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Table 5 Results of peripheral erythrocyte (RBC) assay for chromosomal breakage or loss. Frequency of micronuclei (MN) per 2000 erythrocytes counted in blood smear from each mouse (mean ± SE, n = number of mice).

From: High dietary level of synthetic vitamin E on lipid peroxidation, membrane fatty acid composition and cytotoxicity in breast cancer xenograft and in mouse host tissue

Vitamin E supplementa ± DOXb n MN/2000 RBCsC
- - 5 7.6 ± 1.4d
- + 6 15.5 ± 2.5e
+ - 5 5.6 ± 1.1d
+ + 8 19.3 ± 1.9e
  1. aAdded (+) synthetic vitamin E at 2000 IU/kg dry AIN·76 food bDOX = doxorubicin treatment: 5 mg/kg body weight i.v. in a lateral tail vein starting two weeks after start of dietary modification and given at 0, 4, 8, 12, 19, 26 and 33 days. Blood smears were made and stained with acridine orange one day after the last injection of DOX. cResults of 2-way ANOVA, significant main effect due to DOX. Results of SNK multiple comparison test, means in column which do not share a superscript letter are significantly different, p < 0.05