Activation of SSTR2 and ORs modulate PI3K/AKT cell survival pathway. Representative western blots illustrating the changes in the expression of PI3K (A) and AKT (B) in MCF-7, MDA-MB231 and T47D cells. Activation of SSTR2 and ORs individually or simultaneously exhibited no discernible changes in phosphorylation of PI3K and AKT, thus maintaining the status of PI3K/AKT at control levels. Bar graphs represent the densitometric analysis of PI3K/AKT expression in different tumor cells. The data presented are a representation of triplicate experiments.