Table 2 Main results for the IL-8-251 A > T polymorphism with the risk of gastric carcinogenesis based on OR and 95% CI

Overall analysis (5,321 cases, 6,465 controls)

A allele vs T allele

1.14 [1.02, 1.26]

2.33 (0.02)

59.55

71%

Random

  Asian

1.20 [1.06, 1.36]

2.87 (<0.01)

29.42

66%

Random

  Caucasian

0.95 [0.85, 1.07]

0.87 (0.38)

7.38

32%

Random

AA vs AT + TT (dominant model)

1.17 [0.98, 1.38]

1.78 (0.07)

40.15

58%

Random

  Asian

1.28 [1.02, 1.61]

2.11 (0.04)

24.53

59%

Random

  Caucasian

0.92 [0.79, 1.08]

1.02 (0.31)

6.42

22%

Fixed

AA + AT vs TT (recessive model)

1.18 [1.02, 1.36]

2.21 (0.03)

50.59

66%

Random

  Asian

1.26 [1.08, 1.47]

2.86 (<0.01)

23.13

57%

Random

  Caucasian

0.90 [0.78, 1.03]

1.53 (0.13)

5.29

70%

Random

AA vs TT (homozygous comparison)

1.26 [1.02, 1.57]

2.10 (0.04)

52.95

6%

Fixed

  Asian

1.40 [1.08, 1.83]

2.50 (0.01)

27.43

64%

Random

  Caucasian

0.87 [0.73, 1.05]

1.48 (0.14)

7.62

34%

Fixed

AT vs TT (heterozygous comparison)

1.14 [1.00, 1.31]

1.97 (0.05)

39.34

57%

Random

  Asian

1.21 [1.09, 1.35]

3.55 (<0.01)

18.92

47%

Random

  Caucasian

0.91 [0.78, 1.05]

1.29 (0.20)

3.64

0%

Fixed

Gastric cancer analysis (4,513 cases, 6,465 controls)

A allele vs T allele

1.15 [1.03, 1.29]

2.43 (0.02)

63.29

73%

Random

  Asian

1.23 [1.07, 1.40]

2.94 (<0.01)

32.40

69%

Random

  Caucasian

0.95 [0.84, 1.07]

0.85 (0.40)

7.46

33%

Random

AA vs AT + TT (dominant model)

1.17 [0.98, 1.39]

1.75 (0.08)

40.38

58%

Random

  Asian

1.28 [1.01, 1.63]

2.02 (0.04)

25.37

61%

Random

  Caucasian

0.92 [0.79, 1.09]

0.95 (0.34)

6.31

21%

Fixed

AA + AT vs TT (recessive model)

1.21 [1.03, 1.43]

2.36 (0.02)

58.32

71%

Random

  Asian

1.32 [1.09, 1.59]

2.88 (<0.01)

29.51

66%

Random

  Caucasian

0.90 [0.78, 1.03]

1.55 (0.12)

5.40

7%

Fixed

AA vs TT (homozygous comparison)

1.29 [1.02, 1.62]

2.17 (0.03)

56.20

70%

Random

  Asian

1.46 [1.09, 1.95]

2.52 (0.01)

30.52

67 

Random

  Caucasian

0.87 [0.72, 1.05]

1.44 (0.15)

7.65

35 %

Fixed

AT vs TT (heterozygous comparison)

1.18 [1.01, 1.38]

2.14 (0.03)

47.23

64%

Random

  Asian

1.27 [1.06, 1.52]

2.57 (0.01)

25.47

61%

Random

  Caucasian

0.90 [0.78, 1.05]

1.33 (0.18)

3.68

0%

Fixed

Precancerous lesions analysis (808 cases, 1,288 controls)

A allele vs T allele

1.09 [0.99, 1.20]

1.66 (0.08)

2.98

0%

Fixed

AA vs AT + TT (dominant model)

1.15 [0.85, 1.56]

0.90 (0.37)

1.92

0%

Fixed

AA + AT vs TT (recessive model)

1.21 [0.99, 1.49]

1.84 (0.07)

1.42

0%

Fixed

AA vs TT (homozygous comparison)

1.27 [0.91, 1.76]

1.42 (0.16)

2.37

0%

Fixed

AT vs TT (heterozygous comparison)

1.19 [0.96, 1.48]

1.59 (0.11)

0.69

0%

Fixed