Quercetin-induced inhibition and synergistic activity with cisplatin – a chemotherapeutic strategy for nasopharyngeal carcinoma cells

Table 1 Description of CI values for each fraction of cells affected and the corresponding dose reduction index

NPC cell line	Fraction affected	CI	Description	Dose reduction index (DRI)
NPC cell line	Fraction affected	CI	Description	Quercetin	Cisplatin
HK1	0.395	0.474	Synergism	6.142	3.209
	0.881	0.239	Strong synergism	128.972	4.319
	0.943	0.338	Synergism	222.314	2.998
	0.991	0.308	Synergism	2055.870	3.247
C666-1	0.171	0.981	Nearly additive	1.936	2.153
	0.515	0.718	Moderate synergism	3.531	2.299
	0.772	0.735	Moderate synergism	4.412	1.967
	0.951	0.425	Synergism	11.690	2.944
	0.974	0.402	Synergism	14.736	2.994

DRI values > 1 are beneficial and the greater the DRI values, the greater the dose reduction for a given therapeutic effect [15].

ISSN: 1475-2867