Chemotherapy induced microsatellite instability and loss of heterozygosity in chromosomes 2, 5, 10, and 17 in solid tumor patients

Table 3 Correlation of MSI/LOH incidence to the low expression of MMR genes

		Mfd41	Tp53-alu	Mfd15	APC	AFM093xh3
hMLH1	Kappa	−0.111	0.198	−0.167	−0.046	−0.153
	p-value	0.212	0.031	0.041	0.587	0.078
	Significance Level	Ns	**	Ns	Ns	Ns
hMSH2	Kappa	0.761	0.776	0.011	0.479	0.011
	p-value	< 0.0001	< 0.0001	0.899	< 0.0001	0.312
	Significance level	***	***	Ns	***	Ns
P53	Kappa	0.139	0.559	−0.145	0.213	−0.125
	p-value	0.129	< 0.0001	0.093	0.016	0.088
	Significance level	Ns	***	Ns	**	Ns
hMSH6	Kappa	0.023	0.101	−0.115	0.033	−0.178
	p-value	0.503	0.413	0.121	0.311	0.052
	Significance level	Ns	Ns	Ns	Ns	Ns
hPMS2	Kappa	0.142	−0.206	−0.162	0.086	−0.107
	p-value	0.119	0.312	0.241	0.311	0.189
	Significance level	Ns	Ns	Ns	Ns	Ns

ISSN: 1475-2867