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Table 1 Downmodulation of NCR and NKG2D in NK-92 cells co-cultured with Cervical cancer cell (CCC) lines

From: Increase of IFN-γ and TNF-γ production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor

  Hela SiHa C-33A
NKG2D    
Basal 2235 2235 2235
Without HO-1 Inhibitor 1690 1830 2110
SnPP 2145* 2050* 2198
ZnPP 2189* 2012* 2241
NKp30    
Basal 2127 2127 2127
Without HO-1 Inhibitor 888 1609 1658
SnPP* 1848 1949 2087
ZnPP* 1929 1893 1989
NKp44    
Basal 2025 2025 2025
Without HO-1 Inhibitor 1684 1801 2090
SnPP 2110* 2087* 2089
ZnPP 1989* 2046* 2105
NKp46    
Basal 1900 1900 1900
Without HO-1 Inhibitor 1500 1588 1610
SnPP* 1925 2043 1892
ZnPP* 1875 1984 1931
  1. CCC HeLa, SiHa, and C-33A were pre-treated with SnPP or ZnPP HO-1 inhibitors. Afterward, transwell assays were performed between NK-92 cells and HeLa, SiHa, and C-33A. Subsequently, the geometric Mean fluorescence intensity (MIF) of NKG2D, NKp30, NKp44, and NKp46 were determined. The Standard deviation (SD) of MIF in all groups did not exceed 135. *P <0.05 SnPP- or ZnPP-treated CCC vs. HeLa, SiHa, and C-33A without treatment.