Figure 2From: PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation Atorvastatin down-regulates expression of PBK in MDA-MB-231 cells but not MCF7 cells. The cells were treated with atorvastatin (AT) or atorvastatin plus geranylgeraniol(GGOH) for 48Â hrs. The effects of atorvastatin and GGOH on expression of PBK mRNA (in A and B) or PBK protein level (in C) were detected by RT-PCR and immunoblotting respectively.Back to article page