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Table 3 Analysis of LAK cytotoxic activity toward K562 cells (mean ± SEM, n = 8)

From: Downregulation of the H-2Kd gene by siRNA affects the cytotoxicity of murine LAK cells

Experimental group Effector/target cell ratio
10:1 20:1 30:1 40:1
Control 30.1 ± 9.8 50.1 ± 6.4 63.4 ± 7.6 76.8 ± 5.8
siRNA-1 28.4 ± 36.9*#▲ 31.3 ± 6.5*#▲ 36.9 ± 5.9*#▲ 49.6 ± 7.7*#▲
Mock-transfected 28.9 ± 6.7 49.9 ± 5.8 66.3 ± 8.0 74.9 ± 8.1
Non-silencing 31.4 ± 8.7 51.2 ± 9.1 64.9 ± 8.9 80.0 ± 9.7
  1. *P < 0.01, siRNA-1-transfected group compared with the control group;
  2. #P < 0.01, siRNA-1-transfected group compared with the mock-transfected group;
  3. P < 0.01, siRNA-1-transfected group compared with the non-silencing group.