Figure 2

Mutation frequency in NSCLC. Frequency of activating point mutations and copy number amplifications found in NSCLC in genes specifying components of the classical mitogen activated protein kinase (MAPK) signaling cascade. The majority of alterations are point mutations that convert the proto-oncogene into a constitutive active oncogenic form. Frequencies for mutation-activated β-catenin (CTNNB1) and silencing of the promoter region of CDH1 encoding E-Cadherin are shown. Data are derived from literature and the COSMIC database (version 35).