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Figure 3 | Cancer Cell International

Figure 3

From: PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation

Figure 3

Geranylgeranylation is required for expression of PBK in MDA-MB-231 cells. A, The cells were treated with atorvastatin (AT) or the geranylgeranyltransferase I inhibitor GGTI-298 for 48 hrs. The effects of atorvastatin or GGTI-298 on PBK protein level were detected by immunoblotting. B, MDA-MB-231 or MCF7 cells were treated with DMSO (control) or atorvastatin for 48 hrs. The cells were stained with anti-PBK (green) or DAPI (blue).

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