Interferon gamma polymorphisms and hepatitis B virus-related liver cirrhosis risk in a Chinese population

Table 3 Frequency distributions of INF-γ polymorphisms among cases and controls

Polymorphisms		Frequencyn (%)			CHB vs. Control		HBV-LC vs. Control
Polymorphisms		LC = 126	CHB = 129	Control = 173	P	OR (95% CI)	P	OR (95% CI)
+874(T/A)
Genotypes
	AA	90 (71.4)	84 (65.1)	116 (67.1)		1^Ref		1^Ref
	AT	32 (25.4)	36 (27.9)	47 (27.2)	0.781	1.086 (0.607-1.943)	0.588	0.863 (0.507-1.470)
	TT	4 (3.2)	9 (7.0)	10 (5.8)	0.481	1.458 (0.511-4.159)	0.264	0.505 (0.152-1.675)
Allele
	A	212 (84.1)	204 (79.1)	279 (80.6)		1^Ref		1^Ref
	T	40 (15.9)	54 (20.9)	67 (19.4)	0.480	1.176 (0.750-1.844)	0.250	0.775 (0.505-1.196)
Dominant model AT + TT vs AA					0.617	1.148 (0.668-1.974)	0.389	0.801 (0.483-1.328)
Recessive model TT vs AA + AT					0.505	1.421 (0.506-3.991)	0.291	0.526 (0.160-1.730)
+2109 (A/G)
Genotypes
	AA	79 (62.7)	72 (55.8)	82 (47.4)		1^Ref		1^Ref
	AG	40 (32.7)	43 (33.3)	68 (39.3)	0.640	0.874 (0.498-1.534)	0.071	0.630 (0.381-1.041)
	GG	7 (5.6)	14 (10.9)	23 (13.3)	0.256	0.625 (0.278-1.407)	0.014	0.321 (0.130-0.793)
Allele
	A	198 (78.6)	187 (72.5)	232 (67.6)		1^Ref		1^Ref
	G	54 (21.4)	71 (27.5)	111 (32.4)	0.232	0.785 (0.528-1.167)	0.003	0.565 (0.388-0.825)
Dominant model AG + GG vs AA					0.392	0.799 (0.478-1.336)	0.013	0.551 (0.344-0.883)
Recessive model GG vs AA + AG					0.295	0.659 (0.301-1.440)	0.034	0.385 (0.159-0.930)

LC, liver cirrhosis; CHB, chronic hepatitis; Ref, reference; OR, odds ratio; 95% CI, 95% confidence interval.
P value: after logistic regressive analysis by adjusting for confounding factors (age, gender, alcohol consumption, etc.).

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