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Fig. 3 | Cancer Cell International

Fig. 3

From: MicroRNA-24 inhibits growth, induces apoptosis, and reverses radioresistance in laryngeal squamous cell carcinoma by targeting X-linked inhibitor of apoptosis protein

Fig. 3

Effect of miR-24 expression on radiosensitivity of LSCC cells. a Radiosensitization by expression of miR-24 was evaluated based on clonogenic cell survival assays. Stably transfected Hep-2 and AMC-HN-8 cells were exposed to various doses of radiation prior to plating. b Colony formation assay was performed as described in Methods. c Flow cytometric detection of apoptosis in stably transfected Hep-2 and AMC-HN-8 cells with or without irradiation (6.0Gy). d Western blot detection of c-caspase-3, total caspase-3, cleaved c-PARP, and total PARP proteins in the stably transfected Hep-2 and AMC-HN-8 cells with or without irradiation (6.0Gy). GAPDH was used as an internal control. Each experiment was performed at least in triplicate. *P < 0.05, **P < 0.01 vs control

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Cancer Cell International

ISSN: 1475-2867

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