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Table 3 A summary of in vitro IC 50 of Flavokawain A, B, C in selected cancer cell lines

From: The flavokawains: uprising medicinal chalcones

Flavokawain Cancer cell lines IC50μM
Flavokawain A T24 ~17
RT4 ~17
EJ ~17
L-02 n.c.
HepG2 n.c.
Flavokawain B KB 20.05 ± 0.4
MCF-7 49.30 ± 1.8
Ca Ski 31.10 ± 1.3
HCT116 ~25
A549 ~25
HFW ~25
NIH3T3 ~25
MRC5 17.2 ± 0.5
T24 4.39-8.80
RT4 ~18
EJ ~9-18
LAPC4 32
LNCaP 48.3
PC-3 6.20
DU145 3.90
WPMY-1 2.25
22RV1 16.6
C4-2B 2.2
L-02 35.15 ± 2.56
HepG2 62.38 ± 5.04
HSC-3 ~18
Cal-27 ~27
A-2058 ~18
SYO ~9-18
HS-SY-II ~18-27
H460 18.2
ACC-2 4.69 ±0.43
T24 ~8-17
Flavokawain C RT4 ~1.5-17
EJ ~8.33
L-02 57.04 ± 2.32
HepG2 59.48 ± 2.72
  1. [6, 7, 19, 24, 25, 3335, 38, 40].
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