Effects of HT and LY294002 on ADM and DDP induced cytotoxicity. WST-8 assay was used to detect survival rates of Raji cells in indicated groups. Cell viability were inhibited by ADM in a concentration-dependent manner. Raji cells in HT + ADM group (RH gropup) showed more resistant to ADM than ADM group (R group). When treated with LY294002 and ADM (RL group), Raji cells were more sensitive to ADM (A). Similar phenomenon was also observed when Raji cells were treated with DDP (B).