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Table 2 Influence of RARα transformation on the intrinsic and induced expression of MDR1 gene

From: Influence of RAR α gene on MDR1 expression and P-glycoprotein function in human leukemic cells

  MDR1 expression Rh123 efflux (mean fluorescence intensity)
Cells intrinsic ATRA induced intrinsic ATRA induced
H9 - + 450 457
H9/RAR + ++ 506 416
K562 + ++ 446 370
K562/RAR + ++ 403 333
KG-1 ++ +++ 65,7 38,3
KG-1/RAR ++ +++ 90,7 20,2
NB4 - ++ n.d. n.d.
NB4/RAR - ++ n.d. n.d.