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Table 3 A and B: Quantification of VOCs consumed by CALU-1 cancer cells after adsorption on solid sorbents with subsequent TD-GC-MS analyses.

From: Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-1 in vitro

A               
     Concentration [ppbv] after 4 hours of incubation mean ppb Medium mean ppb Cells ppb Cells/ppb Medium
Compound CAS R2 LOD [ppbv] Medium Cells    
methacrolein 78-85-3 0,999 0,466 5,66 9,38 3,93 0,63 0,34 0,84 0,34 0,34 4,898 0,469 0,10
2-methylpropanal 78-84-2 0,998 0,143 19,80 12,98 39,53 9,12 1,21 below LOD 3,35 2,03 20,357 1,649 0,08
methyl tert-butyl ether 1634-04-4 0,999 0,293 1,68 3,43 3,56 1,60 0,67 0,94 1,30 1,11 2,567 1,004 0,39
3-methylbutanal 590-86-3 0,994 0,234 142,29 184,19 218,74 73,14 0,08 2,44 3,02 2,13 154,588 1,916 0,01
n-butyl acetate 123-86-4 0,999 0,134 60,47 105,13 66,58 58,08 2,01 14,70 11,27 13,08 72,566 10,267 0,14
B               
Compound CAS R 2 LOD [ppb v ] Concentration [ppb v ] after 18 hours of incubation mean ppb Medium mean ppb Cells ppb Cells/ppb Medium
      Medium Cells     
acetaldehyde 75-07-0 0,993 1,517 257,527 335,818 315,063   below LOD 116,472 81,692   302,803 66,054 0,22
acetonitrile 75-05-8 0,998 0,147 11,344 7,540 5,764   4,183 3,633 4,100   8,216 3,972 0,48
acrolein 107-02-8 0,998 0,718 5,703 3,462 4,079   2,185 2,071 3,238   4,415 2,498 0,57
methacrolein 78-85-3 0,999 0,466 5,933 4,975 4,723   0,811 0,344 0,702   5,210 0,619 0,12
2-methylpropanal 78-84-2 0,998 0,143 30,915 11,773 21,277   0,532 3,573 0,083   21,322 1,396 0,07
2-butanone 78-93-3 0,999 0,149 3,523 5,206 3,084   1,114 2,812 1,669   3,938 1,865 0,47
methyl tert-butyl ether 1634-04-4 0,999 0,293 2,126 4,202 2,089   0,753 1,654 1,023   2,806 1,143 0,41
3-methylbutanal 590-86-3 0,994 0,234 157,462 206,895 78,027   2,226 2,215 1,529   147,461 1,990 0,01
ethyl tert-butyl ether 637-92-3 0,999 0,215 6,168 11,281 5,121   2,060 4,805 2,229   7,523 3,032 0,40
2-methyl-2-butenal 1115-11-3 0,985 0,430 1,839 1,024 1,163   below LOD below LOD below LOD   1,342 0,000 0,00
hexanal 66-25-1 0,981 0,540 2,043 2,805 1,980   0,791 1,016 0,711   2,276 0,839 0,37
n-butyl acetate 123-86-4 0,999 0,134 43,949 31,381 26,348   11,084 3,032 3,324   33,892 5,813 0,17
  1. The concentration of these VOCs is decreased in headspace of CALU-1 cells in comparison with medium only. Two different incubation times were studied: 4 h (A) and 18 h (B). The concentrations of discussed VOCs are given for measured sample (headspace of CALU-1 cells and of medium). The correlation coefficients (for calibration experiments) and the limits of detection (LODs) are presented.