Figure 2
Interaction of cytostatics with decytabine and zebularine. Concentrations (μM) of particular drugs are indicated on x and y axis. The isobolograms were constructed by connecting the IC50 values of demethylating agents (on the ordinate) with the IC50 of oxaliplatin or 5-FU plotted on the abscissa. When the doses of two agents in combination are lower, or higher, than additive doses, the synergy or antagonism, respectively, is present.