Mitochondrial Bed-Side Evaluation: a new Way in the War against Cancer.
Sergio Stagnaro, Biophysical Semeiotics Research Laboratory.
21 December 2005
I agree with the autors’s conclusions of this interesting paper (Himani Sharma, Archna Singh, et al. Mutations in the mitochondrial DNA D-loop region are frequent in cervical cancer Cancer Cell International 2005, 5:34 doi:10.1186/1475-2867-5-34). In fact, in previous articles, I referred that, as a working hypothesis, I thought a long time ago that all chromosomal alterations, of whatever nature, both n-DNA and m-DNA, are necessarily accompanied with similar microvascular modification of the local microcirculatory bed, both structural and functional in nature, in subjects involved by abnormalities of pschyco-neuro-endocrinological-immune system, i.e., in malignancy biological control system, I defined as Oncological Terrain (1-6). Really, both genetical and environmental factors induce contemporaneously parenchymal and microvascular cells alterations, according to the well-known concept of Tiscendorf’s Angiobiotopie, I completed with Angiobiopathy new concept (1). In a few words, all oncological cell-dependent events (control, regulation, duplication, a.s.o.), may happen only by means of singular changes in local structural and functional microcirculation, which notoriously supplies information-material-energy to related tissue cells (See my web sites http://www.semeioticabiofisica.it and http://www.semeioticabiofisica.it/microangiologia.it). Now-a-days, thanks to Biophysical Semeiotics, we can fortunately evaluate clinically microcirculatory bed structure and function in a precise manner, e.g., of breast cancer real risk, and cancer, of course, of all other biological systems, including lymphnodes and bone-marrow, assessing clinically local vasomotility and vasomotion (1-6). Evaluating properly the type of microcirculatory activation of cancer as well as of local lymphnodes and bone-marrow (type I, associated, physiological; type II, intermediate, partially dissociated, characteristic of real oncological risk, and finally type III, dissociated, indicating cancer onset) we can evaluate in a quantitative way the alterations of physiological relation between vasomotility (= chaotic deterministic oscillations of small arterioles and arterioles, according to Hammersen, on the one hand, and vasomotion (= chaotic deterministic oscillations of related capillary and post-capillary primary venules), since the intensity of such as dissociation is correlated with the seriousness of underlying oncological disorders.
1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologic. Travel Factory SRL., Roma, 2004.
2) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ediz. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
3) Stagnaro-Neri M., Moscatelli G. Stagnaro S., Biophysical Semeiotics: deterministic Chaos and biological Systems. Gazz. Med. It. Arch. Sc. Med. 155, 125 ,1996
4) Stagnaro Sergio. "Genes, Oncological Terrain, and Breast Cancer" World Journal of Surgical Oncology., 2005, http://www.wjso.com/content/3/1/45/comments#205475
5) Stagnaro Sergio. Relevance of Mitochondria in Cancerogenesis. Journal of Carcinogenesis. 2005, 4:1 doi:10.1186/1477-3163-4-1http://www.carcinogenesis.com/content/4/1/1/comments#136454
6) Stagnaro Sergio. Bed-Side Evaluating Breast Cancer Real Risk. World Journal of Surgical Oncology. 2005, 3:67 doi:10.1186/1477-7819-3-67. 2005
Mitochondrial Bed-Side Evaluation: a new Way in the War against Cancer.
21 December 2005
I agree with the autors’s conclusions of this interesting paper (Himani Sharma, Archna Singh, et al. Mutations in the mitochondrial DNA D-loop region are frequent in cervical cancer Cancer Cell International 2005, 5:34 doi:10.1186/1475-2867-5-34). In fact, in previous articles, I referred that, as a working hypothesis, I thought a long time ago that all chromosomal alterations, of whatever nature, both n-DNA and m-DNA, are necessarily accompanied with similar microvascular modification of the local microcirculatory bed, both structural and functional in nature, in subjects involved by abnormalities of pschyco-neuro-endocrinological-immune system, i.e., in malignancy biological control system, I defined as Oncological Terrain (1-6). Really, both genetical and environmental factors induce contemporaneously parenchymal and microvascular cells alterations, according to the well-known concept of Tiscendorf’s Angiobiotopie, I completed with Angiobiopathy new concept (1). In a few words, all oncological cell-dependent events (control, regulation, duplication, a.s.o.), may happen only by means of singular changes in local structural and functional microcirculation, which notoriously supplies information-material-energy to related tissue cells (See my web sites http://www.semeioticabiofisica.it and http://www.semeioticabiofisica.it/microangiologia.it). Now-a-days, thanks to Biophysical Semeiotics, we can fortunately evaluate clinically microcirculatory bed structure and function in a precise manner, e.g., of breast cancer real risk, and cancer, of course, of all other biological systems, including lymphnodes and bone-marrow, assessing clinically local vasomotility and vasomotion (1-6). Evaluating properly the type of microcirculatory activation of cancer as well as of local lymphnodes and bone-marrow (type I, associated, physiological; type II, intermediate, partially dissociated, characteristic of real oncological risk, and finally type III, dissociated, indicating cancer onset) we can evaluate in a quantitative way the alterations of physiological relation between vasomotility (= chaotic deterministic oscillations of small arterioles and arterioles, according to Hammersen, on the one hand, and vasomotion (= chaotic deterministic oscillations of related capillary and post-capillary primary venules), since the intensity of such as dissociation is correlated with the seriousness of underlying oncological disorders.
1) Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologic. Travel Factory SRL., Roma, 2004.
http://www.travelfactory.it/semeiotica_biofisica.htm
2) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ediz. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
3) Stagnaro-Neri M., Moscatelli G. Stagnaro S., Biophysical Semeiotics: deterministic Chaos and biological Systems. Gazz. Med. It. Arch. Sc. Med. 155, 125 ,1996
4) Stagnaro Sergio. "Genes, Oncological Terrain, and Breast Cancer" World Journal of Surgical Oncology., 2005, http://www.wjso.com/content/3/1/45/comments#205475
5) Stagnaro Sergio. Relevance of Mitochondria in Cancerogenesis. Journal of Carcinogenesis. 2005, 4:1 doi:10.1186/1477-3163-4-1http://www.carcinogenesis.com/content/4/1/1/comments#136454
6) Stagnaro Sergio. Bed-Side Evaluating Breast Cancer Real Risk. World Journal of Surgical Oncology. 2005, 3:67 doi:10.1186/1477-7819-3-67. 2005
Competing interests
Not declared