Dz13 inhibits OS metastasis from the bone efficaciously. Dz13 efficacy was next tested in the SaOS-2 orthotopic model. Dz13 was able to reduce OS metastasis to the lung after treatment was administered when tumours were palpable. Both macrometastasis (A) and micrometastasis (B) counts were reduced in the Dz13 cohort. (C) Histology confirmed that there were less micrometastases in lungs of mice in the Dz13 cohort (middle) compared to untreated (top) and Scr-treated (bottom). (D) Primary tumour was not affected by the treatments administered.