Figure 1

Different subunits of protein complexes involved in basal in basal transcription have different enzymatic activities that are or can be target by drugs inhibiting RNPII transcription. In the case of BRD4, in addition to its kinase activity, the Brm domain is the target of JQ1 and I-BET151, which interferes with the binding to acetylated histones; therefore future drugs that target components of the basal transcription machinery could be designed to interfere the interaction between different subunits into the complex. The different subunits with enzymatic activities of a corresponding complex are indicated in the figure.