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Table 1 Indices of cytotoxicity (IC50) to several cancer drugs founded in multicellular spheroids and monolayer.

From: Changes in P-glycoprotein activity are mediated by the growth of a tumour cell line as multicellular spheroids

Drug Monolayers IC50 (μM) Multicell. spheroids IC50 (μM)
  INER-51 PCS-1 RR INER-51 PCS-1 RR
Doxorubicin 6.2 9.2 1.4 15 9.8 0.6
Etoposide 2.2 4.1 1.8 >50 >50 ----
Methotrexate 0.8 2.8 3.5 >50 >50 ----
  1. Drug exposition was continuous for 72 hours and drug cytotoxicity was performed by MTT assay. IC50: Fifty percent of the decrease in the survival rate. RR: The value of relative resistance of INER-51 cells vs PSC-1 cells as monolayers or multicellular spheroids.