Significance of PRO2000/ANCCA expression, a novel proliferation-associated protein in hepatocellular carcinoma

Table 2 Univariate and multivariate analyses of potential prognostic factors associated with overall survival of HCC patients

Variables	Univariate analysis		Multivariate analysis
Variables	HR (95% CI)	P	HR (95% CI)	P
Gender (male/female)	1.128 (0.602-2.115)	0.707
Age (years) (≤51/>51)	2.305 (1.525-3.484)	<0.001	3.570 (2.311-5.516)	<0.001
Serum HBsAg (negative/positive)	0.822 (0.556-1.215)	0.326
Serum AFP (ng/ml) (≤20/>20)	0.945 (0.645-1.384)	0.772
Tumor size (cm) (≤5/>5)	1.410 (0.958-2.077)	0.082
Tumor number (single/multiple)	2.250 (1.422-3.559)	0.001	1.149 (0.300-4.403)	0.839
Tumor differentiation (I-II/III-IV)	7.922 (4.739-13.242)	<0.001	3.292 (1.563-6.937)	0.002
Cirrhosis (absent/present)	0.999 (0.679-1.471)	0.996
TNM stage (I-II/III-IV)	23.349 (11.008-49.527)	<0.001	3.848 (1.494-9.915)	0.005
Tumor microsatellite (absent/present)	1.877 (1.216-2.896)	0.004	1.404 (0.392-5.030)	0.602
Portal vein tumor thrombus (absent/present)	46.801 (16.166-135.495)	<0.001	11.741 (3.503-39.355)	<0.001
Recurrence (absent/present)	2.739 (1.628-4.609)	<0.001	1.220 (0.645-2.308)	0.541
ANCCA expression (−/+/++)	10.275 (6.440-16.395)	<0.001	8.745 (4.936-15.493)	<0.001

HR: hazard ratio, CI confidence interval. The P-value was calculated by Cox proportional hazards model.

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