Table 2 Prognostic value of miR-196a and/or miR-196b expression for the disease free survival and overall survival in univariate and multivariate analyses by Cox Regression

Univariate

Gender

1.005 (0.101-2.208)

NS

1.298 (0.122-2.891)

NS

Age

1.091 (0.198-2.623)

NS

1.255 (0.226-2.879)

NS

Site of primary tumor

0.698 (0.119-5.5196b)

NS

0.869 (0.126-1.881)

NS

Tumor size

0.379 (0.103-0.743)

NS

0.799 (0.136-1.606)

NS

Depth of tumor invasion

0.462 (0.102 -1.039)

NS

0.729 (0.108 -1.692)

NS

Lymph node metastasis

3.232 (1.566-6.676)

0.01

3.528 (1.6196b-7.869)

0.008

TNM stage

5.069 (1.981-12.620)

<0.001

5.869 (1.996-12.788)

<0.001

Histological grade

3.982 (1.119-8.1196b)

0.006

4.569 (1.126-10.281)

0.001

miR-196a expression

4.962 (1.663-10.612)

<0.001

4.996 (1.682-10.138)

<0.001

miR-196b expression

4.903 (1.616-10.299)

<0.001

4.969 (1.618-10.210)

<0.001

miR-196a/miR-196b

5.287 (1.970-12.396)

<0.001

5.899 (1.981-12.902)

<0.001

Multivariate

Lymph node metastasis

2.162 (1.112-4.862)

0.02

2.681 (1.193-5.628)

0.01

TNM stage

4.619 (1.882-10.206)

0.001

4.689 (1.896-10.886)

0.001

Histological grade

2.682 (1.122-5.616)

0.01

2.892 (1.128-5.918)

0.01

miR-196a expression

4.668 (1.632-10.261)

0.001

4.691 (1.688-10.318)

0.001

miR-196b expression

4.532 (1.569-9.696)

0.001

4.696 (1.618-10.110)

0.001

miR-196a/miR-196b

5.106 (1.920-10.638)

<0.001

5.292 (1.961-10.692)

<0.001