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Figure 3 | Cancer Cell International

Figure 3

From: Expression of Derlin-1 and its effect on expression of autophagy marker genes under endoplasmic reticulum stress in lung cancer cells

Figure 3

Detection of Derlin-1 and autophagy marker gene expression after transfection of Derlin-1 siRNA with or without TM in A549 cells using western blot. A) Detection of autophagy marker gene expression after transfection of Derlin-1 siRNA with or without TM in A549 cells. B) Detection of Derlin-1 expression after TM exposure in A549 cells. The results show no significant alteration in Beclin 1 and LC3II expression after Derlin-1 siRNA transfection, but the accumulation of p62 indicates a disruption in p62 degradation and impairment of autophagy flux.

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Cancer Cell International

ISSN: 1475-2867

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