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Table 8 Mutations of G to other bases in fifteen hypermutable bases of p53

From: Mechanisms of genotoxin-induced transcription and hypermutation in p53

  A C T
Total G mutations including lung (1857) 1214 107 536
Percent of total 65.3% 5.8% 28.9%
Lung G mutations (273) 66 34 173
Percent of lung 24.2% 12.4% 63.4%
Difference in total G mutations due to the presence of lung G mutations -41.1% +6.6% +34.5%
  1. These hypermutable bases consist of the first two positions of codons 213, 220, 245, 248, 273, and 282 and all positions in codon 249.
  2. The composition of the bases analyzed is 2 As, 4 Cs, 8Gs, and 1T. Table 8 shows the ultimate fate of G mutations in all cancers due to lung mutations (with G-to-A and G-to-T in bold).