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Figure 8 | Cancer Cell International

Figure 8

From: A phosphorylation defective retinoic acid receptor mutant mimics the effects of retinoic acid on EGFR mediated AP-1 expression and cancer cell proliferation

Figure 8

The phosphorylation defective RARα mutant inhibits EGFR expression, ERK1 activation, and AP-1 protein levels. (A) Cultures of G418 resistant (neo) and S77A RARα mutant (RAR1-4) SCC25 clones were harvested for western blot as described in Methods. Blots were incubated with anti-human primary antibodies to AP-1 proteins Fra-1, c-jun, or JunB. These experiments were performed three times using different lysates with similar results. Representative blots are shown.

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