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Cancer Cell International

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Featured article: miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1

Colon cancermiRNAs are regarded as molecular biomarkers and therapeutic targets for colorectal cancer (CRC). However, the function and underlying mechanism of miR-422a in the progression of CRC remain largely unknown. In this study, Wei et al. report that miR-422a is down‑regulated in CRC tissues and cell lines and inhibits cell proliferation in CRC by targeting AKT1 and MAPK1.

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  1. Content type: Primary Research


    Authors: Nicolette M. Clark, Carlos A. Garcia Galindo, Vandan K. Patel, Michele L. Parry, Rebecca J. Stoll, John M. Yavorski, Elizabeth P. Pinkason, Edna M. Johnson, Chelsea M. Walker, Joseph Johnson, Wade J. Sexton, Domenico Coppola and George Blanck

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Aims and scope

Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques.

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Y Eugene Chin, Shanghai Institute of Biological Sciences, China
Domenico Coppola, Moffitt Cancer Center, USA

Featured: Inhibition of breast cancer cell proliferation and tumorigenesis

Breast cancerRPPH1 is one of the lncRNA genes that are expressed differently between breast cancer and normal tissues. Some lncRNA genes have been reported to play an important role in the occurrence and development of breast cancer. This study, by Zhang and Tang, was conducted in order to examine the regulation of lncRNA RPPH1 in breast cancer.


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