In vivo anti-proliferative activity of Nova. (A) HepG2 tumor volume in each group; (B, left) The relative proliferation rates (R.P.R.) of Nova, IFN-α2b and fluorouraci. (B, right) The tumor growth inhibition rates (T.I.R.) of Nova, IFN-α2b and fluorouracil. (C) The cell cycle through propidium iodide (PI) staining, specific S phase cell cycle inhibition was observed in Nova and IFN-α2b groups.