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Table 1 Summary of mutation detection.

From: A cancer derived mutation in the Retinoblastoma gene with a distinct defect for LXCXE dependent interactions

  Blood samples Tumor samples
    Breast Ovarian
  Screened Mutations Screened Mutations Screened Mutations
Exon 21 627 0 50 0 21 0
Exon 22 627 0 50 0 21 0
Exon 23 627 0 50 0 21 0
  1. To detect heterozygous sequence changes, peripheral blood samples from breast and/or ovarian cancer patients were subjected to HRM analysis using primers specific to exons 21, 22 and 23. To detect potentially homozygous sequence changes from breast and ovarian tumor samples, PCR amplicons of these exons were directly sequenced.