Table 4 Multivariate analysis of clinical factors affecting overall survival and event free survival of acute myeloid leukemia (AML) patients
From: Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF)
Variable | p | Hazard Ratio (CI) |
|---|---|---|
a) OVERALL SURVIVAL | ||
Age (continuous variable) | 0.315 | |
Gender (male/female) | 0.7822 | |
WBC (continuous variable) | 0.9718 | |
Chromosome 5 alterations | 0.0535 | |
Gata-1 expression (negative/positive) | 0.4750 | |
Gata-1 over-expression (zero-low/high) | 0.9489 | |
Gata-2 expression (negative/positive) | 0.4750 | |
Gata-2 over-expression (zer0-low/high) | 0.3677 | |
Eklf expression (negative/positive) | 0.0878 | |
Eklf over-expression (zero-low/high) | 0.0772 | |
cMPL epression (negative/positive) | 0.8023 | |
cMPL over-expression (zero-low/high) | 0.7546 | |
DIT-FLT3 (WT/mutated) | 0.283 | |
NPM1 mutations (no/yes) | 0.234 | |
Cytogenetic risk (intermediate/good) | 0.287 | |
Cytogenetic risk (adverse/good) | 0.139 | |
b) EVENT FREE SURVIVAL | ||
Age (continuous variable) | 0.6064 | |
Gender (male/female) | 0.9844 | |
WBC (continuous variable) | 0.757 | |
Chromosome 5 alterations | 0.6525 | |
Gata-1 expression (negative/positive) | 0.7682 | |
Gata-1 over-expression (zero-low/high) | 0.7405 | |
Gata-2 expression (negative/positive) | 0.9438 | |
Gata-2 over-expression (zero/low/high) | 0.3330 | |
Eklf expression (negative/positive) | 0.0385 | 0.4504 (0.2115-0.9589) |
Eklf over expression (zero-low/high) | 0.4693 | |
cMPL expression (negative/positive) | 0.4099 | |
cMPL over-expression (zero-low/high) | 0.8863 | |
DIT-FLT3 (WT/mutated) | 0.084 | |
NPM1 mutations (no/yes) | 0.120 | |
Cytogenetic risk (intermediate/good) | 0.704 | |
Cytogenetic risk (adverse/good) | 0.320 |