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Table 2 Prognostic value of miR-196a and/or miR-196b expression for the disease free survival and overall survival in univariate and multivariate analyses by Cox Regression

From: Upregulation of microRNA-196a and microRNA-196b cooperatively correlate with aggressive progression and unfavorable prognosis in patients with colorectal cancer

  Disease free survival Overall survival
  Hazard ratio (95% CI) P Hazard ratio (95% CI) P
Univariate     
Gender 1.005 (0.101-2.208) NS 1.298 (0.122-2.891) NS
Age 1.091 (0.198-2.623) NS 1.255 (0.226-2.879) NS
Site of primary tumor 0.698 (0.119-5.5196b) NS 0.869 (0.126-1.881) NS
Tumor size 0.379 (0.103-0.743) NS 0.799 (0.136-1.606) NS
Depth of tumor invasion 0.462 (0.102 -1.039) NS 0.729 (0.108 -1.692) NS
Lymph node metastasis 3.232 (1.566-6.676) 0.01 3.528 (1.6196b-7.869) 0.008
TNM stage 5.069 (1.981-12.620) <0.001 5.869 (1.996-12.788) <0.001
Histological grade 3.982 (1.119-8.1196b) 0.006 4.569 (1.126-10.281) 0.001
miR-196a expression 4.962 (1.663-10.612) <0.001 4.996 (1.682-10.138) <0.001
miR-196b expression 4.903 (1.616-10.299) <0.001 4.969 (1.618-10.210) <0.001
miR-196a/miR-196b 5.287 (1.970-12.396) <0.001 5.899 (1.981-12.902) <0.001
Multivariate     
Lymph node metastasis 2.162 (1.112-4.862) 0.02 2.681 (1.193-5.628) 0.01
TNM stage 4.619 (1.882-10.206) 0.001 4.689 (1.896-10.886) 0.001
Histological grade 2.682 (1.122-5.616) 0.01 2.892 (1.128-5.918) 0.01
miR-196a expression 4.668 (1.632-10.261) 0.001 4.691 (1.688-10.318) 0.001
miR-196b expression 4.532 (1.569-9.696) 0.001 4.696 (1.618-10.110) 0.001
miR-196a/miR-196b 5.106 (1.920-10.638) <0.001 5.292 (1.961-10.692) <0.001