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Table 2 Main results for the IL-8-251 A > T polymorphism with the risk of gastric carcinogenesis based on OR and 95% CI

From: Positive association between Interleukin-8 -251A > T polymorphism and susceptibility to gastric carcinogenesis: a meta-analysis

Genotype comparison OR [95% CI] Z (P value) Heterogeneity of study design Model
    χ2 I2  
Overall analysis (5,321 cases, 6,465 controls)      
A allele vs T allele 1.14 [1.02, 1.26] 2.33 (0.02) 59.55 71% Random
  Asian 1.20 [1.06, 1.36] 2.87 (<0.01) 29.42 66% Random
  Caucasian 0.95 [0.85, 1.07] 0.87 (0.38) 7.38 32% Random
AA vs AT + TT (dominant model) 1.17 [0.98, 1.38] 1.78 (0.07) 40.15 58% Random
  Asian 1.28 [1.02, 1.61] 2.11 (0.04) 24.53 59% Random
  Caucasian 0.92 [0.79, 1.08] 1.02 (0.31) 6.42 22% Fixed
AA + AT vs TT (recessive model) 1.18 [1.02, 1.36] 2.21 (0.03) 50.59 66% Random
  Asian 1.26 [1.08, 1.47] 2.86 (<0.01) 23.13 57% Random
  Caucasian 0.90 [0.78, 1.03] 1.53 (0.13) 5.29 70% Random
AA vs TT (homozygous comparison) 1.26 [1.02, 1.57] 2.10 (0.04) 52.95 6% Fixed
  Asian 1.40 [1.08, 1.83] 2.50 (0.01) 27.43 64% Random
  Caucasian 0.87 [0.73, 1.05] 1.48 (0.14) 7.62 34% Fixed
AT vs TT (heterozygous comparison) 1.14 [1.00, 1.31] 1.97 (0.05) 39.34 57% Random
  Asian 1.21 [1.09, 1.35] 3.55 (<0.01) 18.92 47% Random
  Caucasian 0.91 [0.78, 1.05] 1.29 (0.20) 3.64 0% Fixed
Gastric cancer analysis (4,513 cases, 6,465 controls)      
A allele vs T allele 1.15 [1.03, 1.29] 2.43 (0.02) 63.29 73% Random
  Asian 1.23 [1.07, 1.40] 2.94 (<0.01) 32.40 69% Random
  Caucasian 0.95 [0.84, 1.07] 0.85 (0.40) 7.46 33% Random
AA vs AT + TT (dominant model) 1.17 [0.98, 1.39] 1.75 (0.08) 40.38 58% Random
  Asian 1.28 [1.01, 1.63] 2.02 (0.04) 25.37 61% Random
  Caucasian 0.92 [0.79, 1.09] 0.95 (0.34) 6.31 21% Fixed
AA + AT vs TT (recessive model) 1.21 [1.03, 1.43] 2.36 (0.02) 58.32 71% Random
  Asian 1.32 [1.09, 1.59] 2.88 (<0.01) 29.51 66% Random
  Caucasian 0.90 [0.78, 1.03] 1.55 (0.12) 5.40 7% Fixed
AA vs TT (homozygous comparison) 1.29 [1.02, 1.62] 2.17 (0.03) 56.20 70% Random
  Asian 1.46 [1.09, 1.95] 2.52 (0.01) 30.52 67  Random
  Caucasian 0.87 [0.72, 1.05] 1.44 (0.15) 7.65 35 % Fixed
AT vs TT (heterozygous comparison) 1.18 [1.01, 1.38] 2.14 (0.03) 47.23 64% Random
  Asian 1.27 [1.06, 1.52] 2.57 (0.01) 25.47 61% Random
  Caucasian 0.90 [0.78, 1.05] 1.33 (0.18) 3.68 0% Fixed
Precancerous lesions analysis (808 cases, 1,288 controls)      
A allele vs T allele 1.09 [0.99, 1.20] 1.66 (0.08) 2.98 0% Fixed
AA vs AT + TT (dominant model) 1.15 [0.85, 1.56] 0.90 (0.37) 1.92 0% Fixed
AA + AT vs TT (recessive model) 1.21 [0.99, 1.49] 1.84 (0.07) 1.42 0% Fixed
AA vs TT (homozygous comparison) 1.27 [0.91, 1.76] 1.42 (0.16) 2.37 0% Fixed
AT vs TT (heterozygous comparison) 1.19 [0.96, 1.48] 1.59 (0.11) 0.69 0% Fixed
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