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Table 1 Comparative analysis of apoptosis in five different cancer cell lines assayed with PI staining followed by flow cytometry

From: Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani

Treatment IC50(μM) for apoptosis
  JR4-Jurkat HepG2 HeLa Ovcar3 T47D
TFUNG 0.006 ± 0.0003 0.1 ± 0.02 0.008 ± 0.001 0.2 ± 0.05 0.005 ± 0.001
BFUNG 3.5 ± 0.05 3 ± 0.1 4 ± 0.2 5 ± 0.3 2 ± 0.3
  1. JR4-Jurkat, HepG2, HeLa, Ovcar3 or T47D cell lines were treated with either fungal taxol (TFUNG) (0.001-5 μM) or fungal baccatin III (BFUNG) (0.001-8 μM) for 48 h prior to DNA histogram analysis by flow cytometry. The IC50 shown were calculated using values derived from the respective histograms. The results show the mean ± SD of three independent experiments.
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