Table 2 Influence of RARα transformation on the intrinsic and induced expression of MDR1 gene
From: Influence of RAR α gene on MDR1 expression and P-glycoprotein function in human leukemic cells
MDR1 expression | Rh123 efflux (mean fluorescence intensity) | |||
|---|---|---|---|---|
Cells | intrinsic | ATRA induced | intrinsic | ATRA induced |
H9 | - | + | 450 | 457 |
H9/RAR | + | ++ | 506 | 416 |
K562 | + | ++ | 446 | 370 |
K562/RAR | + | ++ | 403 | 333 |
KG-1 | ++ | +++ | 65,7 | 38,3 |
KG-1/RAR | ++ | +++ | 90,7 | 20,2 |
NB4 | - | ++ | n.d. | n.d. |
NB4/RAR | - | ++ | n.d. | n.d. |