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Table 1 IC 50 values for primary and immortalized ovarian cancer cells upon drug treatment

From: Response to microtubule-interacting agents in primary epithelial ovarian cancer cells

 

Taxol

Epothilone B

Discodermolide

SS2

1.10 nM

0.05 nM

3.20 nM

SS3

0.19 nM

0.23 nM

1.14 nM

SS4

0.19 nM

0.15 nM

1.45 nM

SS5

0.17 nM

0.34 nM

1.18 nM

SS6

0.54 nM

2.51 nM

6.28 nM

SKOV3

10.0 nM

3.2 nM

52.1 nM

HEY

2.5 nM

0.9 nM

39.3 nM

  1. IC50 values were determined after 72 hours (for immortalized cells SKOV3 and HEY) and 12 days (for primary ovarian tumor cells) of incubation at 37°C with the indicated drugs. Concentration range for primary tumor cells: Taxol and EpoB: 0.1-50 nM, discodermolide: 0.2-100 nM; for Hey and SKOV3 cell lines: Taxol and EpoB: 0.5-250 nM; discodermolide: 1–500 nM.
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Cancer Cell International

ISSN: 1475-2867

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