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Table 2 Analysis of LAK cytotoxic activity toward H22 cells (mean ± SEM, n = 8)

From: Downregulation of the H-2Kd gene by siRNA affects the cytotoxicity of murine LAK cells

Experimental group Effector/target cell ratio
10:1 20:1 30:1 40:1
Control 28.6 ± 4.1 45.2 ± 4.8 68.4 ± 5.0 81.6 ± 5.9
siRNA-1 27.6 ± 2.1 40.6 ± 5.1*#▲ 55.4 ± 4.1*#▲ 65.0 ± 2.1*#▲
Mock-transfected 26.9 ± 5.6 46.9 ± 5.7 70.3 ± 6.0 80.5 ± 4.6
Non-silencing 30.3 ± 3.9 44.3 ± 3.8 67.0 ± 4.9 82.0 ± 2.6
  1. *P < 0.01, siRNA-transfected group compared with the control group;
  2. #P < 0.01, siRNA-transfected group compared with the mock-transfected group;
  3. P < 0.01, siRNA-transfected group compared with the non-silencing group.