Table 2 Clinicopathologic characteristics, clinical outcomes in breast cancer patients with different HIF-1α 1772 C > T genotypes
From: SNP 1772 C > T of HIF-1α gene associates with breast cancer risk in a Taiwanese population
Genotype | CC (%) | CT (%) | TT (%) | pvalue |
|---|---|---|---|---|
Case number | 53 (55%) | 21 (22%) | 22 (23%) | |
Age | 0.117a | |||
Mean ± SD (years) | 46.5 ± 9.7 | 43.1 ± 10.3 | 49.4 ± 9.6 | |
Range (years) | 27 ~ 68 | 19 ~ 62 | 31 ~ 73 | |
Laterality | 0.463b | |||
Left | 26 (52%) | 10 (20%) | 14 (28%) | |
Right | 27 (58%) | 11 (24%) | 8 (17%) | |
T-stage | 0.303b | |||
T1 or T2 | 35 (53%) | 13 (20%) | 18 (27%) | |
T3 or T4 | 18 (60%) | 8 (27%) | 4 (13%) | |
N-stage | 0.936b | |||
Node negative | 14 (58%) | 5 (21%) | 5 (21%) | |
Node positive | 39 (54%) | 16 (22%) | 17 (24%) | |
HIF-1α expression | 0.311b | |||
Low | 34 (51%) | 15 (22%) | 18 (27%) | |
High | 19 (66%) | 6 (21%) | 4 (14%) | |
VEGF expression | 0.375b | |||
Low | 18 (62%) | 7 (24%) | 4 (14%) | |
High | 35 (52%) | 14 (21%) | 18 (27%) | |
Microvessel density | 0.211b | |||
Low | 32 (63%) | 8 (16%) | 11 (22%) | |
High | 21 (47%) | 13 (29%) | 11 (24%) |