Table 1 Differential cytotoxicity screening of paclitaxel and novel algal compounds against breast cancer and non-transformed breast epithelial cells in vitro

Compound

Structure

MDA-MB-231

MCF-7

MCF-12A

IC ₅₀ value

Concentration

Percentage survival

Paclitaxel

112.82 ± 5.22 nM

94.97 ± 1.10 nM

100 nM

69.40 ± 2.8%

Fucoxanthin

11.07 ± 0.56 μM

23.00 ± 0.01 μM

10 μM

71.32 ± 9.2%

RU017

Non-toxic

Non-toxic

300 μM

98.11 ± 4.6%

RU018

Non-toxic

Non-toxic

300 μM

95.15 ± 3.4%