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Table 2 Univariate and multivariate analyses of potential prognostic factors associated with overall survival of HCC patients

From: Significance of PRO2000/ANCCA expression, a novel proliferation-associated protein in hepatocellular carcinoma

Variables Univariate analysis Multivariate analysis
HR (95% CI) P HR (95% CI) P
Gender (male/female) 1.128 (0.602-2.115) 0.707   
Age (years) (≤51/>51) 2.305 (1.525-3.484) <0.001 3.570 (2.311-5.516) <0.001
Serum HBsAg (negative/positive) 0.822 (0.556-1.215) 0.326   
Serum AFP (ng/ml) (≤20/>20) 0.945 (0.645-1.384) 0.772   
Tumor size (cm) (≤5/>5) 1.410 (0.958-2.077) 0.082   
Tumor number (single/multiple) 2.250 (1.422-3.559) 0.001 1.149 (0.300-4.403) 0.839
Tumor differentiation (I-II/III-IV) 7.922 (4.739-13.242) <0.001 3.292 (1.563-6.937) 0.002
Cirrhosis (absent/present) 0.999 (0.679-1.471) 0.996   
TNM stage (I-II/III-IV) 23.349 (11.008-49.527) <0.001 3.848 (1.494-9.915) 0.005
Tumor microsatellite (absent/present) 1.877 (1.216-2.896) 0.004 1.404 (0.392-5.030) 0.602
Portal vein tumor thrombus (absent/present) 46.801 (16.166-135.495) <0.001 11.741 (3.503-39.355) <0.001
Recurrence (absent/present) 2.739 (1.628-4.609) <0.001 1.220 (0.645-2.308) 0.541
ANCCA expression (−/+/++) 10.275 (6.440-16.395) <0.001 8.745 (4.936-15.493) <0.001
  1. HR: hazard ratio, CI confidence interval. The P-value was calculated by Cox proportional hazards model.