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Table 1 Indices of cytotoxicity (IC50) to several cancer drugs founded in multicellular spheroids and monolayer.

From: Changes in P-glycoprotein activity are mediated by the growth of a tumour cell line as multicellular spheroids

Drug

Monolayers IC50 (μM)

Multicell. spheroids IC50 (μM)

 

INER-51

PCS-1

RR

INER-51

PCS-1

RR

Doxorubicin

6.2

9.2

1.4

15

9.8

0.6

Etoposide

2.2

4.1

1.8

>50

>50

----

Methotrexate

0.8

2.8

3.5

>50

>50

----

  1. Drug exposition was continuous for 72 hours and drug cytotoxicity was performed by MTT assay. IC50: Fifty percent of the decrease in the survival rate. RR: The value of relative resistance of INER-51 cells vs PSC-1 cells as monolayers or multicellular spheroids.
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Cancer Cell International

ISSN: 1475-2867

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