Figure 3
From: Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review
Schematic illustration of mechanisms of action of chemotherapeutic agents used in breast cancer therapy upstream of FOXO3a expression. Chemotherapeutic agents in green boxes increase FOXO3a expression/activity; those in red boxes decrease FOXO3a expression/activity. CAV1 = caveolin 1, CDK1 = cyclin dependent kinase 1, ERK = Extracellular signal-regulated kinases, FAS-L = FAS ligand, FAS = fatty acid synthase, FOXO3a – forkhead box O3a, GFR – growth factor receptor IκKβ – inhibitor kappa kinase beta, JNK - Jun N-terminal kinases, PI3k - phosphatidylinositol 3-kinase, SIRT1 = sirtuin 1.