The figure represents a comparison of different tumor pre-malignant and malignant features in coregistered sodium IR images (panels in first row with phantom P) and their counterpart histology in low power (second row). Notice the heterogeneous regions of tumor and corresponding distinct histopathology. At some selected locations, relative IR sodium MR signal intensities* (A.U.) with reference to sodium phantom P (50 A.U. in top panels) are shown as numbers and histograms (see Figure 8) as distinct values for different tumor stages with different tumor features by NIH Image J 1.63. Panels (1–22) show high power optical microscopy (images 1–8) in control 0 hour (on left) and post-Taxotere 24 hours treated tumors (images 9–22 on right) with distinct features shown by arrows.