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Table 1 IC 50 values for primary and immortalized ovarian cancer cells upon drug treatment

From: Response to microtubule-interacting agents in primary epithelial ovarian cancer cells

  Taxol Epothilone B Discodermolide
SS2 1.10 nM 0.05 nM 3.20 nM
SS3 0.19 nM 0.23 nM 1.14 nM
SS4 0.19 nM 0.15 nM 1.45 nM
SS5 0.17 nM 0.34 nM 1.18 nM
SS6 0.54 nM 2.51 nM 6.28 nM
SKOV3 10.0 nM 3.2 nM 52.1 nM
HEY 2.5 nM 0.9 nM 39.3 nM
  1. IC50 values were determined after 72 hours (for immortalized cells SKOV3 and HEY) and 12 days (for primary ovarian tumor cells) of incubation at 37°C with the indicated drugs. Concentration range for primary tumor cells: Taxol and EpoB: 0.1-50 nM, discodermolide: 0.2-100 nM; for Hey and SKOV3 cell lines: Taxol and EpoB: 0.5-250 nM; discodermolide: 1–500 nM.