Figure 7

Alteration of G-CSF receptor expression with ATRA. HT93A cells were treated with 100 nM ATRA with or without 50 ng/mL G-CSF for 7 days. (A and B) G-CSF receptor expression was significantly downregulated by ATRA regardless of the presence or absence of G-CSF. G-CSF alone had no effect on G-CSF receptor expression. (C) The alteration of G-CSF receptor was time-dependent. Experiments were independently repeated three times and results are shown as mean ± SD. *p < 0.05 vs. control; #p < 0.05 vs. ATRA.