Table 3 Genes down-regulated in the pediatric Wilms tumor compared with normal tissues adjacent to cancerous tissue

1

CDKN2B

Cyclin-dependent kinase inhibitor 2B (p15)

23.45552

0.002128

−11022.3

<0.001

2

FOXC1

Forkhead box C1

3595.198

1.408063

−2553.29

0.0011

3

HOXA4

Homeobox A4

258.1124

1.562344

−165.208

0.0011

4

CDH1

Cadherin 1, type 1, E-cadherin

8.779151

0.157531

−55.7295

0.0012

5

WT1

Wilms’ tumor 1

3.66003

0.099698

−36.7111

0.0013

6

ID4

Inhibitor of DNA binding 4

1390.951

41.75022

−33.316

0.0014

7

HOXA3

Homeobox A3

15.69089

0.814345

−19.2681

0.0017

8

JUN

Jun proto-oncogene

983.5506

107.912

−9.11437

0.0017

9

CASP8

Caspase 8

65.42887

7.329485

−8.9268

0.0021

10

CDKN1A

cyclin-dependent kinase inhibitor 1A (p21)

93.174

15.17592

−6.1396

0.0021

11

ID1

Inhibitor of DNA binding 1

137.3636

25.70027

−5.34483

0.0034

12

DKK3

Dickkopf 3 homolog

8.292778

1.686125

−4.91825

0.0043

13

TP73

Tumor protein p73

7.868963

1.807144

−4.35436

0.0056

14

MEIS2

Meis homeobox 2

177.5222

48.96611

−3.62541

0.0061

15

PCNA

Proliferating cell nuclear antigen

3195.565

1040.969

−3.0698

0.0067

16

TIMP1

TIMP metallopeptidase inhibitor 1

815.6778

394.4536

−2.06787

0.0078