Figure 1

VSV Δ51 is lethal to FaDu cells  in vitro.  (A) FaDu Cells were visualized at 72 hrs post-infection with VSVΔ51 (0.1 pfu/cell) using light (middle) or fluorescence microscope (right) and compared to un-infected normal FaDu cells (left). (B) MTS assay for FaDu cell viability at 24, 48, and 72 hrs post-infection with the indicated doses of VSVΔ51 alone (left) or combined with 6 Gy IR (right) delivered just before infection. Data are presented as mean ± SD from representative experiments, n = 3. (C) Percent apoptosis (left panel) and fold increase in caspase 3 activity (right panel) in FaDu cells at 72 hrs post infection with 0.1 pfu/cell VSVΔ51. Data are presented as mean ± SE; n = 3 from two independent experiments.*p ≤ 0.05.