Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis

Table 1 uPAR overexpression enhances directional migration and in vitro invasion of PC-3M cells.

		migration	invasion
uPAR transfected cells	upper insert	15.0 ± 3.0%	20.0 ± 2.0%
uPAR transfected cells	lower insert	29.4 ± 4.9%	55.0 ± 12.0%
β-gal plasmid transfected (control) cells	upper insert	18.4 ± 3.2%	14.5 ± 2.8%
β-gal plasmid transfected (control) cells	lower insert	16.1 ± 1.9%	12.0 ± 1.5%

Table data indicate the percent uPAR+ or β-galactosidase+ cells in the population of cells on the upper membrane (general cell population) and lower membrane (cells which successfully traversed the membrane barrier) after a two day period. Data shows the mean and S.E.M of 3 replicate experiments.

ISSN: 1475-2867