Figure 3
From: New strategy to control cell migration and metastasis regulated by CCN2/CTGF
Impact of CCN2/CTGF research in cancer metastasis. (A) Evaluation number of articles published per year that studied the role of CCN2/CTGF on cell migration and metastasis (B) Cell migration and adhesion modulated by CCN2/CTGF. CCN2/CTGF promotes cells migration and adhesion by binding to HSPGs and Integrins in cell surface. Integrins activation potentiates the phosphorylation of the ERK and P38, leading to activation of F-actin and Paxillin resulting in actin reorganization[42]. The same pathway can stimulate FAK, PI-3 kinase ensuing phosphorylation of the PKB/AKT and translocations of P27 to the nucleus that promotes the transcriptional control of RhoA, and thus enhances focal adhesion formation and cellular migration[32].