Featured article: Dual EGFR and BRAF blockade overcomes resistance to vemurafenib in BRAF mutated TC cells

Thyroid Cancer. Credit: Darryl Leja, NHGRI.In this study, Notarangelo et al., evaluated the hypothesis that the exposure of BRAF-mutated thyroid carcinoma (TC) cells to vemurafenib results in EGFR feedback activation and that dual EGFR and BRAF blockade is superior to single agents. 

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Aims and scope

Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques.

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Featured article: DMD transcripts in CRL-2061 RMS cells show high levels of intron retention

DMDThe DMD gene encoding dystrophin is mutated in Duchenne muscular dystrophy and has been shown to act as a tumor suppressor. Rhabdomyosarcoma (RMS) is a mesodermal sarcoma that shares characteristics of skeletal muscle precursors. In this article, Niba et al., analyze DMD products in CRL-2061 cells established from alveolar rhabdomyosarcoma.

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