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Table 4 Steps involved in Rel/NF-κB activation [42].

From: Rel/Nuclear factor-kappa B apoptosis pathways in human cervical cancer cells

Steps involved in Rel/NF-κB activation
1. Exposure to a stimulus that activates NF-κB such as UV light.
2. Degradation of IκB or its inactivation by phosphorylation by means of protein kinases (McKenzie et al., 2000).
3. Dissociation of the complex between NF-κB family members and IκB inhibitor system.
4. Translocation of NF-κB proteins to the nucleus.
5. DNA binding of NF-κB proteins.
6. Transcriptional induction by NF-κB proteins.