Figure 2

The expression of PinX1 protein in normal prostate and PCa tissues by IHC on the TMA. (A) Positive expression of PinX1 in normal prostate tissue, in which about 100% of the prostate epithelial cells demonstrated a strong nuclear staining of PinX1, while a lesser staining in the cytoplasm could also be observed (100x). (B) Positive expression of PinX1 in PCa (case 21), in which more than 90% of tumor cells showed positive staining (100x). (C) Negative expression of PinX1 in PCa (case 11), with less than 40% positive tumor cells (100x). (D) Negative expression of PinX1 in PCa (case 27), with less than 35% positive tumor cells (100x). (E) Negative expression of PinX1 in PCa (case 25), with less than 15% positive tumor cells (100x). (F), (G), (H), (I) and (J) demonstrate the higher magnification (400x) from the area of black square in (A), (B), (C), (D) and (E), respectively.