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Table 1 Characteristics of the four PCA clusters(p1-p4)

From: A 6-gene signature identifies four molecular subgroups of neuroblastoma

Fisher's exact test p1 p2 p3 p4   
  Data set 1
(n = 4)
Data set 2
(n = 10)
Data set 1
(n = 4)
Data set 2
(n = 10)
Data set 1
(n = 6)
Data set 2
(n = 5)
Data set 1
(n = 3)
Data set 2
(n = 5)
  
High stage (3 or 4) 0,053* 0,056 0,330 0,691 0,075 0,355 0,324 1,000   
Stage 4 0,029* 0,001** 0,241 0,062 0,088 0,304 0,124 0,696   
Outcome 0,139 0,051* 0,555 1,000 0,072 1,000 0,728 0,070   
MNA 0,208 0,375 0,208 0,141 0,001** 0,003** 0,324 1,000   
Del1p 0,088 0,210 0,088 0,067 0,018* 3,9E-04** 0,360 0,589   
Del11q 0,441 0,235 0,559 0,013* 0,160 0,622 0,051* 0,622   
Gain17q 0,063 0,128 0,365 0,109 0,058 1,000 0,458 0,651   
ANOVA one-way ANOVA significance FC p1 FC p2 FC p3 FC p4
  Data set 1 Data set 2 Data set: 1 2 Data set: 1 2 Data set: 1 2 Data set: 1 2
ALK 1,1E-03** 0,277 -1,8 -0,5 1,2 0,0 3,6 1,4 -1,0 -0,6
BIRC5 6,1E-06** 1,4E-05** -2,9 -1,7 2,9 2,0 7,8 2,1 -3,0 -2,6
CCND1 0,011* 0,003** 0,5 1,1 2,0 0,4 1,0 0,1 -1,9 -2,6
MYCN 2,0E-04** 7,0E-04** -0,6 -0,3 0,4 -0,4 12,6 2,4 -3,5 -1,4
NTRK1 6,7E-04** 1,1E-05** 3,7 3,4 3,6 0,7 0,1 -4,0 -0,3 -2,6
PHOX2B 0,006** 3,4E-08** 0,5 0,6 2,0 1,0 1,2 0,7 -2,3 -3,2
  1. Fisher's exact test: Each cluster (p1, p2, p3, or p4) versus the other clusters combined. n = the number of samples in each subgroup. High stage = INSS stage 3 and 4; outcome = dead of disease; MNA = MYCN amplification; del = deletion. Significance is marked by stars: * p < 0.05, ** p < 0.01. ANOVA one-way: The differential expressions from six genes in PCA clusters (p1-p4) were tested by an ANOVA one-way test. Significance is marked by stars: * p < 0.05, ** p < 0.01. FC = The log2 fold change of genes in each PCA group compared to the other groups combined.