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Archived Comments for: Mutations in the mitochondrial DNA D-loop region are frequent in cervical cancer

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  1. Mitochondrial Bed-Side Evaluation: a new Way in the War against Cancer.

    Sergio Stagnaro, Biophysical Semeiotics Research Laboratory.

    21 December 2005

    I agree with the autors’s conclusions of this interesting paper (Himani Sharma, Archna Singh, et al. Mutations in the mitochondrial DNA D-loop region are frequent in cervical cancer Cancer Cell International 2005, 5:34 doi:10.1186/1475-2867-5-34). In fact, in previous articles, I referred that, as a working hypothesis, I thought a long time ago that all chromosomal alterations, of whatever nature, both n-DNA and m-DNA, are necessarily accompanied with similar microvascular modification of the local microcirculatory bed, both structural and functional in nature, in subjects involved by abnormalities of pschyco-neuro-endocrinological-immune system, i.e., in malignancy biological control system, I defined as Oncological Terrain (1-6). Really, both genetical and environmental factors induce contemporaneously parenchymal and microvascular cells alterations, according to the well-known concept of Tiscendorf’s Angiobiotopie, I completed with Angiobiopathy new concept (1). In a few words, all oncological cell-dependent events (control, regulation, duplication, a.s.o.), may happen only by means of singular changes in local structural and functional microcirculation, which notoriously supplies information-material-energy to related tissue cells (See my web sites and Now-a-days, thanks to Biophysical Semeiotics, we can fortunately evaluate clinically microcirculatory bed structure and function in a precise manner, e.g., of breast cancer real risk, and cancer, of course, of all other biological systems, including lymphnodes and bone-marrow, assessing clinically local vasomotility and vasomotion (1-6). Evaluating properly the type of microcirculatory activation of cancer as well as of local lymphnodes and bone-marrow (type I, associated, physiological; type II, intermediate, partially dissociated, characteristic of real oncological risk, and finally type III, dissociated, indicating cancer onset) we can evaluate in a quantitative way the alterations of physiological relation between vasomotility (= chaotic deterministic oscillations of small arterioles and arterioles, according to Hammersen, on the one hand, and vasomotion (= chaotic deterministic oscillations of related capillary and post-capillary primary venules), since the intensity of such as dissociation is correlated with the seriousness of underlying oncological disorders.

    1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologic. Travel Factory SRL., Roma, 2004.

    2) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ediz. Travel Factory, Roma, 2004.

    3) Stagnaro-Neri M., Moscatelli G. Stagnaro S., Biophysical Semeiotics: deterministic Chaos and biological Systems. Gazz. Med. It. Arch. Sc. Med. 155, 125 ,1996

    4) Stagnaro Sergio. "Genes, Oncological Terrain, and Breast Cancer" World Journal of Surgical Oncology., 2005,

    5) Stagnaro Sergio. Relevance of Mitochondria in Cancerogenesis. Journal of Carcinogenesis. 2005, 4:1 doi:10.1186/1477-3163-4-1

    6) Stagnaro Sergio. Bed-Side Evaluating Breast Cancer Real Risk. World Journal of Surgical Oncology. 2005, 3:67 doi:10.1186/1477-7819-3-67. 2005

    Competing interests

    Not declared