marker has been clarified in colorectal cancer (CRC). Isoform-specific functions of DCLK1 have shed new light on di...

    Authors: Elham Kalantari, Mahdieh Razmi, Fatemeh Tajik, Mohsen Asadi-Lari, Roya Ghods and Zahra Madjd
    Citation: Cancer Cell International 2022 22:217
  4. Colorectal cancer (CRC) with pulmonary metastasis usually indicates a poor prognosis, whereas patients may benefit from adoptive cell therapy. Tumor-specific cytotoxic T lymphocytes (CTLs) have been reported a...

    Authors: Juan Zhang, Lei Wang, Shuyi Li, Xuefeng Gao and Zhong Liu
    Citation: Cancer Cell International 2022 22:216
  5. MIR4435-2HG (LINC00978) is a long non-coding RNA (lncRNA) that acts as an oncogene in almost all cancers. This lncRNA participates in the molecular cascades involved in other disorders such as coronary artery dis...

    Authors: Majid Ghasemian, Masoumeh Rajabibazl, Unes Sahebi, Samira Sadeghi, Reza Maleki, Veys Hashemnia and Reza Mirfakhraie
    Citation: Cancer Cell International 2022 22:215
  6. Esophageal squamous cell carcinoma (ESCC) is the leading cause of cancer-related death worldwide with a poor prognosis. Given that DEPDC1B plays a key role in multiple cancers, the role of this molecule in ESC...

    Authors: Yunfeng Yuan, Wei Ping, Ruijie Zhang, Zhipeng Hao and Ni Zhang
    Citation: Cancer Cell International 2022 22:214
  7. Thrombospondin-2 (THBS2) is a versatile glycoprotein that regulates numerous biological functions, including the apoptosis-proliferation balance in endothelial cells, and it has been linked to tumor angiogenes...

    Authors: Xingchen Liao, Wei Wang, Baoping Yu and Shiyun Tan
    Citation: Cancer Cell International 2022 22:213
  8. Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca2+/calcineurin signaling. Recently, it is reported that aberrantly activated NFATc4 part...

    Authors: Qiu-Hua Zhong, Si-Wei Zha, Andy T. Y. Lau and Yan-Ming Xu
    Citation: Cancer Cell International 2022 22:212
  9. Studies over the past decade have shown that competitive endogenous RNA (ceRNA) plays an essential role in the tumorigenesis and progression of clear cell renal cell carcinoma (ccRCC). Meanwhile, immune checkp...

    Authors: Yankang Cui, Tianyi Shen, Feng Xu, Jing Zhang, Yuhao Wang, Jiajin Wu, Hengtao Bu, Dian Fu, Bo Fang, Huichen Lv, Suchun Wang, Changjie Shi, Bianjiang Liu, Haowei He, Hao Tang and Jingping Ge
    Citation: Cancer Cell International 2022 22:211
  10. Colorectal cancer (CRC) is the third cause of cancer death in the world that arises from the glandular and epithelial cells of the large intestine, during a series of genetic or epigenetic alternations. Recent...

    Authors: Shirin Azizidoost, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Riyadh Ahmad Ali, Maryam Cheraghzadeh and Maryam Farzaneh
    Citation: Cancer Cell International 2022 22:209
  11. Radiotherapy is a powerful and widely used technique for the treatment of solid tumors. Beyond its ability to destroy tumor cells, it has been demonstrated that radiotherapy can stimulate the anti-tumor immune...

    Authors: Audrey Darmon, Ping Zhang, Julie Marill, Naeemunnisa Mohamed Anesary, Jordan Da silva and Sébastien Paris
    Citation: Cancer Cell International 2022 22:208
  12. PTENP1 is a long non-coding RNA which has been regarded as a pseudogene of the PTEN tumor suppressor gene. However, it has been shown to be a biologically active transcript that can function as a competing endoge...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri and Nader Akbari Dilmaghani
    Citation: Cancer Cell International 2022 22:207
  13. Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not o...

    Authors: Praveen Dhyani, Cristina Quispe, Eshita Sharma, Amit Bahukhandi, Priyanka Sati, Dharam Chand Attri, Agnieszka Szopa, Javad Sharifi-Rad, Anca Oana Docea, Ileana Mardare, Daniela Calina and William C. Cho
    Citation: Cancer Cell International 2022 22:206
  14. Colorectal cancer (CRC) is one of the three major cancers in the world and is the cancer with the most liver metastasis. The present study aimed to investigate the role of metallothionein 2A (MT2A) in the modu...

    Authors: Xi Liu, Jun Quan, Zhaolong Shen, Zequn Zhang, Zhijian Chen, Liang Li, Xiaorong Li, Gui Hu and Xiaofeng Deng
    Citation: Cancer Cell International 2022 22:205
  15. Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by the lack of estrogen receptor, progesterone receptor, and HER2. Our lab previously characterized miR-3189-3p as a...

    Authors: Cecilia Vittori, Duane Jeansonne, Hassan Yousefi, Celeste Faia, Zhen Lin, Krzysztof Reiss and Francesca Peruzzi
    Citation: Cancer Cell International 2022 22:204
  16. Ubiquitination is a basic post-translational modification of intracellular proteins and can be reversed enzymatically by DUBs (deubiquitinating enzymes). More than 90 DUBs have been identified. Among them, the...

    Authors: Zhishuo Zhang, Wenxia Zhao, Yiming Li, Yang Li, Hanzeng Cheng, Liyun Zheng, Xiaoyu Sun, Hao Liu and Rongguang Shao
    Citation: Cancer Cell International 2022 22:203
  17. Breast cancer is the most common malignancy affecting women, yet effective targets and related candidate compounds for breast cancer treatment are still lacking. The lipogenic enzyme, stearoyl-CoA desaturase-1...

    Authors: Chen Yang, Yi-Yuan Jin, Jie Mei, Die Hu, Xiaoyu Jiao, Hui-Lian Che, Chun-Lei Tang, Yan Zhang and Guo-Sheng Wu
    Citation: Cancer Cell International 2022 22:202
  18. Phosphoglucomutase 1 (PGM1) is known for its involvement in cancer pathogenesis. However, its biological role in colorectal cancer (CRC) has remained unknown. Here, we studied the functions and mechanisms of P...

    Authors: Zhewen Zheng, Xue Zhang, Jian Bai, Long Long, Di Liu and Yunfeng Zhou
    Citation: Cancer Cell International 2022 22:201
  19. Cancer can be induced by a variety of possible causes, including tumor suppressor gene failure and proto-oncogene hyperactivation. Tumor-associated extrachromosomal circular DNA has been proposed to endanger h...

    Authors: Mohsen Karami Fath, Nastaran Karimfar, Andarz Fazlollahpour Naghibi, Shahriyar Shafa, Melika Ghasemi Shiran, Mehran Ataei, Hossein Dehghanzadeh, Mohsen Nabi Afjadi, Tahereh Ghadiri, Zahra Payandeh and Vahideh Tarhriz
    Citation: Cancer Cell International 2022 22:200
  20. Several studies have revealed that N6-methyladenosine (m6A) regulation is involved in various biological processes and cancer progression. Nevertheless, the potential effects of m6A modifications in the tumor ...

    Authors: Hao Xu, Lu Yin, Qianhui Xu, Jingjing Xiang and Rujun Xu
    Citation: Cancer Cell International 2022 22:199
  21. Non-small cell lung cancer (NSCLC), the most primary lung cancer subtype, threatens human health globally. Long non-coding RNAs (lncRNAs) have been uncovered to affect multiple cancers progression. Nevertheles...

    Authors: Shangxiao Huang, Shixiong Liang, Jianfeng Huang, Penghui Luo, Dunchang Mo and Hanlei Wang
    Citation: Cancer Cell International 2022 22:198
  22. This study aims to clarify the mechanistic action of long non-coding RNA (lncRNA) SNHG12 in the development of renal cell carcinoma (RCC), which may be associated with promoter methylation modification by KMT2...

    Authors: Jia-fu Feng, Jun Wang, Gang Xie, Yao-dong Wang, Xiao-han Li, Wen-yu Yang, Yu-wei Yang and Bin Zhang
    Citation: Cancer Cell International 2022 22:197
  23. Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and morality rate are rising and poses an important threat to the public health. It is known that multiple drug resistance (...

    Authors: Masoumeh Sharifi-Azad, Marziyeh Fathi, William C. Cho, Abolfazl Barzegari, Hamed Dadashi, Mehdi Dadashpour and Rana Jahanban-Esfahlan
    Citation: Cancer Cell International 2022 22:196
  24. Arsenic trioxide (ATO) is highly effective in acute promyelocytic leukemia (APL) patients, but it fails to show satisfactory efficacy in other acute myeloid leukemia (AML) patients with non-APL subtypes. Diffe...

    Authors: Wanbin Fu, Gelan Zhu, Lan Xu, Jia Liu, Xiaofeng Han, Junying Wang, Xinpeng Wang, Jian Hou, Huanbin Zhao and Hua Zhong
    Citation: Cancer Cell International 2022 22:195
  25. DANCR is an RNA gene located on chr4. This gene has several splice variants. Up-regulation of DANCR has been reported in many types of cancers. This lncRNA is mainly located in the cytoplasm and regulates genes e...

    Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Aria Baniahmad, Mohammad Taheri and Mohammad Samadian
    Citation: Cancer Cell International 2022 22:194
  26. To screen and verify differential genes affecting the prognosis of breast cancer.

    Authors: Yu Xiao, Zhiqin Deng, Yongshen Li, Baoting Wei, Xiaoqiang Chen, Zhe Zhao, Yingjie Xiu, Meifang Hu, Murad Alahdal, Zhenhan Deng, Daping Wang, Jianquan Liu and Wencui Li
    Citation: Cancer Cell International 2022 22:193
  27. In hepatocellular carcinoma (HCC), histone deacetylases (HDACs) are frequently overexpressed. This results in chromatin compaction and silencing of tumor-relevant genes and microRNAs. Modulation of microRNA ex...

    Authors: Nicole Huge, Thea Reinkens, Reena Buurman, Maria Sandbothe, Anke Bergmann, Hannah Wallaschek, Beate Vajen, Amelie Stalke, Melanie Decker, Marlies Eilers, Vera Schäffer, Oliver Dittrich-Breiholz, Engin Gürlevik, Florian Kühnel, Brigitte Schlegelberger, Thomas Illig…
    Citation: Cancer Cell International 2022 22:192
  28. Deacetylation of histones by histone deacetylase 3 (HDAC3) acts importantly in modulating apoptosis, DNA damage and cellular progression. Herein, we aimed to unravel the functional role of HDAC3 in a lethal di...

    Authors: Yang Yang, Yuan Zhang, Zongxiang Lin, Kai Wu, Zhanfeng He, Dengyan Zhu, Jia Zhao, Chunyang Zhang and Yuxia Fan
    Citation: Cancer Cell International 2022 22:191
  29. Extracellular vesicles secreted by tumor microenvironment (TME) cells are vital players in tumor progression through transferring nucleic acids and proteins. Macrophages are the main immune cells in TME and tu...

    Authors: Wen-Xiu Xu, Dan-Dan Wang, Zhi-Qiang Zhao, He-Da Zhang, Su-Jin Yang, Qian Zhang, Lei Li and Jian Zhang
    Citation: Cancer Cell International 2022 22:190
  30. Inositol Polyphosphate-5-Phosphatase B (INPP5B), a inositol 5-phosphatase, plays an important role in many biological processes through phosphorylating PI(4,5)P2 and/or PI(3,4,5)P3 at the 5-position. Nevertheless...

    Authors: Jun Deng, Xu Lin, Qi Li, Xiao-yu Cai, Lin-wen Wu, Wei Wang, Bo Zhang, Yang-ling Li, Jian Hu and Neng-ming Lin
    Citation: Cancer Cell International 2022 22:189
  31. Anillin (ANLN) is an actin-binding protein that is essential for cell division and contributes to cell growth and migration. Although previous studies have shown that ANLN is related to carcinogenesis, no pan-...

    Authors: Yanlong Shi, Xinyu Ma, Menglu Wang, Sheng Lan, Haokun Jian, Yue Wang, Qian Wei and Fei Zhong
    Citation: Cancer Cell International 2022 22:188
  32. The interaction between tumor cells and tumor microenvironment (TME) has an important impact on progression and prognosis of multiple myeloma (MM), and has been proven to be promising therapeutic targets. This...

    Authors: Huizhong Wang, Ruonan Shao, Wenjian Liu, Shumei Peng, Shenrui Bai, Bibo Fu, Congling Zhao and Yue Lu
    Citation: Cancer Cell International 2022 22:187
  33. Immune checkpoint inhibitors (ICIs) have made important breakthrough in anti-tumor therapy, however, no single biomarker can accurately predict their efficacy. Studies have found that tumor microenvironment is...

    Authors: Wenqin Feng, Anqi Lin, Le Sun, Ting Wei, Haoxuan Ying, Jian Zhang, Peng Luo and Weiliang Zhu
    Citation: Cancer Cell International 2022 22:186
  34. Papillary thyroid carcinoma (PTC), the most common endocrine cancer, accounts for 80–85% of all malignant thyroid tumors. This study focused on identifying targets that affect the multifocality of PTC. In a pr...

    Authors: Ga Hyun Kim, Hye Jin Heo, Ji Wan Kang, Eun-Kyung Kim, Seung Eun Baek, Keunyoung Kim, In Joo Kim, Sunghwan Suh, Byung-Joo Lee, Yun Hak Kim and Kyoungjune Pak
    Citation: Cancer Cell International 2022 22:185
  35. Breast cancer (BC) is one of the most prevalent malignancies among women globally. Emerging evidence indicates that long non-coding RNAs (lncRNAs) are associated with BC carcinogenesis. In the current study, w...

    Authors: Congjing An, Zhigang Hu, Yuehong Li, Pengxin Zhao, Runtian Liu, Qing Zhang, Peiling Zhu, Yanting Li and Ying Wang
    Citation: Cancer Cell International 2022 22:184
  36. Tetraspanins are members of the 4-transmembrane protein superfamily (TM4SF) that function by recruiting many cell surface receptors and signaling proteins into tetraspanin-enriched microdomains (TEMs) that pla...

    Authors: Shijie Shao, Lianhua Piao, Liwei Guo, Jiangsong Wang, Luhui Wang, Jiawen Wang, Lei Tong, Xiaofeng Yuan, Junke Zhu, Sheng Fang and Yimin Wang
    Citation: Cancer Cell International 2022 22:183
  37. Long noncoding RNAs (lncRNAs) are emerging as master regulators for gene expression and thus play a vital role in human tumorigenesis and progression. But the involvement of novel lncRNAs in non-small cell lun...

    Authors: Wei Gong, Yinyan Li, Jianfeng Xian, Lei Yang, Yuanyuan Wang, Xin Zhang, Yifeng Zhou, Xinhua Wang, Guibin Qiao, Cuiyi Chen, Soham Datta, Xincheng Gao, Jiachun Lu and Fuman Qiu
    Citation: Cancer Cell International 2022 22:181
  38. Immunodeficiencies are genetic diseases known to predispose an individual to cancer owing to defective immunity towards malignant cells. However, the link between immunodeficiency and prostate cancer progressi...

    Authors: Chia-Yang Li, Shu-Pin Huang, Yei-Tsung Chen, Hsin-En Wu, Wei-Chung Cheng, Chao-Yuan Huang, Chia-Cheng Yu, Victor C. Lin, Jiun-Hung Geng, Te-Ling Lu and Bo-Ying Bao
    Citation: Cancer Cell International 2022 22:180
  39. Zinc finger and BTB domain-containing 7A (ZBTB7A) is a member of the POK family of transcription factors that plays an oncogenic or tumor-suppressive role in different cancers depending on the type and genetic...

    Authors: Junqiang Liu, Zhiyuan Chou, Chun Li, Kai Huang, Xuejian Wang, Xiunan Li, Chuanchun Han, Abdullah Al-Danakh, Xiaodong Li and Xishuang Song
    Citation: Cancer Cell International 2022 22:179
  40. Breast cancer is notorious for its increasing incidence for decades. Ascending evidence has demonstrated that translocase of inner mitochondrial membrane (TIMM) proteins play vital roles in progression of seve...

    Authors: Zhonglin Wang, Shuqin Li, Feng Xu, Jingyue Fu, Jie Sun, XinLi Gan, Chuang Yang and Zhongqi Mao
    Citation: Cancer Cell International 2022 22:177
  41. Malignant mesothelioma (MMe) is an aggressive neoplasm that occurs through the transformation of mesothelial cells. Asbestos exposure is the main risk factor for MMe carcinogenesis. Other important etiologies ...

    Authors: Faezeh Malakoti, Niloufar Targhazeh, Erfan Abadifard, Reza Zarezadeh, Sahar Samemaleki, Zatollah Asemi, Simin Younesi, Reza Mohammadnejad, Seyed Hadi Hossini, Ansar Karimian, Forough Alemi and Bahman Yousefi
    Citation: Cancer Cell International 2022 22:176
  42. Epithelial ovarian cancer (EOC) is an aggressive and lethal malignancy and novel EOC cell lines with detailed characterization are needed, to provide researchers with diverse helpful resources to study EOC bio...

    Authors: Fernanda Silva, Filipa Coelho, Ana Peixoto, Pedro Pinto, Carmo Martins, Ann-Sophie Frombach, Vítor E. Santo, Catarina Brito, António Guimarães and Ana Félix
    Citation: Cancer Cell International 2022 22:175
  43. FGFR1 regulates cell–cell adhesion and extracellular matrix architecture and acts as oncogene in several cancers. Potential cancer driver mutations of FGFR1 occur in neuroblastoma (NB), a neural crest-derived ped...

    Authors: Flora Cimmino, Annalaura Montella, Matilde Tirelli, Marianna Avitabile, Vito Alessandro Lasorsa, Feliciano Visconte, Sueva Cantalupo, Teresa Maiorino, Biagio De Angelis, Martina Morini, Aurora Castellano, Franco Locatelli, Mario Capasso and Achille Iolascon
    Citation: Cancer Cell International 2022 22:174
  44. G-quadruplexes are secondary helical configurations established between guanine-rich nucleic acids. The structure is seen in the promoter regions of numerous genes under certain situations. Predicted G-quadrup...

    Authors: Soudeh Ghafouri-Fard, Atefe Abak, Aria Baniahmad, Bashdar Mahmud Hussen, Mohammad Taheri, Elena Jamali and Marcel E. Dinger
    Citation: Cancer Cell International 2022 22:171
  45. Gliomas are the most common primary malignant tumours of the central nervous system (CNS). To improve the prognosis of glioma, it is necessary to identify molecular markers that may be useful for glioma therap...

    Authors: Hui Huang, Zhengyuan Huo, Jiantong Jiao, Wei Ji, Jin Huang, Zheng Bian, Bin Xu, Junfei Shao and Jun Sun
    Citation: Cancer Cell International 2022 22:170
  46. Chondrogenesis is the formation of chondrocytes and cartilage tissues and starts with mesenchymal stem cell (MSC) recruitment and migration, condensation of progenitors, chondrocyte differentiation, and matura...

    Authors: Xiaohui Yang, Shifeng Tian, Linlin Fan, Rui Niu, Man Yan, Shuo Chen, Minying Zheng and Shiwu Zhang
    Citation: Cancer Cell International 2022 22:169

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