Table 1 Clinical features of the Patients with DMNT3A mutations
From: DNMT3A mutations and clinical features in Chinese patients with acute myeloid leukemia
No | Age | sex | FAB | Cytogenetics | WBC X10^9/L | CD33+/CD34+ | DNMT3A | Chemo-response | result |
|---|---|---|---|---|---|---|---|---|---|
7 | 65 | F | M1 | normal | 36.6 | 6%/92% | 2645 G > A | CR | Dead(12 M) |
19 | 72 | M | M2 | normal | 57.2 | 99%/32% | 914 G > A | No | Dead(6 M) |
22 | 55 | M | M5 | normal | 112.9 | 99%/16% | 2645 G > A | CR | Alive(SCT) |
38 | 58 | F | M5 | t(6;9) | 12.1 | 56%/55% | 2096 G > A | CR | Dead(10 M) |
40 | 56 | F | M2 | inv(9) | 15 | 20%/82% | 30 bp del 2502-2531 | CR | Dead(SCT) |
47 | 31 | F | M5 | del(13) | 1.5 | 95%/27% | 2501 C > T | N0 | Dead(3 M) |
48 | 20 | F | M5 | normal | 30.4 | 4.5%/71% | 2501 C > T | N0 | Dead(3 M) |
53 | 53 | F | M3 | t(4;17) | 7.9 | 82%/1.6% | 55 C > T | CR | Alive |
56 | 54 | F | M5 | normal | 2.19 | 95%/28% | 2202 C > A | CR | Relapse(6 M) |
68 | 52 | M | M5 | normal | 28.8 | 97%/42% | 2644 C > T | No | Dead(6 M) |
77 | 76 | M | M5 | normal | 67 | No | 2645 G > A Arg882His | CR | Dead(13 M) |
89 | 76 | M | M1 | normal | 17.3 | CD13 CD34 | 1906 G > A 2191 T > C | NR | Dead(3 M) |
94 | 61 | F | M5 | normal | 132 | CD7CD13CD33 | 2141C > G | NO | Dead(1 M) |
100 | 46 | M | M5 | normal | 4.5 | CD13CD34 | 1792C > T 2375 G > A | NR | Dead(1 M) |