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Table 2 Drug sensitivity of ETCC001 and sub-lines

From: Characterization of ductal carcinoma in situ cell lines established from breast tumor of a Singapore Chinese patient

   IC50(μM)
Anti-neoplastic Class   ETCC001 ETCC006 ETCC007 ETCC008 ETCC010 ETC011 MCF7
ER antagonist Tamoxifen 6.3 34.2 32.8 32.4 30.0 33.5 26.6
Monoclonal Ab Herceptin >10 >10 >10 >10 >10 >10 Not Done
Anti-microtubular Paclitaxel >100 >100 >100 >100 >100 >100 >100
Anti-metabolite 5-fluorouracil >100 >100 >100 >100 >100 >100 >100
Anti-matabolite Gemcitabine >100 >100 >100 >100 >100 >100 >100
Alkylating Cisplatin >100 >100 >100 >100 >100 >100 >100
Anthracycline Docorubicin 9.3 3.2 >100 77.8 5.0 20.8 12.3
Topo I inhibitor Camptothecin >100 >100 >100 >100 >100 >100 4.5
  1. ER: estrogen receptor; Ab: antibody; Topo: topoisomerase
  2. Cells were treated with common chemotherapeutic agents and viability of the cells was determined by measuring cellular ATP levels after 48 hours. Concentration of drug (in μM) which inhibits 50% cell viability (IC50) is shown. The experiments were carried out in triplicates and repeated on different passages of the cells. The result shown is representative of a single experiment.