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Figure 3 | Cancer Cell International

Figure 3

From: An estrogen analogue and promising anticancer agent refrains from inducing morphological damage and reactive oxygen species generation in erythrocytes, fibrin and platelets: a pilot study

Figure 3

Scanning electron microscopy images of control and ESE-16-treated fibrin networks, platelets and erythrocytes. The addition of thrombin to PRP resulted in the formation of fibrin networks (A - scale indicates 1 μm). Fibrin networks formed from ESE-16-treated PRP samples indicated normal fibrin morphology (B - scale indicates 1 μm). Control plasma smears to show platelet morphology (without thrombin) indicated normal morphology of platelets (C - scale indicates 1 μm) which corresponded with the morphology of ESE-16-treated platelets (D - scale indicates 2 μm) and is not similar to positive control DMSO-treated platelets which clearly reveals platelet activation (E - scale indicates 2 μm). Whole blood samples (prepared from whole blood smears without thrombin) indicated biconcave morphology of control erythrocytes (F - scale indicates 1 μm) which resembled the morphology seen in ESE-16-treated erythrocytes (G - scale indicates 1 μm) but not that of DMSO-treated erythrocytes at a concentration of 1% as positive control showing signs of oxidative stress with membrane lengthening (H - scale indicates 1 μm).

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Cancer Cell International

ISSN: 1475-2867

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