Figure 1

Clinicopathological presentation of the brain tumor. The child patient: MRI images show that primary tumor diagnostics, resection, recurrence of a child glioblastoma patient during treatment of surgery, radiation, and chemotherapy (Yellow arrow: Tumor mass): a, pre-operation (sagittal view), showing the characteristic appearance of the tumor; b, Immediate postsurgery (sagittal), showing the removal of the tumor; c, 3-month post-surgery (sagittal), showing recurrence of the tumor; d, agarose gel electrophoretic analysis of CD133 expression using RT-PCR. The adult patient: Pre- and post-operative magnetic resonance imaging (MRI) shows hemorrhage and involvement of the lateral ventricle (e, f). e: Pre-operative MRI (Gadolinum-enhanced) of previous intracerebral hemorrhage (before tumor operation). f: Post-operative MRI. g: Pathology photomicrographs showed typical glioblastoma multiforme with nuclear atypia, endothelial proliferation, and necrosis (hematoxylin and eosin stain). Necrosis was seen with the pseudopalisading pattern of malignant cells. This is a high-grade glia neoplasm, characterized by variably cellular patternless sheets of polygonal and fusiform cells with moderate to marked nuclear atypia, amphophilic cytoplasm, prominent nucleoli, and many mitotic figures. Irregular zones of geographic necrosis were surrounded by palisading neoplastic cells. The tumor was vascular with many blood vessels lined by plump endothelial cells interspersed within the glial component. The cellular areas of the neoplasm are merged gradually with adjacent cerebral cortex. Neuronal satellitosis was seen in the transitional zone. These are consistent with glioblastoma multiforme involving intraventricular zone.